DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11403 and Brip1

DIOPT Version :9

Sequence 1:	NP_569898.1	Gene:	CG11403 / 31072	FlyBaseID:	FBgn0026876	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_840094.1	Gene:	Brip1 / 237911	MGIID:	2442836	Length:	1174	Species:	Mus musculus

Alignment Length:	969	Identity:	254/969 - (26%)
Similarity:	392/969 - (40%)	Gaps:	249/969 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 TPGAQEFGFPYSPYEIQEQLMQELFQVLERGQVGIFESPTGTGKSLTLTCGALTWLARHEELVRT 76
            |.|..:..||...|..|..:|..:.:.|...|..:.|||||:||||.|.|.||.|.....|
Mouse     9 TIGGVKIHFPCRAYPAQLAMMNSIVRGLNSSQHCLLESPTGSGKSLALLCSALAWQQSLSE---- 69

  Fly    77 EMLARIRGVEQELAKLKEESEQS-------------------SNWLESQGKSRAQR--------- 113
                  :.|::.|.| |.|:..|                   |....|..|..:.|
Mouse    70 ------KPVDEGLNK-KPEAPPSCSCACHSKNFTYSDTNLDTSPHFNSPSKPSSGRNGVSTPCQD 127

  Fly   114 --------AELLRLQHLQALLDKQEQQLDQIRKG-----------AKKHKRQGRVH--PGKLEEL 157
                    |:|...:  ||.:.:.|....|:.|.           .|:|..:..||  ..:|..
Mouse   128 SPEKNTLAAKLSAKK--QASIHRDEDDDFQVEKKRIRPLETTQQIRKRHCLEKDVHHVDARLAS- 189

  Fly   158 EKDLDPE-------SDSDSEHETADG-------------PQEAA----EDR----YRPVQIFFCS 194
            ||.:.||       ||.....:..||             .||.|    :|.    .|| :|:|.:
Mouse   190 EKRVKPESPIGKSFSDRKDSFQNVDGLCSRCCCSAKQGNNQEPANTVKKDHGGQCKRP-KIYFGT 253

  Fly   195 RTHSQLAQIVAELRKTPHGQSVRSISLGSRQQLCGNPAVRKLKHVGLMN--ERCLDMATKKARPN 257
            |||.|:|||..|||||.: ..|....|.||...|.:|.|     ||..|  |:|:::
Mouse   254 RTHKQIAQITRELRKTAY-SGVPMTILSSRDHSCVHPEV-----VGNFNRKEKCMEL-------- 304

  Fly   258 PSKKSRLTAEANSRCPF----KAASLVESLRDL-ALTEPLDIEELANEGTACGGCSYYASRSAVE 317
                  |..:....|.|    ...|..::|:.| .::...|||||.:.|.....|.||.:|..:|
Mouse   305 ------LDGKHGKSCYFYHGVHKISNQQTLQHLQGMSRAWDIEELVSLGRKLKACPYYTARELIE 363

  Fly   318 HAQLILLPYQLLLQKSARNQLGISLKGSIVIVDEAHNLLDSVAQLHGSEISRQQLERAKVQISGY 382
            .|.::..||..||....|..:.|.|||.:||:|||||:.|...:.....::..||..|:.::...
Mouse   364 DADIVFCPYNYLLDSQIRETMDIKLKGQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSL 428

  Fly   383 -------KDHFQKRFTTKNLLKINQIIFIIRRLLKILDQRKELQSNGCSMM-RTYELTAE---GD 436
                   |.|...|....||:                   ..|::|...:: |.||.:.:   |:
Mouse   429 INGNIRKKSHEPLRDVCYNLI-------------------NWLETNSKHLVERGYESSCKIWSGN 474

  Fly   437 FFNIDLCELLDFCARTRFARKVQGRADRMEREPRPSENQAPVSTARSLILQRLASEQKLKEKTKS 501
            ...::|..:                               .::||...:|||..|..
Mouse   475 EMLLNLYRM-------------------------------GITTATFPVLQRHLSAV-------- 500

  Fly   502 VKRRVEDINKEDKAEELQEQQKPTKKPVEEVAPSPI-RPLLAFLETL----TSNAEDGRILV--- 558
                   :.||:|...:..:::..:.|:...:...: :.|...|:.|    :..|:|.::.:
Mouse   501 -------LQKEEKVTPIHGKEEAIQIPIISASTQVVLKGLFMVLDYLFRENSRFADDYKVAIQQT 558

  Fly   559 ----------DPVG-----------------GTLKYILLDPAEQFADIVAEARAIVIAGGTMQPT 596
                      |..|                 ..|.:..|:||..|:||..:.|.||:..||:.|.
Mouse   559 YSWTNQIAIFDKTGVLAVPKNKKHSRQKIGVNALNFWCLNPAVAFSDINDKVRTIVLTSGTLSPL 623

  Fly   597 KELKEQL---FTGCHDRLVERFYNHVVANDAILPFVISNGPSGAPLSFKFAHRGSAEMLRELSMI 658
            |....:|   |:      ::...|||::|..:....:.:||.|..|...|.|..:.|...|:.|:
Mouse   624 KSFSSELGVTFS------IQLEANHVISNSQVWVGTVGSGPKGRNLCATFQHTETFEFQDEVGML 682

  Fly   659 LRNLCQVVPGGVVCFLPSYEYLDKVYKYLEQSGTLETISGRKSVFREVSGSA----EQLLDNYAL 719
            |.::||.|..|::||||||:.|:|:.:....:|...::...|:|..|..|..    ::||..|..
Mouse   683 LLSVCQTVSQGILCFLPSYKLLEKLRERWIFTGLWHSLESVKTVIAEPQGGEKTDFDELLQVYYD 747

  Fly   720 AIK-RPASYGALLLSVVGGKLSEGLNFADDLGRAVLVVGLPYSN--SLSPEL-RQRMQHLDEKLG 780
            ||| :....||||::|..||:||||:|:||..|||:.||:|:.|  .|..|| ||...|..:..|
Mouse   748 AIKFKGEKDGALLIAVCRGKVSEGLDFSDDNARAVITVGIPFPNVKDLQVELKRQYNDHHSKSRG 812

  Fly   781 PGAGNEYYENLCVKAVNQCIGRAVRHIKDYACVYLLDKRFADPKIR--GKLPKWISRHI 837
            ...|.::||....:|:||.:||.:||..|:..:.|:|.||.:...|  ..|.||:.:.|
Mouse   813 LLPGRQWYEIQAYRALNQALGRCIRHKNDWGALILVDDRFNNNPNRYISGLSKWVRQQI 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11403	NP_569898.1	DinG	15..841	CDD:224120	252/966 (26%)
		DEXDc2	16..394	CDD:214693	125/468 (27%)
		Helicase_C_2	659..836	CDD:290046	71/186 (38%)
Brip1	NP_840094.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..160		11/60 (18%)
		Nuclear localization signal. /evidence=ECO:0000255	158..175		2/16 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..208		7/21 (33%)
		rad3	248..884	CDD:273169	194/715 (27%)
		DEAD_2	251..418	CDD:284209	60/186 (32%)
		DEAH box	393..396		2/2 (100%)
		Helicase_C_2	683..869	CDD:290046	71/185 (38%)
		Interaction with BRCA1. /evidence=ECO:0000250	888..1063
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	923..1001
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1102..1155
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820