Protein Alignment HLA-B and H2-K1

DIOPT Version :10

• Sequence 1: XP_054186779.1
• Gene: HLA-B / 3106
• HGNCID: 4932
• Length: 405
• Species: Homo sapiens
• Sequence 2: XP_006523736.1
• Gene: H2-K1 / 14972
• MGIID: 95904
• Length: 458
• Species: Mus musculus
• Alignment Length: 390
• Identity: 240/390 - (61%)
• Similarity: 282/390 - (72%)
• Gaps: 26/390 - (6%)

Human     6 PRTVLLLLSGALALTETWAGECGVGREMASVGRSEGTAGGGAGPGEPRREEGRAGLSPSSPPGSH 70
            |.|:||||:.|||.|:|                   .|...|..|..|    .:|...:.|||.|
Mouse     3 PCTLLLLLAAALAPTQT-------------------RAARAAARGLVR----WSGSHRAPPPGPH 44

Human    71 SMRYFYTAMSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRMAPRAPWIEQEGPEYWDRETQISK 135
            |:|||.||:||||.||||::.|||||||:||||||||.:||..|||.|:||||||||:||||.:|
Mouse    45 SLRYFVTAVSRPGLGEPRYMEVGYVDDTEFVRFDSDAENPRYEPRARWMEQEGPEYWERETQKAK 109

Human   136 TNTQTYRESLRNLRGYYNQSEAGSHTLQRMYGCDVGPDGRLLRGHDQSAYDGKDYIALNEDLSSW 200
            .|.|::|..||.|.||||||:.||||:|.:.||:||.|||||||:.|.||||.|||||||||.:|
Mouse   110 GNEQSFRVDLRTLLGYYNQSKGGSHTIQVISGCEVGSDGRLLRGYQQYAYDGCDYIALNEDLKTW 174

Human   201 TAADTAAQITQRKWEAAREAEQWRAYLEGLCVEWLRRYLENGKETLQRADPPKTHVTHHPISDHE 265
            ||||.||.||:.|||.|.|||:.||||||.|||||||||:||..||.|.|.||.|||||...:.:
Mouse   175 TAADMAALITKHKWEQAGEAERLRAYLEGTCVEWLRRYLKNGNATLLRTDSPKAHVTHHSRPEDK 239

Human   266 ATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQH 330
            .||||||||||||:||||||.:||:..||.||||||||||.||||||:||||.|:||.|||||.|
Mouse   240 VTLRCWALGFYPADITLTWQLNGEELIQDMELVETRPAGDGTFQKWASVVVPLGKEQYYTCHVYH 304

Human   331 EGLPKPLTLRWEPSSQSTIPIVGIVAGLAVL-AVVVIGAVVATVM-CRRKSSGGKGGSYSQAASS 393
            :|||:|||||||| ..||:..:..||.|.|| |.:|.|||||.|| .||:::|.||.|.|..::|
Mouse   305 QGLPEPLTLRWEP-PPSTVSNMATVAVLVVLGAAIVTGAVVAFVMKMRRRNTGRKGQSLSFLSAS 368

Human   394  393
            Mouse   369  368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HLA-B	XP_054186779.1	MHC_I	72..246	CDD:395078	122/173 (71%)
		IgC1_MHC_Ia_HLA-B	247..343	CDD:409617	69/95 (73%)
		Ig strand A	251..259	CDD:409617	5/7 (71%)
		Ig strand B	267..276	CDD:409617	8/8 (100%)
		Ig strand C	280..286	CDD:409617	5/5 (100%)
		Ig strand C'	288..291	CDD:409617	2/2 (100%)
		Ig strand D	295..303	CDD:409617	6/7 (86%)
		Ig strand E	306..316	CDD:409617	7/9 (78%)
		Ig strand F	323..330	CDD:409617	5/6 (83%)
		Ig strand G	336..341	CDD:409617	4/4 (100%)
		MHC_I_C	<389..405	CDD:461964	1/5 (20%)
H2-K1	XP_006523736.1	MHC_I	42..220	CDD:395078	125/177 (71%)
		IgC1_MHC_Ia_H-2Kb	222..315	CDD:409610	67/92 (73%)
		Ig strand A	225..233	CDD:409610	5/7 (71%)
		Ig strand B	241..250	CDD:409610	8/8 (100%)
		Ig strand C	254..260	CDD:409610	5/5 (100%)
		Ig strand C'	262..265	CDD:409610	2/2 (100%)
		Ig strand D	269..277	CDD:409610	6/7 (86%)
		Ig strand E	280..290	CDD:409610	7/9 (78%)
		Ig strand F	298..304	CDD:409610	5/5 (100%)
		Ig strand G	311..314	CDD:409610	2/2 (100%)