Protein Alignment DAAM and fmnl3

DIOPT Version :10

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: XP_004911895.1
• Gene: fmnl3 / 100493601
• XenbaseID: XB-GENE-6086974
• Length: 1023
• Species: Xenopus tropicalis
• Alignment Length: 1174
• Identity: 298/1174 - (25%)
• Similarity: 487/1174 - (41%)
• Gaps: 338/1174 - (28%)

  Fly   349 PMPSVDELDTKFAELVEELDLTAPNKEAML-SLPAQKKWQIYCSRKLPLDAADGPDAAAVTQPPT 412
            |||...||:.:||.::..::| .|:|..:| ....:|||.:.|.:          :...|..||
 Frog    21 PMPEPGELEERFAMVLSSMNL-PPDKARLLRQYDNEKKWDLICDQ----------ERFQVKNPP- 73

  Fly   413 AEHYIERLKELVVHISLSPEDSPSHELGNRLDGHAAFVDALKTALRTSTHSFVLRFVELD--GLP 475
             ..||::|:..     |.| .....:...|:......:..|:.:|||:...:|..|:..|  ||.
 Frog    74 -HTYIQKLQSF-----LDP-GVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNNDNKGLD 131

  Fly   476 ALLDLLLQL------------------------------DIRVANS---PLHTSL---------- 497
            .|::.|...                              |::..||   |....|
 Frog   132 VLVEYLSFAQCAVMFDFEGLENGEDGLVEKSKPWSRSIEDLQHPNSLPTPFANGLARSARQSVLR 196

  Fly   498 --------------------------IGCIKALMNNSMGRAHVLAHPTAIDTIARSLAADNIRTK 536
                                      |.|::|:||...|...|::||.|::.||.||...|.|||
 Frog   197 SYNTLPGKKALKNSRLVSQKDDVHVCIMCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTK 261

  Fly   537 IAALEILGAVCLVPGGHRKVLQAMLHFQVFATERTRFQSIVNDLDRSTYAYRD---NVNLKTALM 598
            ...||:|.|||||.|||..:|.|..:|:....|..||:.::.       .:|:   |::...|.|
 Frog   262 ALVLELLAAVCLVRGGHEIILSAFDNFKEVCKETHRFEKLME-------YFRNEDSNIDFMVACM 319

  Fly   599 SFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDKLRTHENETL----DRHLDFFEMVRAEDE 659
            .|:|.|::   ..|::.||:||::||..||::..::|.:..|:|.|    ..:||
 Frog   320 QFINIVVH---SVEDMNFRVHLQFEFTKLGLEDFLEKAKHTESEKLLVQIQAYLD---------- 371

  Fly   660 KEFARRFKEEHVDTKSAGSMFELLRRKLSHSPAYPHMLSLLQHMLLLPYTGHCTEHWLLIDRVVQ 724
                              ::|::                                ..||.|...:
 Frog   372 ------------------NVFDV--------------------------------GGLLEDAETK 386

  Fly   725 QIVLQ-VEQRPNSDLIVDPDDPEKQLKLAAESPVHDPDVAPLQIDVAKLVRLLVKEEQLTQARKR 788
            .:.|: ||:                                             .||||:...::
 Frog   387 NVALEKVEE---------------------------------------------LEEQLSHMTEK 406

  Fly   789 ADELERENF----DVQSRLAKKEQELDLRMQEKEDLETGLARMRERL-EKESA-QHSQAVQRAQT 847
            ..:||.||.    :::..|..:|:||.:..:..|:....:..:|..: |||.| ||.:.:::|.|
 Frog   407 LLDLENENIMRVAELEKTLLHREKELTVLKETYENANHQVHTLRRIIKEKEEAFQHLRQLEQANT 471

