Protein Alignment CG11403 and Ercc2

DIOPT Version :10

• Sequence 1: NP_569898.1
• Gene: CG11403 / 31072
• FlyBaseID: FBgn0026876
• Length: 861
• Species: Drosophila melanogaster
• Sequence 2: NP_031975.2
• Gene: Ercc2 / 13871
• MGIID: 95413
• Length: 760
• Species: Mus musculus
• Alignment Length: 740
• Identity: 177/740 - (23%)
• Similarity: 316/740 - (42%)
• Gaps: 115/740 - (15%)

  Fly   156 ELEKDLDPESDSDSEHETADGPQEA------AEDRYRPVQI---FFCSRTHSQLAQIVAELRK-- 209
            ||::.||.:.....|..:..|...:      |..|..|:::   .:||||..::.:::.||||
Mouse    27 ELKRTLDAKGHGVLEMPSGTGKTVSLLALIVAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLL 91

  Fly   210 ----TPHGQSV--RSISLGSRQQLCGNPAVRKLKHVGLMNERCLDMATKKARPNPSKKSRLTAEA 268
                ...|:.:  ..::|.||:.||.:|.|..|:....::.:|..:.....|....:.:.|
Mouse    92 SFYEQQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQQDASL---- 152

  Fly   269 NSRCPFKAASLVESLRDLALTEPL-DIEELANEGTACGGCSYYASRSAVEHAQLILLPYQLLLQK 332
             ..|.|.....:.. |.:.|...: ::::|...|...|.|.|:.:|.::.||.:::..|..||..
Mouse   153 -PHCRFYEEFDIHG-RQMPLPAGIYNLDDLKALGQRQGWCPYFLARYSILHANVVVYSYHYLLDP 215

  Fly   333 SARNQLGISL-KGSIVIVDEAHNL----LDSVAQLHGSEISRQQLERAKVQISGYKDHFQKRFTT 392
            ...:.:...| :.::|:.|||||:    :||::    ..::|:.|:|.:..:    |..||.
Mouse   216 KIADLVSKELARKAVVVFDEAHNIDNVCIDSMS----VNLTRRTLDRCQSNL----DTLQKT--- 269

  Fly   393 KNLLKINQIIFIIRRLLKILDQRKELQSNGCSMMRTYELTAEGDFFNIDLCELLDFCARTRFARK 457
                       ::|  :|..|:::        :...|....||             ......||:
Mouse   270 -----------VLR--IKETDEQR--------LRDEYRRLVEG-------------LREASVARE 300

  Fly   458 VQGR------ADRMEREPRPSENQAPVSTARSLI--LQRLASEQKLKEKTKSVKRRVEDINKEDK 514
            ....      .|.:.:|..|..    :.||...:  |:||....|.:.:.:.|.:..........
Mouse   301 TDAHLANPVLPDEVLQEAVPGS----IRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGL 361

  Fly   515 AEELQEQQKPTKKPVE---------EVAP----SPIRPLLAFLETLTSNAEDGRILVDP------ 560
            |:.:..|:||.:...|         |:|.    ||:..|..|...:::.|:...|:::|
Mouse   362 AQRVCIQRKPLRFCAERLRSLLHTLEIADLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTP 426

  Fly   561 --VGGTLKYILLDPAEQFADIVAEARAIVIAGGTMQPTKELKEQLFTGCHDRLVERFYNHVVAND 623
              ....|.:..:|.:.....:....::::|..||:.|.....:.|  ..|...:..| ...:|..
Mouse   427 TIANPVLHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKIL--DFHPVTMATF-TMTLARV 488

  Fly   624 AILPFVISNGPSGAPLSFKFAHRGSAEMLRELSMILRNLCQVVPGGVVCFLPSYEYLDKVYKYLE 688
            .:.|.:|..|.....:|.||..|....::|....:|..:..|||.|:|.|..||:|::.......
Mouse   489 CLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWY 553

  Fly   689 QSGTLETISGRKSVFREVSGSAEQ--LLDNYALAIKRPASYGALLLSVVGGKLSEGLNFADDLGR 751
            :.|.||.|...|.:|.|....||.  .|:.|..|.:.  ..||:||||..||:|||::|....||
Mouse   554 EQGILENIQRNKLLFIETQDGAETSVALEKYQEACEN--GRGAILLSVARGKVSEGIDFVHHYGR 616

  Fly   752 AVLVVGLPYSNSLSPELRQRMQHLDEKLGPGAGNEYYENLCVKAVNQCIGRAVRHIKDYACVYLL 816
            ||::.|:||..:.|..|:.|:::|.::. ....|::.....::...||:|||:|...||..:...
Mouse   617 AVIMFGVPYVYTQSRILKARLEYLRDQF-QIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFA 680

  Fly   817 DKRFADPKIRGKLPKWISRHIVEAN 841
            |||||....|||||:||..|:.::|
Mouse   681 DKRFARADKRGKLPRWIQEHLTDSN 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11403	NP_569898.1	DEAD-like_helicase_N	42..>101	CDD:475120
		rad3	187..837	CDD:273169	167/697 (24%)
Ercc2	NP_031975.2	rad3	7..708	CDD:273169	177/740 (24%)
		DEAH box	234..237		2/2 (100%)
		Mediates interaction with MMS19. /evidence=ECO:0000250	438..637		60/203 (30%)