DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAAM and fhdc1

DIOPT Version :9

Sequence 1:	NP_001188522.1	Gene:	DAAM / 31075	FlyBaseID:	FBgn0025641	Length:	1463	Species:	Drosophila melanogaster
Sequence 2:	XP_001920056.2	Gene:	fhdc1 / 100148864	ZFINID:	ZDB-GENE-040826-4	Length:	1165	Species:	Danio rerio

Alignment Length:	510	Identity:	138/510 - (27%)
Similarity:	234/510 - (45%)	Gaps:	69/510 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   897 PPAPPMLKAIPPPPPPMAPSMMPPPPPPCPGAPPPPPSMAQTMAPAPPKVDLPKKNVPQPTNPLK 961
            |||.|     ||||||      |||||..||......|.             .|:.|       :
Zfish    47 PPAVP-----PPPPPP------PPPPPQAPGNSGQHASR-------------KKRRV-------R 80

  Fly   962 SFNWSKLPDAKLQG--TVWSELDESKLYNNMELESIDKLFSAYQKNGVSATDGSYEDLRVTG--K 1022
            ||.|..:|:.|::|  .:|:.....:.| .::::::::||...::.....:.|.....|..|  |
Zfish    81 SFFWKTIPEEKVRGKPNIWTLAVRQQQY-QIDVKTVEELFGQQEEVRTQTSGGHSRTGRSRGSFK 144

  Fly  1023 AAKQKVLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDSNEQLQLDMVEQLLKFTPSAEERAL 1087
            .:|.:: |::|.:|..|..|.|.:.|.|:..|.:.|...:| :|...:.:::|||..|.|:|...
Zfish   145 ESKDEI-SILDSKRGMNIGIFLKQFKKSNHAIVEDIRLFNS-KQYGAEPLKELLKLLPEADEVKR 207

  Fly  1088 LDEHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEASREVARSR 1152
            |.|...|...|...|.|::::.::|.::.|::.:..::.|......:...|..|.:|:.::....
Zfish   208 LREFKGDANKLTLVDSFMFQLIQVPRFDVRIEVMVLQEEFFPLCTAMSRDINIVRQATEDLMNCE 272

  Fly  1153 RLRKLLELVLALGNYMNRGA-RGNASGFRLASLNRLADTKSSAAKGTTLLHYLVQVIERKFKDLL 1216
            .|..:|.|||..||.||.|. .|||.||:|:||..|||||:: ..|..|||::....::|.:.||
Zfish   273 ELHAILHLVLQAGNIMNAGGYAGNAVGFKLSSLLSLADTKAN-KPGMNLLHFVALEAQKKDEALL 336

  Fly  1217 KLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQQGDRFLPVMREFHAQAS 1281
            |..:.:.|::.|:::|:..::.:...|......:.::|         |..|.....:..|...::
Zfish   337 KFPEKLTHIQSAARISVENIEGEFSSLYVKTRSLEQKI---------QDDDELQKQLDPFLQSSA 392

  Fly  1282 VRFAELEDKFQDMKTRFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEARHDNESFRRRQEEEE 1346
            ....:|:.:..|::...:..:..|.||....:.||.|.||..|...|.:|..||..   |:.:||
Zfish   393 KALQDLKHRRLDLRKEGNALIDFFCEDKDTFKLDECFRIFQDFCLKFKKAVKDNSD---RELKEE 454

  Fly  1347 KRAKQEAELKKR-------TIERKNKTGLMTSVARNLGLKSGSSNGDPDSPAKGG 1394
            .|.::..||::|       .||    ||      .|.|....||..|.|...|.|
Zfish   455 ARQRRLRELEERRCAWGAANIE----TG------GNGGFGRSSSENDVDILTKDG 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920
		Drf_FH3	551..737	CDD:283917
		FliJ	779..>875	CDD:280262
		FH2	950..1328	CDD:280362	97/382 (25%)
fhdc1	XP_001920056.2	FH2	74..440	CDD:280362	97/398 (24%)
fhdc1	XP_001920056.2	Herpes_ICP4_C	922..>1134	CDD:332854
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1922
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820