DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HLA-B and RT1-A2

DIOPT Version :10

Sequence 1:XP_054186779.1 Gene:HLA-B / 3106 HGNCID:4932 Length:405 Species:Homo sapiens
Sequence 2:XP_063135035.1 Gene:RT1-A2 / 24974 RGDID:1595923 Length:404 Species:Rattus norvegicus


Alignment Length:402 Identity:239/402 - (59%)
Similarity:282/402 - (70%) Gaps:48/402 - (11%)


- Green bases have known domain annotations that are detailed below.


Human     6 PRTVLLLLSGALALTETWAGECGVGREMASVGRSEGTAGGGAGPGEPRREEGRAGLSPSSPPGSH 70
            |.|:||||:.||..|:|.|                                           |||
  Rat     4 PCTLLLLLAVALTPTQTRA-------------------------------------------GSH 25

Human    71 SMRYFYTAMSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRMAPRAPWIEQEGPEYWDRETQISK 135
            |:|||.||:||||.||||::.|||||||||||:||||.:||..|||||:|:||||||:||||.:|
  Rat    26 SLRYFVTAVSRPGLGEPRYMEVGYVDDTQFVRYDSDAENPRYEPRAPWMEREGPEYWERETQNAK 90

Human   136 TNTQTYRESLRNLRGYYNQSEAGSHTLQRMYGCDVGPDGRLLRGHDQSAYDGKDYIALNEDLSSW 200
            .|.|.||..||....||||||.||||:|||||||:|.||.||||:.|.||||:|||||||||.:|
  Rat    91 RNEQVYRVDLRTALRYYNQSEGGSHTIQRMYGCDMGSDGSLLRGYYQDAYDGRDYIALNEDLKTW 155

Human   201 TAADTAAQITQRKWEAAREAEQWRAYLEGLCVEWLRRYLENGKETLQRADPPKTHVTHHPISDHE 265
            ||||.|||||:.||:.|..||:.||||||.||||||||||.|||||.|:|||:.|||.||..:.:
  Rat   156 TAADFAAQITRSKWDQAGVAERLRAYLEGTCVEWLRRYLELGKETLLRSDPPEAHVTLHPRPEGD 220

Human   266 ATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQH 330
            .||||||||||||:||||||.:|||.|||.||||||||||.||||||:||||.|:||.|||.|:|
  Rat   221 VTLRCWALGFYPADITLTWQLNGEDLTQDMELVETRPAGDGTFQKWASVVVPLGKEQNYTCRVEH 285

Human   331 EGLPKPLTLRWEPS----SQSTIPIVGIVAGLAVLAVVVIGAVVATVMCRRKSSGGKGGSYSQAA 391
            ||||:||:.|||||    |.....::.:|.|..:..:.:||.|||.|..||:::||| |.|:.|.
  Rat   286 EGLPEPLSQRWEPSPSTNSNMETTVIYVVLGAIIGTLAIIGIVVAVVRKRRRNTGGK-GDYTPAP 349

Human   392 SSDSAQGSDVSL 403
            ..||:|.|||||
  Rat   350 GRDSSQSSDVSL 361

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HLA-BXP_054186779.1 MHC_I 72..246 CDD:395078 125/173 (72%)
IgC1_MHC_Ia_HLA-B 247..343 CDD:409617 69/95 (73%)
Ig strand A 251..259 CDD:409617 5/7 (71%)
Ig strand B 267..276 CDD:409617 8/8 (100%)
Ig strand C 280..286 CDD:409617 5/5 (100%)
Ig strand C' 288..291 CDD:409617 2/2 (100%)
Ig strand D 295..303 CDD:409617 6/7 (86%)
Ig strand E 306..316 CDD:409617 7/9 (78%)
Ig strand F 323..330 CDD:409617 4/6 (67%)
Ig strand G 336..341 CDD:409617 2/4 (50%)
MHC_I_C <389..405 CDD:461964 9/15 (60%)
RT1-A2XP_063135035.1 None

Return to query results.
Submit another query.