Protein Alignment DAAM and fmnl2

DIOPT Version :10

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: XP_012826322.1
• Gene: fmnl2 / 100491499
• XenbaseID: XB-GENE-1004377
• Length: 1106
• Species: Xenopus tropicalis
• Alignment Length: 1240
• Identity: 321/1240 - (25%)
• Similarity: 525/1240 - (42%)
• Gaps: 319/1240 - (25%)

  Fly   349 PMPSVDELDTKFAELVEELDLTAPNKEAML-SLPAQKKWQIYCSRKLPLDAADGPDAAAVTQPPT 412
            |||...||:.:||.::..::| .|:|..:| ....:|||::.|.:          :...|..||
 Frog    24 PMPEPGELEERFAIVLNAMNL-PPDKARLLRQYDNEKKWELICDQ----------ERFQVKNPP- 76

  Fly   413 AEHYIERLKELVVHISLSPEDSPSHELGNRLDGHAAFVDALKTALRTSTHSFVLRFV--ELDGLP 475
             ..||::||..     |.|. .|..:...|:......:..|:.:|||:...:|..|:  |..||.
 Frog    77 -HTYIQKLKGY-----LDPA-VPRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLD 134

  Fly   476 ALLDLL-------------LQLDIR-----------------------------VANSPLHTSL- 497
            .|::.|             |:.::.                             :..|..|::|
 Frog   135 VLVEYLSFAQYAVTFDFECLENNVENSVDKSKPWSRSIEDLHRGSNLPSPVGNSITRSGRHSTLR 199

  Fly   498 -------------------------IGCIKALMNNSMGRAHVLAHPTAIDTIARSLAADNIRTKI 537
                                     |.|::|:||...|...|::|..|::.||.||...|.|||.
 Frog   200 YNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHLHAVNEIALSLNNKNPRTKA 264

  Fly   538 AALEILGAVCLVPGGHRKVLQAMLHFQVFATERTRFQSIVNDLDRSTYAYRDNVNLKTALMSFVN 602
            ..||:|.|||||.|||..:|.|..:|:....|:.||:.::.......    :|::...|.|.|:|
 Frog   265 LVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNED----NNIDFMVACMQFIN 325

  Fly   603 AVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDKLRTHENETLDRHLDFFEMVRAEDEKEFARRFK 667
            .|::   ..|::.||:||::||..|.:...:|||:..|::.|.      ..::|..:..|.....
 Frog   326 IVVH---SVEDMNFRVHLQFEFTKLALDEYLDKLKHTESDKLQ------VQIQAYLDNVFDVGAL 381

  Fly   668 EEHVDTKSAG-SMFELLRRKLSHSPAYPHMLSLLQHMLLLPYTGHCTEHWLLIDRVVQQIVLQVE 731
            .|..:||:|. ...|.|...:||                            |.:::
 Frog   382 LEDAETKNAALERVEELEENISH----------------------------LSEKL--------- 409

  Fly   732 QRPNSDLIVDPDDPEKQLKLAAESPVHDPDVAPLQIDVAKLVRLLVKEEQLTQARKRADELEREN 796
                       .|.|.:.                   :||:|.|   |:||.|..|
 Frog   410 -----------QDTENEA-------------------MAKIVEL---EKQLMQRNK--------- 432

  Fly   797 FDVQSRLAKKEQELDLRMQEKEDLETGLARMRERL-EKESAQHSQAVQRAQTAEMRAEDLQHRLI 860
                        |||:..:..:|..|.:..:|:.: |||     :|:||..|.|.:..:|
 Frog   433 ------------ELDIAREVCKDANTQVHTLRKMVKEKE-----EAIQRQSTLERKIHEL----- 475

  Fly   861 SEQQERARLER----------LVTEGSIPDDQK----------------------VAGLTGC--- 890
             |:|...::::          :|..||:|...:                      |.|:.|.
 Frog   476 -EKQGSIKIQKKGDGDISITPMVASGSVPSGSEGTPGGAPGASISGPSIPCGTTSVPGVAGALSS 539

  Fly   891 -----------------NGAVS----PPPAPPMLKAIPPPPPPMAPSM---MPPPPPPCPGAPPP 931
                             ||.||    |||.||.....||||||..||.   :||||||.|||||.
 Frog   540 TTLVPPSSPLLGSSSVENGPVSAPSPPPPPPPPPPPPPPPPPPPLPSAEPPVPPPPPPPPGAPPL 604

