Protein Alignment HLA-B and H2-Q7

DIOPT Version :10

• Sequence 1: XP_054186779.1
• Gene: HLA-B / 3106
• HGNCID: 4932
• Length: 405
• Species: Homo sapiens
• Sequence 2: NP_034524.3
• Gene: H2-Q7 / 15018
• MGIID: 95936
• Length: 334
• Species: Mus musculus
• Alignment Length: 374
• Identity: 226/374 - (60%)
• Similarity: 266/374 - (71%)
• Gaps: 50/374 - (13%)

Human     9 VLLLLSGALALTETWAGECGVGREMASVGRSEGTAGGGAGPGEPRREEGRAGLSPSSPPGSHSMR 73
            :|||::.||.|.||.||:                                           ||::
Mouse     6 LLLLVAAALTLIETRAGQ-------------------------------------------HSLQ 27

Human    74 YFYTAMSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRMAPRAPWIEQEGPEYWDRETQISKTNT 138
            ||:||:||||.|||.||:||||||||||||||||.:|||.|||.|:||||||||:|||||:|.:.
Mouse    28 YFHTAVSRPGLGEPWFISVGYVDDTQFVRFDSDAENPRMEPRARWMEQEGPEYWERETQIAKGHE 92

Human   139 QTYRESLRNLRGYYNQSEAGSHTLQRMYGCDVGPDGRLLRGHDQSAYDGKDYIALNEDLSSWTAA 203
            |::|.|||..:.|||||:.||||||.|||||:|.|||||||:.|.||:|:|||||||||.:|||.
Mouse    93 QSFRGSLRTAQSYYNQSKGGSHTLQWMYGCDMGSDGRLLRGYLQFAYEGRDYIALNEDLKTWTAV 157

Human   204 DTAAQITQRKWEAAREAEQWRAYLEGLCVEWLRRYLENGKETLQRADPPKTHVTHHPISDHEATL 268
            |.|||||:||||.|..||:.:|||||.|::.|||||:.|||||.|.||||.||||||.|....||
Mouse   158 DMAAQITRRKWEQAGIAEKDQAYLEGTCMQSLRRYLQLGKETLLRTDPPKAHVTHHPRSYGAVTL 222

Human   269 RCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGL 333
            ||||||||||:||||||.:||:.|||.||||||||||.||||||:||||.|:||.|||||.||||
Mouse   223 RCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQNYTCHVNHEGL 287

Human   334 PKPLTLRW-----EPSSQSTIPIVGIVAGLAVLAVVVIGAVVATVMCRR 377
            |:||||||     .|.:.|.:..:.:|..|.  ||.:||||||.||.||
Mouse   288 PEPLTLRWGRWEPPPYTVSNMATIAVVVDLG--AVAIIGAVVAFVMNRR 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HLA-B	XP_054186779.1	MHC_I	72..246	CDD:395078	122/173 (71%)
		IgC1_MHC_Ia_HLA-B	247..343	CDD:409617	74/100 (74%)
		Ig strand A	251..259	CDD:409617	6/7 (86%)
		Ig strand B	267..276	CDD:409617	8/8 (100%)
		Ig strand C	280..286	CDD:409617	5/5 (100%)
		Ig strand C'	288..291	CDD:409617	2/2 (100%)
		Ig strand D	295..303	CDD:409617	6/7 (86%)
		Ig strand E	306..316	CDD:409617	7/9 (78%)
		Ig strand F	323..330	CDD:409617	5/6 (83%)
		Ig strand G	336..341	CDD:409617	4/4 (100%)
		MHC_I_C	<389..405	CDD:461964
H2-Q7	NP_034524.3	MHC_I	22..200	CDD:395078	125/220 (57%)
		Alpha-1	22..111		63/131 (48%)
		Alpha-2	112..203		64/90 (71%)
		IgC1_MHC_Ib_Qa-2	203..295	CDD:409605	71/91 (78%)
		Alpha-3	204..295		71/90 (79%)
		Ig strand A	205..213	CDD:409605	6/7 (86%)
		Ig strand B	221..230	CDD:409605	8/8 (100%)
		Ig strand C	234..240	CDD:409605	5/5 (100%)
		Ig strand C'	242..245	CDD:409605	2/2 (100%)
		Ig strand D	249..257	CDD:409605	6/7 (86%)
		Ig strand E	260..270	CDD:409605	7/9 (78%)
		Ig strand F	277..284	CDD:409605	5/6 (83%)
		Ig strand G	291..294	CDD:409605	2/2 (100%)
		Connecting peptide	296..310		2/13 (15%)