Protein Alignment HLA-B and H2-Q2

DIOPT Version :10

• Sequence 1: XP_054186779.1
• Gene: HLA-B / 3106
• HGNCID: 4932
• Length: 405
• Species: Homo sapiens
• Sequence 2: NP_034522.2
• Gene: H2-Q2 / 15013
• MGIID: 95931
• Length: 360
• Species: Mus musculus
• Alignment Length: 400
• Identity: 246/400 - (61%)
• Similarity: 283/400 - (70%)
• Gaps: 45/400 - (11%)

Human     5 APRTVLLLLSGALALTETWAGECGVGREMASVGRSEGTAGGGAGPGEPRREEGRAGLSPSSPPGS 69
            |.|.:||||..||.||||.|                                           ||
Mouse     2 ALRRLLLLLVAALKLTETRA-------------------------------------------GS 23

Human    70 HSMRYFYTAMSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRMAPRAPWIEQEGPEYWDRETQIS 134
            ||:|||.||:||||.||||||.||||||||||||||||.:|||.|||||:||||||||:|.||:|
Mouse    24 HSLRYFTTAVSRPGLGEPRFIIVGYVDDTQFVRFDSDAENPRMEPRAPWMEQEGPEYWERNTQVS 88

Human   135 KTNTQTYRESLRNLRGYYNQSEAGSHTLQRMYGCDVGPDGRLLRGHDQSAYDGKDYIALNEDLSS 199
            |.|.|::|.||.....|||||:.||||||.:.|||:||||.||||::||||||:||:||||||.:
Mouse    89 KENEQSFRVSLGTALSYYNQSKGGSHTLQWLVGCDLGPDGSLLRGYEQSAYDGRDYLALNEDLIT 153

Human   200 WTAADTAAQITQRKWEAAREAEQWRAYLEGLCVEWLRRYLENGKETLQRADPPKTHVTHHPISDH 264
            |||||.||..|:.|.|.|..||:.|||||..|:.|||||||.|||||...||||.||||||.|..
Mouse   154 WTAADLAALKTRSKLEQAGLAEKRRAYLEVDCLTWLRRYLELGKETLLHTDPPKAHVTHHPSSQG 218

Human   265 EATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQ 329
            :.||||||||||||:||||||.:|||.|||.|||||||:||.||||||:|:||.|||.||||||:
Mouse   219 DVTLRCWALGFYPADITLTWQLNGEDLTQDMELVETRPSGDGTFQKWASVMVPFGEEPRYTCHVE 283

Human   330 HEGLPKPLTLRWEPSSQSTIPIVGIVAGLAVL-AVVVIGAVVATVMCRRKSSGGKGGSYSQAASS 393
            |||||:|||||||| ..||...:.|:|.|.|| ||::||||||.||.|.:::|||...|:|....
Mouse   284 HEGLPEPLTLRWEP-PPSTDSYMVIIAVLVVLGAVIIIGAVVAFVMKRGRNTGGKVRDYAQDPGR 347

Human   394 DSAQGSDVSL 403
            ||.|.||:||
Mouse   348 DSPQSSDISL 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HLA-B	XP_054186779.1	MHC_I	72..246	CDD:395078	122/173 (71%)
		IgC1_MHC_Ia_HLA-B	247..343	CDD:409617	73/95 (77%)
		Ig strand A	251..259	CDD:409617	6/7 (86%)
		Ig strand B	267..276	CDD:409617	8/8 (100%)
		Ig strand C	280..286	CDD:409617	5/5 (100%)
		Ig strand C'	288..291	CDD:409617	2/2 (100%)
		Ig strand D	295..303	CDD:409617	6/7 (86%)
		Ig strand E	306..316	CDD:409617	7/9 (78%)
		Ig strand F	323..330	CDD:409617	6/6 (100%)
		Ig strand G	336..341	CDD:409617	4/4 (100%)
		MHC_I_C	<389..405	CDD:461964	7/14 (50%)
H2-Q2	NP_034522.2	MHC_I	22..200	CDD:395078	126/177 (71%)
		IgC1_MHC_I_alpha3	204..295	CDD:409495	71/90 (79%)
		Ig strand A	205..212	CDD:409495	5/6 (83%)
		Ig strand B	220..229	CDD:409495	7/8 (88%)
		Ig strand C	234..239	CDD:409495	4/4 (100%)
		Ig strand C'	242..245	CDD:409495	2/2 (100%)
		Ig strand D	249..257	CDD:409495	6/7 (86%)
		Ig strand E	260..270	CDD:409495	7/9 (78%)
		Ig strand F	277..284	CDD:409495	6/6 (100%)
		Ig strand G	291..294	CDD:409495	2/2 (100%)
		MHC_I_C	334..357	CDD:461964	10/22 (45%)