Protein Alignment HLA-B and mhc1uba

DIOPT Version :10

• Sequence 1: XP_054186779.1
• Gene: HLA-B / 3106
• HGNCID: 4932
• Length: 405
• Species: Homo sapiens
• Sequence 2: NP_571546.1
• Gene: mhc1uba / 30757
• ZFINID: ZDB-GENE-990415-145
• Length: 348
• Species: Danio rerio
• Alignment Length: 340
• Identity: 106/340 - (31%)
• Similarity: 186/340 - (54%)
• Gaps: 20/340 - (5%)

Human    69 SHSMRYFYTAMSRPGRGE-PRFIAVGYVDDTQFVRFDSDAASPRMAPRAPWIEQE-GPEYWDRET 131
            :||.:.:||..:  |..| |.|:|:..:||.....|||  .:.|...:..|:|.. |.||.:::|
Zfish    20 THSWKAYYTGTT--GLTEFPEFVALNLIDDQLMGYFDS--KTNRFKSQFQWMEDNLGKEYDEQQT 80

Human   132 QISKTNTQTYRESLRNLRGYYNQSEAGSHTLQRMYGCDVGPDGRLLRGHDQSAYDGKDYIALNED 196
            .|.....:.::.:::.:...:||:: |.||.|.||||::..||. .:.|.|..|||:|:|:|::.
Zfish    81 NILLGYPEVFKNNIKVVMERFNQTQ-GVHTFQFMYGCEMDDDGN-KQVHWQIGYDGEDFISLDKK 143

Human   197 LSSWTAADTAAQITQRKWEA-AREAEQWRAYLEGLCVEWLRRYLENGKETLQRADPPKTHVTHHP 260
            ..:||||::.|..|:.||:: ..||..|:.|||..|:||:::|:..||:||:|...|:..:....
Zfish   144 TLTWTAANSQAMTTKVKWDSTGAEANYWKGYLENECIEWVQKYVGYGKDTLERKVSPQVSLLQKS 208

Human   261 ISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGE--EQR 323
            .|   :.:.|...||||:.:.::|||:|:|..:|.||.|..|..|.|:|:.:.:.|...|  :.:
Zfish   209 SS---SPVVCHVTGFYPSGLKISWQRNGQDHDEDVELGELIPNEDGTYQRTSTLNVKPEEWKKDK 270

Human   324 YTCHVQHEGLP-KPLTLRWEPSSQSTIPIVGIVAGLAVLAVVVIGAVVATVMCRRKSSGGKGGSY 387
            ::|.|:|:... ..:....|..:.:...::||:.|:.|.||:::...||..:..|:..|     :
Zfish   271 FSCVVEHQSKTINSILTEDEIRTNNPTALLGIIIGIVVAAVLLVAIAVAGFVVYRRHKG-----F 330

Human   388 SQAASSDSAQGSDVS 402
            .....:.|..|||.|
Zfish   331 KPVPQNTSDGGSDNS 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HLA-B	XP_054186779.1	MHC_I	72..246	CDD:395078	60/176 (34%)
		IgC1_MHC_Ia_HLA-B	247..343	CDD:409617	26/98 (27%)
		Ig strand A	251..259	CDD:409617	1/7 (14%)
		Ig strand B	267..276	CDD:409617	2/8 (25%)
		Ig strand C	280..286	CDD:409617	1/5 (20%)
		Ig strand C'	288..291	CDD:409617	1/2 (50%)
		Ig strand D	295..303	CDD:409617	3/7 (43%)
		Ig strand E	306..316	CDD:409617	2/9 (22%)
		Ig strand F	323..330	CDD:409617	2/6 (33%)
		Ig strand G	336..341	CDD:409617	0/4 (0%)
		MHC_I_C	<389..405	CDD:461964	5/14 (36%)
mhc1uba	NP_571546.1	MHC_I	21..194	CDD:471794	62/178 (35%)
		IgC1_MHC_I_alpha3	198..281	CDD:409495	25/85 (29%)
		Ig strand A	199..206	CDD:409495	1/6 (17%)
		Ig strand B	211..220	CDD:409495	1/8 (13%)
		Ig strand C	225..230	CDD:409495	0/4 (0%)
		Ig strand C'	233..236	CDD:409495	1/2 (50%)
		Ig strand D	240..248	CDD:409495	3/7 (43%)
		Ig strand E	251..261	CDD:409495	2/9 (22%)
		Ig strand F	270..277	CDD:409495	2/6 (33%)