Protein Alignment CG3638 and TTYH1

DIOPT Version :10

• Sequence 1: NP_726720.3
• Gene: CG3638 / 31071
• FlyBaseID: FBgn0261444
• Length: 1472
• Species: Drosophila melanogaster
• Sequence 2: NP_001005367.1
• Gene: TTYH1 / 57348
• HGNCID: 13476
• Length: 460
• Species: Homo sapiens
• Alignment Length: 473
• Identity: 126/473 - (26%)
• Similarity: 223/473 - (47%)
• Gaps: 57/473 - (12%)

  Fly     3 QPSILVKILHSIPHVNYTFRRVNDTFNPDSDVYLESLVILASIPAGLLIG-SLLGLLLYLLTRCC 66
            :||..|.:||.:|..::..|.|...|.|....|.::|:::|:: |||.:| ||:.:.:||:..||
Human     8 RPSAWVHLLHQLPRADFQLRPVPSVFAPQEQEYQQALLLVAAL-AGLGLGLSLIFIAVYLIRFCC 71

  Fly    67 DRRQRKPSAQ------RCQSCSLVIITLMTCAAIGLGLYGNDDFHNG-------LLQAFGSGKSV 118
            .|....|.::      .|.:.|.::..|..|..||:|.|||.:..:|       ||.|..:..::
Human    72 CRPPEPPGSKIPSPGGGCVTWSCIVALLAGCTGIGIGFYGNSETSDGVSQLSSALLHANHTLSTI 136

  Fly   119 EGLVL-TLKRQTESIKHDLETRMAGHKVEQLVEKPHYNQTVVMLLIETSRLVTENTSRAVASLDS 182
            :.||| |::|..|:::.:|.|      :|:::| |...      |:..:|........|...|..
Human   137 DHLVLETVERLGEAVRTELTT------LEEVLE-PRTE------LVAAARGARRQAEAAAQQLQG 188

  Fly   183 MVHYFMKAKGSENDTSLMGLLQLGE---FYESIRWPATLAFLTVLLLLCTVLVIGVARRSRCTLI 244
            :..:    :|..     :..||:.|   |.|..||.|.:..|.:.||:|...::|:|::|:..:|
Human   189 LAFW----QGVP-----LSPLQVAENVSFVEEYRWLAYVLLLLLELLVCLFTLLGLAKQSKWLVI 244

  Fly   245 FFSVSGLFCIIICWLLAGVYLASSVAAGDFCMRPHDYMC----RQVGMRSPYVD-FLNCG-TPRN 303
            ..:|..|..:::.|...|:..|::|...|||..|..|:.    .:.|:.|..:. :|.|. ...|
Human   245 VMTVMSLLVLVLSWGSMGLEAATAVGLSDFCSNPDPYVLNLTQEETGLSSDILSYYLLCNRAVSN 309

  Fly   304 RFILRLNESRDLVDRARESVEHMQRMSQETYPHIDIQRTLNAMDNDLEITLRNLTTLSATLDRRT 368
            .|..||..|:..:......:..::|.:...:|  ..|:.|.:::..|.:|..|...|.|.|..|:
Human   310 PFQQRLTLSQRALANIHSQLLGLEREAVPQFP--SAQKPLLSLEETLNVTEGNFHQLVALLHCRS 372

  Fly   369 IDMHYEEALRGLCGGGLLGLSLMMVAGLLTSFLLTILVYADSHAW-IYLTKRPT-LDADKSETAP 431
            :...|..||||||...|.||..:::..||::..|...:.:...|| ::..:.|: |.:....:.|
Human   373 LHKDYGAALRGLCEDALEGLLFLLLFSLLSAGALATALCSLPRAWALFPPRNPSALCSGSRLSEP 437

  Fly   432 LFPASNAPSASISPTAPL 449
            |.|      |.:.|.:||
Human   438 LLP------AGLEPGSPL 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3638	NP_726720.3	Tweety	4..438	CDD:461475	122/459 (27%)
TTYH1	NP_001005367.1	Tweety	9..424	CDD:461475	117/439 (27%)