DRSC/TRiP Functional Genomics Resources

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Protein Alignment HLA-B and H2-Q10

DIOPT Version :10

Sequence 1:XP_054186779.1 Gene:HLA-B / 3106 HGNCID:4932 Length:405 Species:Homo sapiens
Sequence 2:NP_034521.1 Gene:H2-Q10 / 15007 MGIID:95929 Length:325 Species:Mus musculus


Alignment Length:358 Identity:232/358 - (64%)
Similarity:260/358 - (72%) Gaps:44/358 - (12%)


- Green bases have known domain annotations that are detailed below.


Human     1 MRVTAPRTVLLLLSGALALTETWAGECGVGREMASVGRSEGTAGGGAGPGEPRREEGRAGLSPSS 65
            |...||||:||||:.|||.|:|.|                                         
Mouse     1 MGAMAPRTLLLLLAAALAPTQTQA----------------------------------------- 24

Human    66 PPGSHSMRYFYTAMSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRMAPRAPWIEQEGPEYWDRE 130
              ||||||||.|::||||.||||||.||||||||||||||||.:|||.|||||:||||||||:||
Mouse    25 --GSHSMRYFETSVSRPGLGEPRFIIVGYVDDTQFVRFDSDAETPRMEPRAPWMEQEGPEYWERE 87

Human   131 TQISKTNTQTYRESLRNLRGYYNQSEAGSHTLQRMYGCDVGPDGRLLRGHDQSAYDGKDYIALNE 195
            ||.:|.|.|::..|||.|.|||||||:||||:|.||||.||.|||.|||:.|.||||:|||||||
Mouse    88 TQRAKGNEQSFHVSLRTLLGYYNQSESGSHTIQWMYGCKVGSDGRFLRGYLQYAYDGRDYIALNE 152

Human   196 DLSSWTAADTAAQITQRKWEAAREAEQWRAYLEGLCVEWLRRYLENGKETLQRADPPKTHVTHHP 260
            ||.:|||||.||.||:||||.|..||.:|||||..|||||.||||.|||||.|.|||||||||||
Mouse   153 DLKTWTAADVAAIITRRKWEQAGAAEYYRAYLEAECVEWLLRYLELGKETLLRTDPPKTHVTHHP 217

Human   261 ISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYT 325
            .|:.:.||||||||||||:||||||.:||:.|||.||||||||||.||||||:||||.|:||.||
Mouse   218 GSEGDVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQNYT 282

Human   326 CHVQHEGLPKPLTLRWEPSSQSTIPIVGIVAGL 358
            |||.|||||:|||||||| ..||..|:..:|.|
Mouse   283 CHVYHEGLPEPLTLRWEP-PPSTDSIMSHIADL 314

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HLA-BXP_054186779.1 MHC_I 72..246 CDD:395078 129/173 (75%)
IgC1_MHC_Ia_HLA-B 247..343 CDD:409617 75/95 (79%)
Ig strand A 251..259 CDD:409617 7/7 (100%)
Ig strand B 267..276 CDD:409617 8/8 (100%)
Ig strand C 280..286 CDD:409617 5/5 (100%)
Ig strand C' 288..291 CDD:409617 2/2 (100%)
Ig strand D 295..303 CDD:409617 6/7 (86%)
Ig strand E 306..316 CDD:409617 7/9 (78%)
Ig strand F 323..330 CDD:409617 5/6 (83%)
Ig strand G 336..341 CDD:409617 4/4 (100%)
MHC_I_C <389..405 CDD:461964
H2-Q10NP_034521.1 MHC_I 25..203 CDD:395078 133/177 (75%)
Alpha-1 25..114 68/88 (77%)
Alpha-2 115..206 66/90 (73%)
Ig 205..301 CDD:472250 77/96 (80%)
Alpha-3 207..298 72/90 (80%)
Ig strand B 223..227 CDD:409353 2/3 (67%)
Ig strand C 238..242 CDD:409353 3/3 (100%)
Ig strand E 269..273 CDD:409353 2/3 (67%)
Ig strand F 280..285 CDD:409353 3/4 (75%)
Ig strand G 295..298 CDD:409353 2/2 (100%)
Connecting peptide 299..310 5/11 (45%)
Blue background indicates that the domain is not in the aligned region.

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