Protein Alignment HLA-B and H2-T26

DIOPT Version :10

• Sequence 1: XP_054186779.1
• Gene: HLA-B / 3106
• HGNCID: 4932
• Length: 405
• Species: Homo sapiens
• Sequence 2: XP_006524864.1
• Gene: H2-T26 / 667977
• MGIID: 3704134
• Length: 401
• Species: Mus musculus
• Alignment Length: 408
• Identity: 256/408 - (62%)
• Similarity: 298/408 - (73%)
• Gaps: 20/408 - (4%)

Human     5 APRTVLLLLSGALALTETWAGECGVGREMASVGRSEGTAGGGAGPGEPRREEGRAGLSPSSPPGS 69
            ||||:||||:.||.||||.|...|.||.          :|....| .|.....|...:..|.||.
Mouse     2 APRTLLLLLAAALILTETRAATEGPGRR----------SGSHREP-PPGPHSMRYFTTAVSRPGP 55

Human    70 HSMRYFYTAMSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRMAPRAPWIEQEGPEYWDRETQIS 134
            ||||||.||:||||.|||.||:|||||||||||||.||.:|||.|||||:||||||||:|||||:
Mouse    56 HSMRYFETAVSRPGLGEPWFISVGYVDDTQFVRFDGDAENPRMEPRAPWMEQEGPEYWERETQIA 120

Human   135 KTNTQTYRESLRNLRGYYNQSEAGSHTLQRMYGCDVGPDGRLLRGHDQSAYDGKDYIALNEDLSS 199
            |.:.|.::.|||||..|||||..||||.|||||||:|.|||||||:.|.||||.||||||:||.:
Mouse   121 KGHEQGFQGSLRNLLHYYNQSAGGSHTFQRMYGCDLGSDGRLLRGYWQFAYDGSDYIALNQDLKT 185

Human   200 WTAADTAAQITQRKWEAAREAEQWRAYLEGLCVEWLRRYLENGKETLQRADPPKTHVTHHPISDH 264
            |||||.|||||:|:||....||..|||||..|:||||||||.|||||.|.||||.||||||.|:.
Mouse   186 WTAADLAAQITRRRWEQGGVAETLRAYLEDPCLEWLRRYLELGKETLLRTDPPKVHVTHHPRSED 250

Human   265 EATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQ 329
            :.||||||||||||:||||||.:||:.|||.||||||||||.||||||:||||.|:||.|||||.
Mouse   251 DVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQNYTCHVY 315

Human   330 HEGLPKPLTLRWE--PSSQSTIPIVGIVAGLAVLAVVVIGAVVATVMCRRKS-----SGGKGGSY 387
            |||||:|||||||  ||..|.:.|:.::..|.|  |::|||:|..|:..|:.     :|||..:|
Mouse   316 HEGLPEPLTLRWEPRPSRDSNMVIIAVLVVLGV--VIIIGAMVPFVLKSRRKIAFLLTGGKEENY 378

Human   388 SQAASSDSAQGSDVSLTA 405
            :.|..|:|.|||.:.|.|
Mouse   379 ALAGGSNSVQGSALFLEA 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HLA-B	XP_054186779.1	MHC_I	72..246	CDD:395078	127/173 (73%)
		IgC1_MHC_Ia_HLA-B	247..343	CDD:409617	75/97 (77%)
		Ig strand A	251..259	CDD:409617	6/7 (86%)
		Ig strand B	267..276	CDD:409617	8/8 (100%)
		Ig strand C	280..286	CDD:409617	5/5 (100%)
		Ig strand C'	288..291	CDD:409617	2/2 (100%)
		Ig strand D	295..303	CDD:409617	6/7 (86%)
		Ig strand E	306..316	CDD:409617	7/9 (78%)
		Ig strand F	323..330	CDD:409617	5/6 (83%)
		Ig strand G	336..341	CDD:409617	4/4 (100%)
		MHC_I_C	<389..405	CDD:461964	7/15 (47%)
H2-T26	XP_006524864.1	MHC_I	54..232	CDD:395078	130/177 (73%)
		Ig	234..329	CDD:472250	74/94 (79%)
		Ig strand B	252..256	CDD:409353	2/3 (67%)
		Ig strand C	267..271	CDD:409353	3/3 (100%)
		Ig strand E	298..302	CDD:409353	2/3 (67%)
		Ig strand F	309..314	CDD:409353	3/4 (75%)
		Ig strand G	324..327	CDD:409353	2/2 (100%)