DRSC/TRiP Functional Genomics Resources

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Protein Alignment HLA-B and mhc1ula

DIOPT Version :10

Sequence 1:XP_054186779.1 Gene:HLA-B / 3106 HGNCID:4932 Length:405 Species:Homo sapiens
Sequence 2:NP_001304679.1 Gene:mhc1ula / 796419 ZFINID:ZDB-GENE-130814-1 Length:344 Species:Danio rerio


Alignment Length:315 Identity:97/315 - (30%)
Similarity:158/315 - (50%) Gaps:21/315 - (6%)


- Green bases have known domain annotations that are detailed below.


Human    68 GSHSMRYFYTAMSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRMAPRAPWI-EQEGPEYWDRET 131
            |.|.:...||.: |.....|.||||..:|..|...:||  .:.::.|:..|: |....|.|..:.
Zfish    16 GYHGLITTYTGI-RGASETPIFIAVAILDGEQIDYYDS--VTNKLIPKQDWMKEYASEEIWKEDC 77

Human   132 QISKTNTQTYRESLRNLRGYYNQSEAGSHTLQRMYGCDVGPDGRLLRGHDQSAYDGKDYIALNED 196
            :|.....|.||.::..|...:|||. |.|..|||||||...:.....|.||..|||:||:.|:..
Zfish    78 KIRGDVHQIYRSNINVLMQRFNQSN-GVHVYQRMYGCDWDEETEESHGFDQYGYDGEDYVMLDMR 141

Human   197 LSSWTAADTAAQITQRKWEAARE-AEQWRAYLEGLCVEWLRRYLENGKETLQRADPPKTHVTHHP 260
            ...:.......:||.:||.:.|| .:..:.|.:..||.||:::|...|..|:..||....:..:|
Zfish   142 EIRYITPVQQGEITVQKWNSNREQLKTLQHYYKYECVYWLKQFLGLRKADLEIRDPEVFLLQKNP 206

Human   261 ISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQR-- 323
            .|..|    |:|.||||:.:.:||.::|:|..::.||.|.:|..|.|||:.:::.|...:.::  
Zfish   207 SSPVE----CFATGFYPSGVIITWLKNGQDHGENVELRELKPNEDGTFQRSSSLHVSQEDWKKSL 267

Human   324 YTCHVQHEGLPKPLTLRW---EPSSQSTIPIVGIVAGLAVLAVVVIGAVVATVMC 375
            |||.|:|:    .:|::.   |..|.|:..:  .:....|||:::...|:...:|
Zfish   268 YTCVVEHQ----RMTIQKSGDEIKSNSSSEV--FITPERVLAILLAALVICLCIC 316

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HLA-BXP_054186779.1 MHC_I 72..246 CDD:395078 56/175 (32%)
IgC1_MHC_Ia_HLA-B 247..343 CDD:409617 30/100 (30%)
Ig strand A 251..259 CDD:409617 1/7 (14%)
Ig strand B 267..276 CDD:409617 3/8 (38%)
Ig strand C 280..286 CDD:409617 2/5 (40%)
Ig strand C' 288..291 CDD:409617 1/2 (50%)
Ig strand D 295..303 CDD:409617 3/7 (43%)
Ig strand E 306..316 CDD:409617 3/9 (33%)
Ig strand F 323..330 CDD:409617 4/8 (50%)
Ig strand G 336..341 CDD:409617 1/4 (25%)
MHC_I_C <389..405 CDD:461964
mhc1ulaNP_001304679.1 MHC_I 16..192 CDD:471794 58/179 (32%)
IgC1_MHC_I_alpha3 197..278 CDD:409495 28/88 (32%)
Ig strand A 197..203 CDD:409495 1/5 (20%)
Ig strand B 208..217 CDD:409495 4/12 (33%)
Ig strand C 222..227 CDD:409495 1/4 (25%)
Ig strand C' 230..233 CDD:409495 1/2 (50%)
Ig strand D 237..245 CDD:409495 3/7 (43%)
Ig strand E 248..258 CDD:409495 3/9 (33%)
Ig strand F 265..274 CDD:409495 4/8 (50%)
Blue background indicates that the domain is not in the aligned region.

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