DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11403 and RTEL1

DIOPT Version :9

Sequence 1:	NP_569898.1	Gene:	CG11403 / 31072	FlyBaseID:	FBgn0026876	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_001269938.1	Gene:	RTEL1 / 51750	HGNCID:	15888	Length:	1300	Species:	Homo sapiens

Alignment Length:	899	Identity:	243/899 - (27%)
Similarity:	358/899 - (39%)	Gaps:	220/899 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 FPYSPYEIQEQLMQELFQVLERGQVGIFESPTGTGKSLTLTCGALTWLARHEELVRTEMLARIRG 84
            ||:.||:.|::.|.::.:.|::...||.||||||||:|.|.|..|.|    .|.:|..:.||
Human    13 FPFQPYKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAW----REHLRDGISAR--- 70

  Fly    85 VEQELAKLKEESEQSSNWLESQGKSRAQRAELLRLQHLQALLDKQEQQLDQIRKGAKKHKRQGRV 149
                  |:                  |:||                               ||.:
Human    71 ------KI------------------AERA-------------------------------QGEL 80

  Fly   150 HPGKLEELEKDLDPESDSDSEHETADGPQEAAEDRYRPV-QIFFCSRTHSQLAQIVAELRKTPHG 213
            .|          |....|......|.|...|.   |..: :|.:.|||||||.|::.|||.|.:.
Human    81 FP----------DRALSSWGNAAAAAGDPIAC---YTDIPKIIYASRTHSQLTQVINELRNTSYR 132

  Fly   214 QSVRSISLGSRQQLCGNPAVRKLKHVGLMNERCLDMATKKARPNPSKKSRLTAEANSRCPFKAAS 278
            ..|  ..||||:|||.:|.|:|.:    .|...:.:..||.             |:..|.|....
Human   133 PKV--CVLGSREQLCIHPEVKKQE----SNHLQIHLCRKKV-------------ASRSCHFYNNV 178

  Fly   279 LVESLRDLALTEPLDIEELANEGTACGGCSYYASRSAVEHAQLILLPYQLLLQKSARNQLGISLK 343
            ..:||.....:..||||:|...|:....|.||.||:..:.|.:|.:||..||...:|....|.||
Human   179 EEKSLEQELASPILDIEDLVKSGSKHRVCPYYLSRNLKQQADIIFMPYNYLLDAKSRRAHNIDLK 243

  Fly   344 GSIVIVDEAHNLLDSVAQLHGSEISRQQLERAKVQISGYKDHFQKRFTTKNLLKINQIIFIIRRL 408
            |::||.|||||:.....:....:::...|      .||
Human   244 GTVVIFDEAHNVEKMCEESASFDLTPHDL------ASG--------------------------- 275

  Fly   409 LKILDQRKELQSNGCSMMRTY-ELTAEGDFFNIDLCELLDFCARTRFARKVQGRADRMERE---- 468
            |.::||..|.|:........: |.:|:.....::: ||.|.........:::|..|.:|..
Human   276 LDVIDQVLEEQTKAAQQGEPHPEFSADSPSPGLNM-ELEDIAKLKMILLRLEGAIDAVELPGDDS 339

  Fly   469 --PRP--------SENQAPVSTARSL------ILQRLASEQKLKEKTKSVKRRVEDINKEDKAEE 517
              .:|        :|.|....|...:      |:|.||....:...|..:::..:.|
Human   340 GVTKPGSYIFELFAEAQITFQTKGCILDSLDQIIQHLAGRAGVFTNTAGLQKLADII-------- 396

  Fly   518 LQEQQKPTKKPVEEVAP---SPIRPLLAFLETLTSNAEDGRILVDPVGG---------------- 563
                     :.|..|.|   ||..|  |.|..|.|.    ::.:.|..|
Human   397 ---------QIVFSVDPSEGSPGSP--AGLGALQSY----KVHIHPDAGHRRTAQRSDAWSTTAA 446

  Fly   564 -----TLKYILLDPAEQFADIVAE-ARAIVIAGGTMQPTKE--LKEQL-FTGCHDRLVERFYNHV 619
                 .|.|....|.....::|.: .|::::..||:.|...  |:.|: |..|.:.      .|:
Human   447 RKRGKVLSYWCFSPGHSMHELVRQGVRSLILTSGTLAPVSSFALEMQIPFPVCLEN------PHI 505

  Fly   620 VANDAILPFVISNGPSGAPLSFKFAHRGSAEMLRELSMILRNLCQVVPGGVVCFLPSYEYLDKVY 684
            :....|...|:..||.||.||..|..|.|.|.|..|...|.|:.:|||.|::.|.|||..::|..
Human   506 IDKHQIWVGVVPRGPDGAQLSSAFDRRFSEECLSSLGKALGNIARVVPYGLLIFFPSYPVMEKSL 570

  Fly   685 KYLEQSGTLETISGRKSVFRE--VSGSAEQLLDNYALAIKRPASYGALLLSVVGGKLSEGLNFAD 747
            ::.........:...|.:|.|  ..||..:.:..|...:..|.|.||..|:|..||.||||:|:|
Human   571 EFWRARDLARKMEALKPLFVEPRSKGSFSETISAYYARVAAPGSTGATFLAVCRGKASEGLDFSD 635

  Fly   748 DLGRAVLVVGLPYSNSLSPELRQRMQHLDEKLGPG-------AGNEYYENLCVKAVNQCIGRAVR 805
            ..||.|:|.||||...:.|.:..:||.|||..|.|       :|.|:|.....:||||.|||.:|
Human   636 TNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMKGQGGAGGQFLSGQEWYRQQASRAVNQAIGRVIR 700

  Fly   806 HIKDYACVYLLDKRFADPKIRGKLPKWISRHIVEANAANGGFGAVQGRTARFFK 859
            |.:||..|:|.|.|||....|.:||.|:..|:    .....||.|....|:||:
Human   701 HRQDYGAVFLCDHRFAFADARAQLPSWVRPHV----RVYDNFGHVIRDVAQFFR 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11403	NP_569898.1	DinG	15..841	CDD:224120	237/879 (27%)
		DEXDc2	16..394	CDD:214693	103/374 (28%)
		Helicase_C_2	659..836	CDD:290046	71/185 (38%)
RTEL1	NP_001269938.1	rad3	10..743	CDD:273169	240/890 (27%)
		P-loop_NTPase	15..>60	CDD:304359	20/48 (42%)
		DEAD_2	111..272	CDD:284209	60/179 (34%)
		Nuclear localization signal. /evidence=ECO:0000255\|HAMAP-Rule:MF_03065	151..167		3/19 (16%)
		DEAH box	250..253		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..306		2/18 (11%)
		Helicase_C_2	545..731	CDD:290046	71/185 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	757..786
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	839..877
		Nuclear localization signal. /evidence=ECO:0000255\|HAMAP-Rule:MF_03065	871..877
		HN_RTEL1	877..976	CDD:259826
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	979..1005
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1017..1054
		HN_RTEL1	1052..1138	CDD:259826
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1132..1151
		PIP-box	1178..1185
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820