Protein Alignment DAAM and daam1

DIOPT Version :10

• Sequence 1: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Sequence 2: XP_004917271.2
• Gene: daam1 / 100125016
• XenbaseID: XB-GENE-983772
• Length: 1074
• Species: Xenopus tropicalis
• Alignment Length: 1169
• Identity: 545/1169 - (46%)
• Similarity: 769/1169 - (65%)
• Gaps: 140/1169 - (11%)

  Fly   319 VWCGCFKDDEPPEICV---VEGAFTLQTLTPTQPMPSVDELDTKFAELVEELDLTAPNKEAMLSL 380
            ::| ||:..|.|||..   .:..|.||::.|..|:|.|:|||..|.|||:||||:..::|||.:|
 Frog    14 IFC-CFRSSEHPEITYRLRNDSNFALQSMEPALPVPPVEELDAMFVELVDELDLSEKHREAMFAL 77

  Fly   381 PAQKKWQIYCSRKLPLDAADGPDAAAVTQPPTAEHYIERLKELVVHISLSPEDSPSHELGNRLDG 445
            .|:||||||||:|  .|..:|    |.:.|   |.||::|..|....:|...|....:..|:.
 Frog    78 SAEKKWQIYCSKK--KDHEEG----ATSWP---EFYIDQLNSLAARRTLFAMDKEDEDERNKT-- 131

  Fly   446 HAAFVDALKTALRTSTHSFVLRFVELDGLPALLDLLLQLDIRVANSPLHTSLIGCIKALMNNSMG 510
                :::|||||||....||.||::||||..:|:.|..:|..:|.|.:|||||||||||||||.|
 Frog   132 ----IESLKTALRTKPMRFVTRFIDLDGLTCILNFLKCMDYEIAESQIHTSLIGCIKALMNNSQG 192

  Fly   511 RAHVLAHPTAIDTIARSLAADNIRTKIAALEILGAVCLVPGGHRKVLQAMLHFQVFATERTRFQS 575
            |||||||..:|:.||:|||.:||:||:|.|||:||||||||||:|||:||||:|.:|:||||||:
 Frog   193 RAHVLAHSESINVIAQSLATENIKTKVAVLEIMGAVCLVPGGHKKVLEAMLHYQRYASERTRFQT 257

  Fly   576 IVNDLDRSTYAYRDNVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDKLRTHE 640
            ::|||||||..|||.|:||||:|||:||||:.|.|.|:|:|||||||||||||||||:||||.||
 Frog   258 LINDLDRSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVMDKLREHE 322

  Fly   641 NETLDRHLDFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHSPAYPHMLSLLQHMLL 705
            |.|||||||||||:|.|||.|||:||...|:|||||..||||:|::|:|:.:|||..|::.|.|.
 Frog   323 NSTLDRHLDFFEMLRNEDELEFAKRFDLVHIDTKSATQMFELIRKRLTHTESYPHFTSIMHHCLQ 387

  Fly   706 LPY--TGHCTEHWLLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPVHDPDVAPLQ-I 767
            :||  :|:...||||:||:|||||:|.|:.                        .|||::||: .
 Frog   388 MPYKRSGNTVHHWLLLDRIVQQIVIQNEKG------------------------QDPDISPLENF 428

  Fly   768 DVAKLVRLLVKEEQLTQARKRADELERENFDVQSRLAKKEQELDLRMQEKEDLETGLARMRERLE 832
            :|..:||:||.|.::.|.:::|:::.:|:.::|.:|.|||:|.|.:.||||::...|.:|:|:||
 Frog   429 NVKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLE 493

  Fly   833 KESAQHSQAVQRAQTAEMRA--EDLQHRLISEQQERARLERLVTEGSIPDDQKVAGLTGCNGAVS 895
            ||:.::....|  |.||:.|  ::|..|.:|.|              ||         ||
 Frog   494 KETTEYKNVKQ--QVAELTAQIQELNSRAVSAQ--------------IP---------GC----- 528

