DRSC/TRiP Functional Genomics Resources

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Protein Alignment HLA-B and H2-Q4

DIOPT Version :10

Sequence 1:XP_054186779.1 Gene:HLA-B / 3106 HGNCID:4932 Length:405 Species:Homo sapiens
Sequence 2:NP_001137161.1 Gene:H2-Q4 / 15015 MGIID:95933 Length:354 Species:Mus musculus


Alignment Length:361 Identity:225/361 - (62%)
Similarity:264/361 - (73%) Gaps:20/361 - (5%)


- Green bases have known domain annotations that are detailed below.


Human     8 TVLLLLSGALALTETWAGECGVGREMASVGRSEGTAGGGAGPGEPRREEGRAGLSPSSPPGSHSM 72
            |:||||   :|:.:|........|......||  .||   |||.      .:|...:.|||.|.:
Mouse     4 TMLLLL---VAVAQTLIEIRAAPRPAPLPARS--PAG---GPGR------SSGSHRALPPGPHLL 54

Human    73 RYFYTAMSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRMAPRAPWIEQEGPEYWDRETQISKTN 137
            .||||::||||.||||||:|||||:|:||||||||.:||..|||||:||||||||:||||.:|.|
Mouse    55 SYFYTSVSRPGLGEPRFISVGYVDNTEFVRFDSDAENPRYEPRAPWMEQEGPEYWERETQKAKGN 119

Human   138 TQTYRESLRNLRGYYNQSEAGSHTLQRMYGCDVGPDGRLLRGHDQSAYDGKDYIALNEDLSSWTA 202
            .|.:|.:||.|..|||||..||||:|.:.||:||.|||||||:.|.||||:|||||||||.:|||
Mouse   120 EQIFRVNLRTLLSYYNQSAGGSHTIQVISGCEVGSDGRLLRGYQQFAYDGRDYIALNEDLKTWTA 184

Human   203 ADTAAQITQRKWEAAREAEQWRAYLEGLCVEWLRRYLENGKETLQRADPPKTHVTHHPISDHEAT 267
            ||.|||||:||||.|...|:.:|||||.||:.||||||.|||||.|.||||.|||.|..||.:.|
Mouse   185 ADMAAQITRRKWEQAGATEKSKAYLEGACVQSLRRYLELGKETLLRTDPPKAHVTCHHRSDGDVT 249

Human   268 LRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEG 332
            |||||||||||.|.||||.:||:.|||.|||||||:||.||||||:||||.|:||.|||||.|||
Mouse   250 LRCWALGFYPANIILTWQLNGEELTQDMELVETRPSGDGTFQKWASVVVPLGKEQNYTCHVHHEG 314

Human   333 LPKPLTLRWEPSSQSTIPIVGIVAGLAVLAVVVIGA 368
            ||:||||||||...:    |..:|.:|||  ||:||
Mouse   315 LPEPLTLRWEPPPST----VSNMANVAVL--VVLGA 344

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HLA-BXP_054186779.1 MHC_I 72..246 CDD:395078 121/173 (70%)
IgC1_MHC_Ia_HLA-B 247..343 CDD:409617 71/95 (75%)
Ig strand A 251..259 CDD:409617 6/7 (86%)
Ig strand B 267..276 CDD:409617 8/8 (100%)
Ig strand C 280..286 CDD:409617 4/5 (80%)
Ig strand C' 288..291 CDD:409617 2/2 (100%)
Ig strand D 295..303 CDD:409617 6/7 (86%)
Ig strand E 306..316 CDD:409617 7/9 (78%)
Ig strand F 323..330 CDD:409617 5/6 (83%)
Ig strand G 336..341 CDD:409617 4/4 (100%)
MHC_I_C <389..405 CDD:461964
H2-Q4NP_001137161.1 MHC_I 50..228 CDD:395078 123/177 (69%)
Ig 230..326 CDD:472250 72/95 (76%)
Ig strand B 248..252 CDD:409625 2/3 (67%)
Ig strand C 263..267 CDD:409625 2/3 (67%)
Ig strand E 294..298 CDD:409625 2/3 (67%)
Ig strand F 305..310 CDD:409625 3/4 (75%)
Ig strand G 320..323 CDD:409625 2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

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