DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11403 and rtel1

DIOPT Version :9

Sequence 1:	NP_569898.1	Gene:	CG11403 / 31072	FlyBaseID:	FBgn0026876	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_001013328.2	Gene:	rtel1 / 503732	ZFINID:	ZDB-GENE-050306-11	Length:	1177	Species:	Danio rerio

Alignment Length:	892	Identity:	228/892 - (25%)
Similarity:	350/892 - (39%)	Gaps:	207/892 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 FPYSPYEIQEQLMQELFQVLERGQVGIFESPTGTGKSLTLTCGALTWLARHEELVRTEMLARIRG 84
            ||::||..||..|.::.:.|::...|:.||||||||:|.|.|..|.|....::.:....:....|
Zfish    13 FPFTPYPCQEDYMSKVIECLQKKVNGVLESPTGTGKTLCLLCSTLAWRDHFKDTISARKITERMG 77

  Fly    85 VEQELAKLKEESEQSSNWLESQGKSRAQRAELLRLQHLQALLDKQEQQLDQIRKGAKKHKRQGRV 149
            ..:..|     ....|:|    |.:
Zfish    78 GAELFA-----DRPMSSW----GTA---------------------------------------- 93

  Fly   150 HPGKLEELEKDLDPESDSDSEHETADGPQEAAEDRYRPVQIFFCSRTHSQLAQIVAELRKTPHGQ 214
                          .:|.|:.....|.|           :|.:.|||||||.|:|.||:.|.:..
Zfish    94 --------------ATDGDTPTYYTDIP-----------KIIYASRTHSQLTQVVNELKNTSYRP 133

  Fly   215 SVRSISLGSRQQLCGNPAVRKLKHVGLMNERCLDMATKKARPNPSKKSRLTAEANSRCPFKAASL 279
            .:  ..||||:|||.|..|  ::|                ..|..|.....|:.:||......::
Zfish   134 KI--CVLGSREQLCINQEV--MRH----------------ESNHIKVHMCRAKVSSRSCIFYNNV 178

  Fly   280 VESLRDLALTEP-LDIEELANEGTACGGCSYYASRSAVEHAQLILLPYQLLLQKSARNQLGISLK 343
            .|...|..:... ||:|:|...|.....|.||.|||..:||.:|.:||..||...:|....|.||
Zfish   179 DEKSTDKEIVNSILDVEDLVKTGKKQRVCPYYLSRSLKQHADVIFMPYNYLLDPKSRRAHNIELK 243

  Fly   344 GSIVIVDEAHNL-----------------------LDSVAQLHGSEISRQQLERAKVQISGYKDH 385
            |::||.|||||:                       :|.:.:...|:||:.. ......:......
Zfish   244 GAVVIFDEAHNVEKMCEESTSFDLTPHDLISAIEAVDRLLREQASDISKAD-SAEDFNVESLNSG 307

  Fly   386 FQKRFTTKNLLKINQIIFIIRRLLKILDQRKELQSNGCSMMRTYELTAEGDFFNIDLCELLDFCA 450
            .:...||  :.|:.||:..:...:...:.....|.          :|..|.|. .:|.|:.:..:
Zfish   308 LKMDITT--IAKVKQILMDLETAINDFEMPANNQG----------ITKPGSFI-FELFEMANVNS 359

  Fly   451 RTRFARKVQGRADRMER-----EPRP-----SENQAPVSTARSLILQRLASEQKLKEKT----KS 501
            :|:     ....:.||:     ..||     :.....|:....|:.....:|...|.:|    |.
Zfish   360 KTK-----TETVEAMEQITGYLAGRPGVFLNTSGLQKVADIIQLVFVAEPAEGSKKSQTGNSLKE 419

  Fly   502 VKRRVEDINKEDKAEELQEQQKPTKKPVEEVAPSPIRPLLAFLETLTSNAEDGRILVDPVGGTLK 566
            .|..:...|...|           ||.:.:|..|            :|..:.|.:        |.
Zfish   420 FKVHIHPDNSNFK-----------KKQITDVWAS------------SSTKKQGNV--------LS 453

  Fly   567 YILLDPAEQFADIV-AEARAIVIAGGTMQPTKELKEQLFTGCHDRL---VERFYNHVVANDAILP 627
            |....|.....::: .|.|.|::..||:.|...     || |..::   |.....||:..|.|..
Zfish   454 YWCFSPGFSMQELLRQEVRCIILTSGTLSPLSS-----FT-CEMQIPFPVSLENPHVIQRDQIFV 512

  Fly   628 FVISNGPSGAPLSFKFAHRGSAEMLRELSMILRNLCQVVPGGVVCFLPSYEYLDKVYKYLEQSGT 692
            .:|..||.|..||..|..|...|.:..:...|.||.:|||.|::.|.|||..:||..::....|.
Zfish   513 SIIEKGPDGVQLSTAFDRRFVPENMSSMGNTLVNLSRVVPHGLLVFFPSYPVMDKTLEFWRAKGH 577

  Fly   693 LETISGRKSVFREV--SGSAEQLLDNYALAIKRPASYGALLLSVVGGKLSEGLNFADDLGRAVLV 755
            .:.|...|.:|.|.  .|:..:::|.|...:..|.|.|....:|..||.||||:|||..||.|::
Zfish   578 ADRIENVKPMFVEPRGKGTFTEVIDGYYGKVDDPNSSGGSFFAVCRGKASEGLDFADTYGRGVVI 642

  Fly   756 VGLPYSNSLSPELRQRMQHLDE----KLGPG----AGNEYYENLCVKAVNQCIGRAVRHIKDYAC 812
            .|||:...:.|.:..:||:|||    |:. |    .|.|:|.....:||||.|||.:||.:||..
Zfish   643 TGLPFPPRMDPRVVLKMQYLDEMCRNKIS-GVKYLTGQEWYRQQASRAVNQAIGRVIRHREDYGA 706

  Fly   813 VYLLDKRFADPKIRGKLPKWISRHIVEANAANGGFGAVQGRTARFFK 859
            ::|.|.||.....|.:||.|:..::    ....|||.:....|:||:
Zfish   707 IFLCDHRFKSADARNQLPSWVRPYV----KIYDGFGTMVRDVAQFFR 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11403	NP_569898.1	DinG	15..841	CDD:224120	222/872 (25%)
		DEXDc2	16..394	CDD:214693	97/397 (24%)
		Helicase_C_2	659..836	CDD:290046	70/186 (38%)
rtel1	NP_001013328.2	rad3	13..742	CDD:273169	225/883 (25%)
		DEAD_2	111..272	CDD:284209	59/180 (33%)
		Nuclear localization signal. /evidence=ECO:0000255\|HAMAP-Rule:MF_03065	151..167		4/31 (13%)
		DEAH box	250..253		2/2 (100%)
		Helicase_C_2	544..730	CDD:290046	70/186 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	847..869
		Nuclear localization signal. /evidence=ECO:0000255\|HAMAP-Rule:MF_03065	883..889
		HN_RTEL1	889..987	CDD:259826
		HN_RTEL1	1041..1144	CDD:259826
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820