  Fly   896 PPPAP-----PMLKAIPPPPPPMAPSMM-----PPPPPPCPGAPPPPPS--MAQTMAP-APPKVD 947
            |||.|     ||.....|||||..|.|:     ||||||.||.|||||.  :..|..| ||....
 Frog   529 PPPPPGAPGGPMSGNFMPPPPPPPPPMLCGIAPPPPPPPPPGGPPPPPGPPLLGTAPPGAPMGPA 593

  Fly   948 LPKKNVPQPTNPLKSFNWSKLPDAKLQGTVWSELDESKLYNNMELESIDKLFSAYQK-------N 1005
            :.:||:|||.||||||||.||.|.||:||:|.:||::|::..::||.|::.|||||:       |
 Frog   594 MKRKNIPQPKNPLKSFNWVKLADNKLEGTLWIDLDDAKVFKILDLEDIERTFSAYQRQQDFFMNN 658

  Fly  1006 GVSATDGSYEDLRVTGKAAKQKVLSVIDGRRAQNCTILLSKLKMSDMEISKAILSMDSNEQLQLD 1070
            |:...:....|..::.| .|.|.||||||||||||.||||:||:::.||.:|||:||..|.|..|
 Frog   659 GIKQKETDCTDDTLSSK-MKVKELSVIDGRRAQNCNILLSRLKLTNEEIKRAILTMDEQEDLPKD 722

  Fly  1071 MVEQLLKFTPSAEERALLDEHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLV 1135
            |:||||||.|...:..||:||..:::.:|:|||||:|:|:|.||:|||:||::||:|...:.::.
 Frog   723 MLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVK 787

  Fly  1136 PRITSVMEASREVARSRRLRKLLELVLALGNYMNRGARGNASGFRLASLNRLADTKSSAAKGTTL 1200
            |::.::.:||:||.:|:.|::|||:|||.|||||:|.||||.||:::|||::||||||..|..||
 Frog   788 PKVEAIRDASKEVLQSKCLKQLLEVVLAFGNYMNKGQRGNAYGFKVSSLNKIADTKSSIDKNITL 852

  Fly  1201 LHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQQ 1265
            ||||:.|:|:|:..::.|.:::..:..|:||::.|::|:|..||.||..|..|:|:.::. |...
 Frog   853 LHYLITVVEKKYPKIVNLHEELQAISVAAKVNMTELEKEIGTLRNGLKSVENELEYQKTQ-PTLP 916

  Fly  1266 GDRFLPVMREFHAQASVRFAELEDKFQDMKTRFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAE 1330
            ||:|:.|:.:|...|...|.::||...:.|..|.::.:.|||:.:.:||||||||||.||.||.|
 Frog   917 GDKFVSVVSQFITVAGFSFCDVEDLLSEAKELFMKSAKHFGEETNKMQPDEFFGIFDQFLQAFLE 981

  Fly  1331 ARHDNESFRRRQEEEEKRAKQEAELKKRTIERKNKTGLMTSVARNLGLKSGSSNGDPDSPAKGGD 1395
            |:.:||:.|:|:||||:|.:.||:||::. ||:.|       ||              ...:.|:
 Frog   982 AKQENENIRKRKEEEERRIRMEAQLKEQR-ERERK-------AR--------------KAKENGE 1024

  Fly  1396 NKGEFDDLISALRTGDVFGEDMAKFKRSRKARVLNGGGSSTGHTSPPRHGSLQREESGRERERT 1459
            .:||||||:||||:|:||.:|::|.||:|| |:.:                 |..||.|||..|
 Frog  1025 EEGEFDDLVSALRSGEVFDKDLSKLKRNRK-RIAS-----------------QNTESSRERPVT 1070

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:461886	100/198 (51%)
		Drf_FH3	551..737	CDD:461885	123/187 (66%)
		Smc	<765..>875	CDD:440809	37/112 (33%)
		FH2	950..1328	CDD:396655	182/384 (47%)
daam1	XP_004917271.2	Drf_GBD	45..230	CDD:461886	100/199 (50%)
		Drf_FH3	233..437	CDD:461885	131/227 (58%)
		SMC_prok_B	<435..>524	CDD:274008	33/90 (37%)
		FH2	596..979	CDD:396655	182/384 (47%)