DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11403 and ERCC2

DIOPT Version :9

Sequence 1:	NP_569898.1	Gene:	CG11403 / 31072	FlyBaseID:	FBgn0026876	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_000391.1	Gene:	ERCC2 / 2068	HGNCID:	3434	Length:	760	Species:	Homo sapiens

Alignment Length:	746	Identity:	179/746 - (23%)
Similarity:	318/746 - (42%)	Gaps:	123/746 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 LEELEKDLDPESDSDSEHETADGPQEA------AEDRYRPVQI---FFCSRTHSQLAQIVAELRK 209
            :.||::.||.:.....|..:..|...:      |..|..|:::   .:||||..::.:::.||||
Human    25 MRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRK 89

  Fly   210 ------TPHGQSV--RSISLGSRQQLCGNPAVRKLKHVGLMNERCLDMATKKARPNPSKKSRLTA 266
                  ...|:.:  ..::|.||:.||.:|.|..|:....::.:|..:.....|......:.|
Human    90 LLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSL-- 152

  Fly   267 EANSRCPFKAASLVESL----RDLALTEPL-DIEELANEGTACGGCSYYASRSAVEHAQLILLPY 326
               ..|.|     .|..    |::.|...: ::::|...|...|.|.|:.:|.::.||.:::..|
Human   153 ---PHCRF-----YEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSY 209

  Fly   327 QLLLQKSARNQLGISL-KGSIVIVDEAHNL----LDSVAQLHGSEISRQQLERAKVQISGYKDHF 386
            ..||.....:.:...| :.::|:.|||||:    :||::    ..::|:.|:|.:    |..:..
Human   210 HYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMS----VNLTRRTLDRCQ----GNLETL 266

  Fly   387 QKRFTTKNLLKINQIIFIIRRLLKILDQRKELQSNGCSMMRTYELTAEGDFFNIDLCELLDFCAR 451
            ||.              ::|  :|..|:::        :...|....||         |.:..|
Human   267 QKT--------------VLR--IKETDEQR--------LRDEYRRLVEG---------LREASA- 297

  Fly   452 TRFARKVQGR------ADRMEREPRPSENQAPVSTARSLI--LQRLASEQKLKEKTKSVKRRVED 508
               ||:....      .|.:.:|..|..    :.||...:  |:||....|.:.:.:.|.:....
Human   298 ---ARETDAHLANPVLPDEVLQEAVPGS----IRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPP 355

  Fly   509 INKEDKAEELQEQQKPTKKPVEEVAP-------------SPIRPLLAFLETLTSNAEDGRILVDP 560
            ......|:.:..|:||.:...|.:..             ||:..|..|...:::.|:...|:::|
Human   356 AFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEP 420

  Fly   561 --------VGGTLKYILLDPAEQFADIVAEARAIVIAGGTMQPTKELKEQLFTGCHDRLVERFYN 617
                    ....|.:..:|.:.....:....::::|..||:.|.....:.|  ..|...:..| .
Human   421 FDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKIL--DFHPVTMATF-T 482

  Fly   618 HVVANDAILPFVISNGPSGAPLSFKFAHRGSAEMLRELSMILRNLCQVVPGGVVCFLPSYEYLDK 682
            ..:|...:.|.:|..|.....:|.||..|....::|....:|..:..|||.|:|.|..||:|::.
Human   483 MTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMES 547

  Fly   683 VYKYLEQSGTLETISGRKSVFREVSGSAEQ--LLDNYALAIKRPASYGALLLSVVGGKLSEGLNF 745
            ......:.|.||.|...|.:|.|....||.  .|:.|..|.:.  ..||:||||..||:|||::|
Human   548 TVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACEN--GRGAILLSVARGKVSEGIDF 610

  Fly   746 ADDLGRAVLVVGLPYSNSLSPELRQRMQHLDEKLGPGAGNEYYENLCVKAVNQCIGRAVRHIKDY 810
            ....||||::.|:||..:.|..|:.|:::|.::. ....|::.....::...||:|||:|...||
Human   611 VHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQF-QIRENDFLTFDAMRHAAQCVGRAIRGKTDY 674

  Fly   811 ACVYLLDKRFADPKIRGKLPKWISRHIVEAN 841
            ..:...|||||....|||||:||..|:.:||
Human   675 GLMVFADKRFARGDKRGKLPRWIQEHLTDAN 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11403	NP_569898.1	DinG	15..841	CDD:224120	177/744 (24%)
		DEXDc2	16..394	CDD:214693	60/266 (23%)
		Helicase_C_2	659..836	CDD:290046	66/178 (37%)
ERCC2	NP_000391.1	rad3	7..708	CDD:273169	179/746 (24%)
		DEAH box	234..237		2/2 (100%)
		Mediates interaction with MMS19	438..637		60/203 (30%)
		Nuclear localization signal. /evidence=ECO:0000255	682..695		8/12 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820