DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11403 and Rtel1

DIOPT Version :9

Sequence 1:	NP_569898.1	Gene:	CG11403 / 31072	FlyBaseID:	FBgn0026876	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_001178786.1	Gene:	Rtel1 / 362288	RGDID:	1306721	Length:	1274	Species:	Rattus norvegicus

Alignment Length:	894	Identity:	243/894 - (27%)
Similarity:	368/894 - (41%)	Gaps:	210/894 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 FPYSPYEIQEQLMQELFQVLERGQVGIFESPTGTGKSLTLTCGALTWLARHEELVRTEMLA-RIR 83
            ||:.||..|::.|.::.:.|::...||.||||||||:|.|.|..|.|.....:.|.:..:| |::
  Rat    13 FPFQPYPCQQEYMTKVLECLQKKVNGILESPTGTGKTLCLLCTTLAWREHLRDAVSSLKIAERVQ 77

  Fly    84 GVEQELAKLKEESEQSSNWLESQGKSRAQRAELLRLQHLQALLDKQEQQLDQIRKGAKKHKRQGR 148
            |   ||.    .|...|:|                                  |..|
  Rat    78 G---ELF----ASRTLSSW----------------------------------RSAA-------- 93

  Fly   149 VHPGKLEELEKDLDPESDSDSEHETADGPQEAAEDRYRPVQIFFCSRTHSQLAQIVAELRKTPHG 213
                           :::.||.....|.|           :|.:.|||||||.|::.|||.|.:.
  Rat    94 ---------------DANGDSIDCYTDIP-----------KIIYASRTHSQLTQVIGELRNTSYR 132

  Fly   214 QSVRSISLGSRQQLCGNPAVRKLKHVGLMNERCLDMATKKARPNPSKKSRLTAEANSRCPFKAAS 278
            ..|  ..||||:|||.:|.|:|.:    .|...:.:..||.             |:..|.|....
  Rat   133 PKV--CVLGSREQLCIHPEVKKQE----SNHMQISLCRKKV-------------ASRSCHFYNNV 178

  Fly   279 LVESLRDLALTEPLDIEELANEGTACGGCSYYASRSAVEHAQLILLPYQLLLQKSARNQLGISLK 343
            ..:||.....|..||||:|...|:....|.||.||:..:.|.:|.:||..||...:|....|.||
  Rat   179 EEKSLEQELATPILDIEDLVKNGSKHKVCPYYLSRNLKQQADIIFMPYNYLLDAKSRKAHNIDLK 243

  Fly   344 GSIVIVDEAHNLLDSVAQLHGSEISRQQLERAKVQISGYKDHFQKRFTTKNLLKINQIIFIIRRL 408
            |::||.||||| ::.:.:           |.|...::       .|.....|..|||::....|:
  Rat   244 GTVVIFDEAHN-VEKICE-----------ESASFDLT-------PRDVASGLEVINQVLEEQARV 289

  Fly   409 LKILDQRKELQ--------SNGCSMMRTYELTAEGDFFNIDLCELLDFCARTRFARKVQGRADRM 465
            .    |..|||        |:|.:|  ..|..|:.....:.|.|.:|       |.::.| .||.
  Rat   290 A----QHGELQQEFIIDTSSSGLNM--ELEDIAKLKMILLHLEEAID-------AVQLPG-DDRG 340

  Fly   466 EREPRP------SENQAPVSTARSL------ILQRLASEQKLKEKTKSVKRRVEDINKEDKAEEL 518
            ..:|..      :|.|....|...:      |:|.|.....:...|..:::.::.|......:.|
  Rat   341 VTKPGSYIFELFAEAQITFQTKGCILESLDQIIQHLTGRTGVFTNTAGLQKLMDIIQIVFSVDPL 405

  Fly   519 QEQQKPTKKPVEEVAPSP-------IRPLLAFLET-------------LTSNAEDGRILVDPVGG 563
            :      ..|..:|....       |.|     ||             .|::.:.|::
  Rat   406 E------GSPGSQVGLGSSHFYKVHIHP-----ETSHRRAAQRSDAWSTTASRKQGKV------- 452

  Fly   564 TLKYILLDPAEQFADIVAE-ARAIVIAGGTMQPTKE--LKEQL-FTGCHDRLVERFYNHVVANDA 624
             |.|....|:....::|.: .|.:::..||:.|...  |:.|: |..|.:.      .|::..:.
  Rat   453 -LSYWCFSPSHSMRELVQQGVRTLILTSGTLAPLSSFALEMQIPFPVCLEN------PHIIDKNQ 510

  Fly   625 ILPFVISNGPSGAPLSFKFAHRGSAEMLRELSMILRNLCQVVPGGVVCFLPSYEYLDKVYKYLEQ 689
            :...||..||.|..||..:..|.|.|.|..|...|.|:.:|||.|::.|.|||..::|..::.:.
  Rat   511 LWVGVIPRGPDGVQLSSAYDKRFSEECLSSLGKALGNIARVVPHGLLVFFPSYPVMEKSLEFWQA 575

  Fly   690 SGTLETISGRKSVFREV--SGSAEQLLDNYALAIKRPASYGALLLSVVGGKLSEGLNFADDLGRA 752
            .|..:.:...|.:|.|.  .||..:::|.|...:..|.|.||..|:|..||.||||:|:|..||.
  Rat   576 QGMSKKVEALKPLFVEPRNKGSFSEVIDAYYQQVASPGSNGATFLAVCRGKASEGLDFSDMNGRG 640

  Fly   753 VLVVGLPYSNSLSPELRQRMQHLDEKLGPG-------AGNEYYENLCVKAVNQCIGRAVRHIKDY 810
            |:|.||||...:.|.:..:||.|||..|..       :|.|:|:....:||||.|||.:||..||
  Rat   641 VIVTGLPYPPRMDPRVILKMQFLDEMKGRSRVGGQCLSGQEWYQQQASRAVNQAIGRVIRHRHDY 705

  Fly   811 ACVYLLDKRFADPKIRGKLPKWISRHIVEANAANGGFGAVQGRTARFFK 859
            ..::|.|.|||....|..||.|:..::    .....||.|....|:||:
  Rat   706 GAIFLCDHRFAYADARAHLPSWVRPYL----KVYDNFGRVIRDVAQFFR 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11403	NP_569898.1	DinG	15..841	CDD:224120	237/874 (27%)
		DEXDc2	16..394	CDD:214693	102/374 (27%)
		Helicase_C_2	659..836	CDD:290046	71/185 (38%)
Rtel1	NP_001178786.1	rad3	10..743	CDD:273169	240/885 (27%)
		P-loop_NTPase	15..>86	CDD:304359	27/77 (35%)
		DEAD_2	111..272	CDD:284209	64/198 (32%)
		Nuclear localization signal. /evidence=ECO:0000255\|HAMAP-Rule:MF_03065	151..167		3/19 (16%)
		DEAH box	250..253		2/2 (100%)
		Helicase_C_2	545..731	CDD:290046	71/185 (38%)
		Nuclear localization signal. /evidence=ECO:0000255\|HAMAP-Rule:MF_03065	871..877
		HN_RTEL1	877..976	CDD:259826
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	982..1002
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1014..1038
		HN_RTEL1	1035..1137	CDD:259826
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1143..1198
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820