Protein Alignment CG3638 and Ttyh2

DIOPT Version :9

• Sequence 1: NP_726720.3
• Gene: CG3638 / 31071
• FlyBaseID: FBgn0261444
• Length: 1472
• Species: Drosophila melanogaster
• Sequence 2: NP_444503.2
• Gene: Ttyh2 / 117160
• MGIID: 2157091
• Length: 532
• Species: Mus musculus
• Alignment Length: 611
• Identity: 154/611 - (25%)
• Similarity: 239/611 - (39%)
• Gaps: 151/611 - (24%)

  Fly    11 LHSIPHVNYTFRRVNDTFNPDSDVYLESLV---ILASIPAGLLIGSLLGLLLYLLTRCCDRRQRK 72
            |||:||:....:||:.||:|..:.|.|||:   :||:|..||   :|:.|.:||:..||.||...
Mouse    17 LHSVPHLGLRLQRVDSTFSPGDETYQESLLFLGVLAAIGLGL---NLIFLTVYLVCTCCCRRDHT 78

  Fly    73 PSAQRCQSC----SLVIITLMTCAAIGLGLYGNDDFHNGLLQAF----GSGKSVEGLVLTLKRQT 129
            ...::.:||    :.|:..|:.|||:|:|.|||.:.::|:.|..    .:..:..|:...:...|
Mouse    79 VQTKQQESCCVTWTAVVAGLLCCAAVGVGFYGNSETNDGMHQLIYSLDNANHTFSGMDELVSANT 143

  Fly   130 ESIKHDLETRMAGHKVEQLVEKPHYNQTVVMLLIETSRLVTENTSRAVASLDSMVHYFMKAKGSE 194
            :.:|.|||..:| ...|.:..:..|        |:|.:.:.:.....|:.|..:..:      .|
Mouse   144 QRMKVDLEQHLA-RLSEIIAARGDY--------IQTLKFMQQMAGNVVSQLSGLPVW------RE 193

  Fly   195 NDTSLMGLLQLGEFYESIRWPATLAFLTVLLLLCTVLVIGVARRSRCTLIFFSVSGLFCIIICWL 259
            ..|.|..|.....:.|..||.:.|....:.|::|.|..:|:||||:|.|......|:..:|:.|.
Mouse   194 VTTQLTKLSHQTAYVEYYRWLSYLLLFILDLVICLVTCLGLARRSKCLLASMLCCGILTLILSWA 258

  Fly   260 LAGVYLASSVAAGDFCMRPHDYMCRQVGMRSPYVDFLNCGTPRNRFILR--LNESRDLVDRARES 322
            ......|::|...||||.|..|:..            |.|:..|..:.|  |:.|:.|:...::|
Mouse   259 SLAADAAAAVGTSDFCMAPDIYILN------------NTGSQINSEVTRYYLHCSQSLISPFQQS 311

  Fly   323 VEHMQR-----------MSQETYP--------HIDIQRTLNAMDNDLEITLRNLTTLSATLDRRT 368
            :...||           :.|...|        .:.||..|    |:.||:|..||   |.||.|.
Mouse   312 LTTFQRSLTTMQIQVGGLLQFAVPLFPTAEKDLLGIQLLL----NNSEISLHQLT---AMLDCRG 369

  Fly   369 IDMHYEEALRGLCGGGLLGLSLMMVAGLLTSFLLTILVYADSHAWIYLTKRPTLDADKSETAPLF 433
            :...|.:||.|:|..|:.||..:.:..||.:...:.|..|...||.|...|.....|..:..|..
Mouse   370 LHKDYLDALTGICYDGIEGLLFLGLFSLLAALAFSTLTCAGPRAWKYFINRDRDYDDIDDDDPFN 434

  Fly   434 PASNAPSASISPTAPLSTGTINRTLLH-HQQASSGGGSGTLPGSGGGAGAGGGVGANGHNGVGPY 497
            |.:...:|. :||         |..|| ....|||.||
Mouse   435 PQARRIAAH-NPT---------RGQLHSFCSYSSGLGS--------------------------- 462

  Fly   498 RNGSAGLRQGLASPSSQSSHTSSTATYNNGTTSYHNSHQQHNNHLYSNHYSHSNNHYNNTQHRTN 562
                    |....|.||:...:..:.|.|....:                 ..|..|.|
Mouse   463 --------QCSLQPPSQTISNAPVSEYMNQAILF-----------------GGNPRYEN------ 496

  Fly   563 PAAGAVAAAVGVVSSGQRSPSPPPVY 588
                     |.::..|    ||||.|
Mouse   497 ---------VPLIGRG----SPPPTY 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3638	NP_726720.3	Tweety_N	1..421	CDD:143653	124/441 (28%)
Ttyh2	NP_444503.2	Tweety	27..419	CDD:282726	118/428 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845563
Domainoid	1	1.000	170	1.000	Domainoid score	I3757
eggNOG	1	0.900	-	-		E1_KOG4433
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3894
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48395
OrthoDB	1	1.010	-	-		D318605at33208
OrthoFinder	1	1.000	-	-		FOG0000987
OrthoInspector	1	1.000	-	-		mtm8906
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12424
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X806
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.870