Protein Alignment HLA-B and H2-T23

DIOPT Version :10

• Sequence 1: XP_054186779.1
• Gene: HLA-B / 3106
• HGNCID: 4932
• Length: 405
• Species: Homo sapiens
• Sequence 2: NP_034528.1
• Gene: H2-T23 / 15040
• MGIID: 95957
• Length: 357
• Species: Mus musculus
• Alignment Length: 338
• Identity: 235/338 - (69%)
• Similarity: 266/338 - (78%)
• Gaps: 6/338 - (1%)

Human    64 SSPPGSHSMRYFYTAMSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRMAPRAPWIEQEGPEYWD 128
            |||   ||:|||.||:||||.||||||.||||||||||||||||.:|||.|||.||||||||||:
Mouse    20 SSP---HSLRYFTTAVSRPGLGEPRFIIVGYVDDTQFVRFDSDAENPRMEPRARWIEQEGPEYWE 81

Human   129 RETQISKTNTQTYRESLRNLRGYYNQSEAGSHTLQRMYGCDVGPDGRLLRGHDQSAYDGKDYIAL 193
            |||..::...:.:|.:||.|.||||||...|||||.|||||||||||||||:.|.||||:|||:|
Mouse    82 RETWKARDMGRNFRVNLRTLLGYYNQSNDESHTLQWMYGCDVGPDGRLLRGYCQEAYDGQDYISL 146

Human   194 NEDLSSWTAADTAAQITQRKWEAAREAEQWRAYLEGLCVEWLRRYLENGKETLQRADPPKTHVTH 258
            ||||.||||.|.|:||::.|.||..||.|.||||:|.|||||.|||..|.|||||:||||.||||
Mouse   147 NEDLRSWTANDIASQISKHKSEAVDEAHQQRAYLQGPCVEWLHRYLRLGNETLQRSDPPKAHVTH 211

Human   259 HPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQR 323
            ||.|:.|.||||||||||||:||||||.:||:.|||.||||||||||.|||||||||||.|:||.
Mouse   212 HPRSEDEVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWAAVVVPLGKEQY 276

Human   324 YTCHVQHEGLPKPLTLRWEPSSQSTIPIVGIVAGLAVL-AVVVIGAVVATVMCRRKSSGGKGGSY 387
            |||||.|||||:|||||||| ..||:..:.|:|.|.|| ||:::|||||.||.||:..|.| |.|
Mouse   277 YTCHVYHEGLPEPLTLRWEP-PPSTVSNMVIIAVLVVLGAVIILGAVVAFVMKRRRHIGVK-GCY 339

Human   388 SQAASSDSAQGSD 400
            :....|.|.|.||
Mouse   340 AHVLGSKSFQTSD 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HLA-B	XP_054186779.1	MHC_I	72..246	CDD:395078	122/173 (71%)
		IgC1_MHC_Ia_HLA-B	247..343	CDD:409617	77/95 (81%)
		Ig strand A	251..259	CDD:409617	6/7 (86%)
		Ig strand B	267..276	CDD:409617	8/8 (100%)
		Ig strand C	280..286	CDD:409617	5/5 (100%)
		Ig strand C'	288..291	CDD:409617	2/2 (100%)
		Ig strand D	295..303	CDD:409617	6/7 (86%)
		Ig strand E	306..316	CDD:409617	8/9 (89%)
		Ig strand F	323..330	CDD:409617	5/6 (83%)
		Ig strand G	336..341	CDD:409617	4/4 (100%)
		MHC_I_C	<389..405	CDD:461964	5/12 (42%)
H2-T23	NP_034528.1	Alpha-1	21..110		64/91 (70%)
		MHC_I	22..199	CDD:395078	125/179 (70%)
		Alpha-2	111..202		65/90 (72%)
		IgC1_MHC_1b_Qa-1b	200..297	CDD:409625	79/97 (81%)
		Alpha-3	203..294		73/90 (81%)
		Ig strand A	204..213	CDD:409625	7/8 (88%)
		Ig strand B	218..228	CDD:409625	8/9 (89%)
		Ig strand C	233..239	CDD:409625	5/5 (100%)
		Ig strand C'	241..244	CDD:409625	2/2 (100%)
		Ig strand D	248..256	CDD:409625	6/7 (86%)
		Ig strand E	259..269	CDD:409625	8/9 (89%)
		Ig strand F	276..283	CDD:409625	5/6 (83%)
		Ig strand G	290..293	CDD:409625	2/2 (100%)
		Connecting peptide	295..304		4/9 (44%)
		TM_EGFR-like	296..333	CDD:213052	19/37 (51%)