DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11403 and ercc2

DIOPT Version :9

Sequence 1:	NP_569898.1	Gene:	CG11403 / 31072	FlyBaseID:	FBgn0026876	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_001008131.1	Gene:	ercc2 / 493493	XenbaseID:	XB-GENE-949792	Length:	760	Species:	Xenopus tropicalis

Alignment Length:	760	Identity:	188/760 - (24%)
Similarity:	316/760 - (41%)	Gaps:	155/760 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 ELEKDLDPESDSDSEHETADGPQEA------AEDRYRPVQI---FFCSRTHSQLAQIVAELRK-- 209
            ||::.||.:.....|..:..|...:      |..|..|:::   .:||||..::.::|.||||
Frog    27 ELKRTLDAKGHGVLEMPSGTGKTVSLLSLIVAYQRAYPLEVTKLIYCSRTVPEIEKVVEELRKLI 91

  Fly   210 ------TPHGQSVRSISLGSRQQLCGNPAVRKLKHVGLMNERCLDMATKKARPNPSKKSR-LTAE 267
                  |....:..:::|.||:.||.||.|..|:....::.||..:.....|   |:|.| .|.:
Frog    92 EYTQAQTGGTLNFMALALSSRRNLCVNPEVSALRFGKEIDGRCHSLTASFVR---SQKQRDPTVQ 153

  Fly   268 ANSRCPFKAASLVESLRDLALTEPL-----DIEELANEGTACGGCSYYASRSAVEHAQLILLPYQ 327
            .   |.|     .|....:....||     ::::|...|...|.|.||.:|.|:....:::..|.
Frog   154 T---CRF-----FEEFDAIGRETPLPPGIYNLDDLRTLGRQKGWCPYYLARHALGQCNVVVYSYH 210

  Fly   328 LLLQKSARNQLGISL-KGSIVIVDEAHNL----LDSVAQLHGSEISRQQLERAKVQISGYKDHFQ 387
            .||.....:.:...| |.|:|:.|||||:    :||::    ..|:|:.|||.:..|.......:
Frog   211 YLLDPKIADLVSRELSKKSVVVFDEAHNIDNVCIDSMS----VTITRRTLERCQTNIETLNTAIE 271

  Fly   388 KRFTTKNLLKINQIIFIIRRLLKILDQR--KELQSNGCSMMRTYELTAEGDFFNID-------LC 443
            |                    :|..|::  ||..:.....:|...:..|.|.:..:       |.
Frog   272 K--------------------IKETDEKKLKEEYAQLVEGLREASVARETDVYLSNPVLPDEILQ 316

  Fly   444 ELLDFCARTR-----FARKVQG------RADRMEREPRPSENQAPVSTARSLILQRLASEQK--- 494
            |.:..|.|..     |.|::.|      ||..:.:|       .|.:..|.| .:::..|:|
Frog   317 EAVPGCIRNALHFLGFLRRLVGYIKSRLRAGHVTQE-------GPAAFLRDL-YEKVCIERKPMR 373

  Fly   495 -LKEKTKSVKRRVEDINKEDKAEELQEQQKPTKKPVEEVAPSPIRPLLAFLETLTSNAEDGRILV 558
             ..|:.:|:.|.:|..:..|.                    ||:..:..|...:::..:...|::
Frog   374 FCAERLRSLTRTLEIADITDL--------------------SPLTLITNFATLVSTYTKGFMIII 418

  Fly   559 DPV--------GGTLKYILLDPAEQFADIVAEARAIVIAGGTMQPTKELKEQLFTGCHDRLVE-- 613
            :|.        ...|.:..||.:.....:....::::|..||:.|         ...:.::::
Frog   419 EPFEDRTPSISNPVLHFSCLDSSLAIKPVFQRFQSVIITSGTLSP---------LDIYPKILDFR 474

  Fly   614 ----RFYNHVVANDAILPFVISNGPSGAPLSFKFAHRGSAEMLRELSMILRNLCQVVPGGVVCFL 674
                ..:...:|...:.|.|:..|.....:|.||..|....::|....:|..:..|||.|:|.|.
Frog   475 PVTMATFTMTLARVCLCPMVVGRGNDQVAMSSKFETREDLAVMRNYGNLLLEMSAVVPDGIVGFF 539

  Fly   675 PSYEYLDKVYKYLEQSGTLETISGRKSVFREVSGSAEQ--LLDNYALAIKRPASYGALLLSVVGG 737
            .||.|::.:.....:.|.||.|...|.:|.|....||.  .|:.|..|.:.  ..||:||||..|
Frog   540 TSYLYMENIVASWYEQGILENIQRNKLIFIETQDGAETSVALEKYQEACEN--GRGAILLSVARG 602

  Fly   738 KLSEGLNFADDLGRAVLVVGLPYSNSLSPELRQRMQ------HLDEKLGPGAGNEYYENLCVKAV 796
            |:|||::|....||||::.|:||..:.|..|:.|:|      ||.|       |::.....::..
Frog   603 KVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLQFLRDQFHLRE-------NDFLTFDAMRHA 660

  Fly   797 NQCIGRAVRHIKDYACVYLLDKRFADPKIRGKLPKWISRHIVEAN 841
            .||:|||:|...||..:...|||:|....|||||.||..|:.:||
Frog   661 AQCVGRAIRGKTDYGIMLFADKRYARSDKRGKLPLWIQEHLTDAN 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11403	NP_569898.1	DinG	15..841	CDD:224120	186/758 (25%)
		DEXDc2	16..394	CDD:214693	69/265 (26%)
		Helicase_C_2	659..836	CDD:290046	68/184 (37%)
ercc2	NP_001008131.1	rad3	7..708	CDD:273169	188/760 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010