  Fly   848 AEMRAEDLQHRLISEQQERARLERLVTEGSIPDDQKVAGLTGCNGAVSPPPAPPMLKAIPPPPPP 912
            ::.....|.                ::..||.|....|.|.       ||||...:.|.||||||
 Frog   472 SQPAGSTLP----------------LSATSIGDISLSAELL-------PPPASASVPAPPPPPPP 513

  Fly   913 MAPSMMPPPPPPCPGAPPPPPSMAQTMAPAPPKVDLPKKNVPQPT-------------NPLKS-- 962
                  ||||||.|  |||||.|.....|.||   ||..:   |:             .|:|:
 Frog   514 ------PPPPPPPP--PPPPPPMPSKCPPPPP---LPSSS---PSVILTTGLSAIRIKKPIKTKF 564

  Fly   963 ----FNWSKLPDAKLQGTVWSELDESKLYNNMELESIDKLFSAYQKNGVSATDGSYEDL----RV 1019
                |||:.|...::.|||:::||:.::..:::::..::||.       :...|...||    ..
 Frog   565 RLPVFNWTALKPNQISGTVFNDLDDERILQDLDMDKFEELFK-------TKAQGPAIDLTCPKNK 622

  Fly  1020 TGKAAKQKVLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDSNEQLQLDMVEQLLKFTPSAEE 1084
            |.:.:..|| ::::..||:|..|.|.|...|..||.|||.:.|. ..|.:|.||.|::|.|:..|
 Frog   623 TSQRSASKV-TLLEANRAKNLAITLRKAGRSSEEICKAIQTFDL-RTLPVDFVECLVRFLPTEAE 685

  Fly  1085 RALLDEHSED---IESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEASR 1146
            ..||.::..:   :|.|:..|||:...||:....||:..:.:...|...:..|.|::.:|:.||.
 Frog   686 VKLLRQYERERKPLEDLSDEDRFMMLFSKVERLSQRMSIMTFLGNFNENLQLLTPQLNAVIAASV 750

  Fly  1147 EVARSRRLRKLLELVLALGNYMNRGARGNASGFRLASLNRLADTKSSAAKGTTLLHYLVQVIERK 1211
            .|..|.:|:::||::||||||||...||:..||:|.||:.|.||||:..| .|||:|:..:.:.|
 Frog   751 SVKSSPKLKQMLEVILALGNYMNSSKRGSVYGFKLQSLDLLQDTKSTDRK-LTLLNYIALIAKEK 814

  Fly  1212 FKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQQGDRFLPVMREF 1276
            :.::....:::..|.:|:.|||..:..|::.|..|:..:.:|...|.::           .:|.|
 Frog   815 YSEVATFYNELHFVEKAAAVSLENVLLDVKELGKGMDLIRKESHHHDNT-----------FLRNF 868

  Fly  1277 HAQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEARHDNESFRRR 1341
            .:....:..:|:...:..:..:...|..|||:.....|..||.:|..|:.::.||..:|| .|::
 Frog   869 VSSNEGKLDKLQKDARTAEEAYAAVVLYFGENPKTTPPSVFFPVFARFIKSYKEAELENE-MRKK 932

  Fly  1342 QEE--EEKRAKQEAELKKRTIERKNKTGLMTSVARNLGLKSGSSNGDPDSPAKGGDNKGEFDDLI 1404
            |||  .||...|||  ||.                           ||.||.:  .||.:..|||
 Frog   933 QEEVLREKMLAQEA--KKL---------------------------DPKSPVQ--KNKRQQQDLI 966

  Fly  1405 SALR 1408
            :.||
 Frog   967 AELR 970

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:461886	63/270 (23%)
		Drf_FH3	551..737	CDD:461885	38/193 (20%)
		Smc	<765..>875	CDD:440809	23/115 (20%)
		FH2	950..1328	CDD:396655	111/403 (28%)
fmnl3	XP_004911895.1	Drf_GBD	21..273	CDD:461886	63/270 (23%)
		Drf_FH3	276..458	CDD:461885	54/296 (18%)
		FH2	556..921	CDD:396655	110/385 (29%)