Protein Alignment CG3638 and TTYH3

DIOPT Version :10

• Sequence 1: NP_726720.3
• Gene: CG3638 / 31071
• FlyBaseID: FBgn0261444
• Length: 1472
• Species: Drosophila melanogaster
• Sequence 2: NP_079526.1
• Gene: TTYH3 / 80727
• HGNCID: 22222
• Length: 523
• Species: Homo sapiens
• Alignment Length: 612
• Identity: 140/612 - (22%)
• Similarity: 241/612 - (39%)
• Gaps: 153/612 - (25%)

  Fly     8 VKILHSIPHVNYTFRRVNDTFNPDSDVYLESLVILASIPAGLLIGSLLGLLLYLLTRCCDRRQRK 72
            |.:||.:||.:.::...:..|.|:...|.::|::|.:.....|...||.||.|....||.||:.:
Human    12 VSLLHRLPHFDLSWEATSSQFRPEDTDYQQALLLLGAAALACLALDLLFLLFYSFWLCCRRRKSE 76

  Fly    73 PSAQR---CQSCSLVIITLMTCAAIGLGLYGNDDFHNGLLQAFGS----GKSVEGL-------VL 123
            .....   |.:..::|.||:..|.|.:|.|||.:..:|:.:|..|    .::|.|:       .:
Human    77 EHLDADCCCTAWCVIIATLVCSAGIAVGFYGNGETSDGIHRATYSLRHANRTVAGVQDRVWDTAV 141

  Fly   124 TLKRQTESIKHDLETRMAGHKVEQLVEKPHYNQTVVMLLIETSRLVTENTSRAVASLDSMVHYFM 188
            .|....|.....||.::||        :|           |..|.|    .|....|::::.|..
Human   142 GLNHTAEPSLQTLERQLAG--------RP-----------EPLRAV----QRLQGLLETLLGYTA 183

  Fly   189 KAKGSEND-TSLMGLLQLGEFYESIRWPATLAFLTVLLLLCTVLVIGVARRSRCTLIFFSVSGLF 252
            ......|. .||..|.:..:.|:..||...|..|.:.:::|.::::|:.|.|:..|:...:.|:.
Human   184 AIPFWRNTAVSLEVLAEQVDLYDWYRWLGYLGLLLLDVIICLLVLVGLIRSSKGILVGVCLLGVL 248

  Fly   253 CIIICWLLAGVYLASSVAAGDFCMRPHDYMCRQV-------GMRSPYVDFLNCGTPR--NRFILR 308
            .::|.|...|:.||.||.:.|||:.|..|:.:.|       |....|  :|.| :||  |.|..:
Human   249 ALVISWGALGLELAVSVGSSDFCVDPDAYVTKMVEEYSVLSGDILQY--YLAC-SPRAANPFQQK 310

  Fly   309 LN-------ESRDLVDRARESVEHMQRMSQETYPHIDIQRTLNAMDNDLEITLRNLTTLSATLDR 366
            |:       |.:|:|.....:|...|..:::  |.:.:|..||.    .|:.|::||.|   :|.
Human   311 LSGSHKALVEMQDVVAELLRTVPWEQPATKD--PLLRVQEVLNG----TEVNLQHLTAL---VDC 366

  Fly   367 RTIDMHYEEALRGLCGGGLLGLSLMMVAGLLTSFLLTILVYADSHAWIYLTKRPTLDADKSETAP 431
            |::.:.|.:||.|.|..|:.||..:.:...:|:.:.:.:|.:..|.|  ..||...:..:.|.||
Human   367 RSLHLDYVQALTGFCYDGVEGLIYLALFSFVTALMFSSIVCSVPHTW--QQKRGPDEDGEEEAAP 429

  Fly   432 LFPASNAPSASISPTAPLSTGTINRTLLHHQQASSGGGSGTLPGSGGGAGAGGGVGANGHNGVGP 496
                           .|             :||                          |:.:
Human   430 ---------------GP-------------RQA--------------------------HDSL-- 438

  Fly   497 YRNGSAGLRQGLASPSSQSSHTSSTATYNNGTTSYHNSHQQHNNHLYSNHYSHSNNHYNNTQHRT 561
            ||.....|....:|..|::|..::..|.:|...:               .|...|.::.|.:...
Human   439 YRVHMPSLYSCGSSYGSETSIPAAAHTVSNAPVT---------------EYMSQNANFQNPRCEN 488

  Fly   562 NPAAGAVAAAVGVVSSGQRSPSPPPVY 588
            .|..|              ..||||.|
Human   489 TPLIG--------------RESPPPSY 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3638	NP_726720.3	Tweety	4..438	CDD:461475	118/460 (26%)
TTYH3	NP_079526.1	Tweety	8..435	CDD:461475	121/513 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	413..435		9/77 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	482..523		8/34 (24%)
		PY-motif, mediates interaction with NEDD4L. /evidence=ECO:0000250|UniProtKB:Q9BSA4	498..501		2/2 (100%)