  Fly   932 PPSMAQT------MAPAPPKVDLPKKNVPQPTN-PLKSFNWSKLPDAKLQGTVWSELDESKLYNN 989
            |.|.:.|      :|..|.|:...|...|..|. .:..|||..|...::.|||::|:|:.::..:
 Frog   605 PGSASPTVIFNSGLADGPIKLFSVKIKKPIKTKFRMPVFNWVALKPHQINGTVFNEIDDERILED 669

  Fly   990 MELESIDKLFSAYQKNGVSATDGSYEDLRVTGKAAKQKVLS---VIDGRRAQNCTILLSKLKMSD 1051
            :.::..:::|.       :...|...|:..|.:.|..||.|   :::..||:|..|.|.|...:.
 Frog   670 INVDEFEEIFK-------TKAQGPAIDISSTKQKAAPKVTSKVTLLEANRAKNLAITLRKAGKTA 727

  Fly  1052 MEISKAILSMDSNEQLQLDMVEQLLKFTPSAEERALLDEHSED---IESLARADRFLYEISKIPH 1113
            .||.|||...|. :.|.:|.||.|::|.|:..|..:..::..:   :|:|:..|||:.:.|||..
 Frog   728 EEICKAIQLFDL-KTLPVDFVECLMRFMPTEGEVKVFRQYEREKKPLENLSDEDRFMMQFSKIER 791

  Fly  1114 YEQRLKSLHYKKRFMLTINDLVPRITSVMEASREVARSRRLRKLLELVLALGNYMNRGARGNASG 1178
            ..|::..:.:...|..:|..|.|::.:::.||..:..|::|:|:||::||||||||...||...|
 Frog   792 LMQKMTIMAFIGNFSESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYG 856

  Fly  1179 FRLASLNRLADTKSSAAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQML 1243
            |:|.||:.|.||||:..| .|||||:..|:..|:..:....::|.:|.:|:.|||..:..|::.|
 Frog   857 FKLQSLDLLLDTKSTDRK-QTLLHYISNVVRDKYLQVALFYNEIHYVEKAAAVSLENVLLDVKEL 920

  Fly  1244 RTGLADVAREIEFHRSSGPAQQGDRFLPVMREFHAQASVRFAELEDKFQDMKTRFDRAVRLFGED 1308
            :.|:....||...|..:          .:::||...:.||..:|:|..:..:..||..|:.|||:
 Frog   921 QRGMDLTKREYTMHDHN----------VMLKEFIQNSEVRLKKLQDDAKISQDAFDDVVKYFGEN 975

  Fly  1309 GSVLQPDEFFGIFDSFLAAFAEARHDNESFRRRQEEE--EKRAKQEAELK---KRTIERKNKTGL 1368
            .....|..||.:|..|:.|:..|..:|| .|::||:.  ||..:|||.::   :::...|:|...
 Frog   976 PKTTPPSVFFPVFVRFVKAYKNADEENE-MRKKQEQALMEKLLEQEAMMEQQDQKSPSHKSKRQQ 1039

  Fly  1369 MTSVA--RNLGLKSGSSNGDPDSPAKGGDNKGEFDDLISALRT-----GDVFGEDMAKFKRSRKA 1426
            ...:|  |...:|      |.....:|.|  |..:|:|:.||.     .|.....:.|....:..
 Frog  1040 QELIAELRRRQVK------DNRHVYEGKD--GAIEDIITDLRNQPYIRADAMRRSVRKRFDDQNM 1096

  Fly  1427 RVLNG 1431
            |..||
 Frog  1097 RSANG 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:461886	63/269 (23%)
		Drf_FH3	551..737	CDD:461885	39/186 (21%)
		Smc	<765..>875	CDD:440809	27/120 (23%)
		FH2	950..1328	CDD:396655	117/384 (30%)
fmnl2	XP_012826322.1	Drf_GBD	23..275	CDD:461886	63/269 (23%)
		Drf_FH3	278..475	CDD:461885	64/305 (21%)
		FH2	630..981	CDD:396655	111/369 (30%)