Protein Alignment HLA-B and H2-D1

DIOPT Version :10

• Sequence 1: XP_054186779.1
• Gene: HLA-B / 3106
• HGNCID: 4932
• Length: 405
• Species: Homo sapiens
• Sequence 2: NP_034510.3
• Gene: H2-D1 / 14964
• MGIID: 95896
• Length: 362
• Species: Mus musculus
• Alignment Length: 404
• Identity: 247/404 - (61%)
• Similarity: 286/404 - (70%)
• Gaps: 48/404 - (11%)

Human     1 MRVTAPRTVLLLLSGALALTETWAGECGVGREMASVGRSEGTAGGGAGPGEPRREEGRAGLSPSS 65
            |...||||:||||:.|||.|:|.|
Mouse     1 MGAMAPRTLLLLLAAALAPTQTRA----------------------------------------- 24

Human    66 PPGSHSMRYFYTAMSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRMAPRAPWIEQEGPEYWDRE 130
              |.||||||.||:||||..|||:|:|||||:.:||||||||.:||..|||||:||||||||:||
Mouse    25 --GPHSMRYFETAVSRPGLEEPRYISVGYVDNKEFVRFDSDAENPRYEPRAPWMEQEGPEYWERE 87

Human   131 TQISKTNTQTYRESLRNLRGYYNQSEAGSHTLQRMYGCDVGPDGRLLRGHDQSAYDGKDYIALNE 195
            ||.:|...|.:|.|||||.||||||..||||||:|.|||:|.|.|||||:.|.||:|:|||||||
Mouse    88 TQKAKGQEQWFRVSLRNLLGYYNQSAGGSHTLQQMSGCDLGSDWRLLRGYLQFAYEGRDYIALNE 152

Human   196 DLSSWTAADTAAQITQRKWEAAREAEQWRAYLEGLCVEWLRRYLENGKETLQRADPPKTHVTHHP 260
            ||.:|||||.|||||:||||.:..||.::|||||.|||||.|||:||..||.|.|.||.||||||
Mouse   153 DLKTWTAADMAAQITRRKWEQSGAAEHYKAYLEGECVEWLHRYLKNGNATLLRTDSPKAHVTHHP 217

Human   261 ISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYT 325
            .|..|.||||||||||||:||||||.:||:.|||.||||||||||.||||||:||||.|:||.||
Mouse   218 RSKGEVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQNYT 282

Human   326 CHVQHEGLPKPLTLRWEPSSQSTIPIVGIVAGLAVL-AVVVIGAVVATVMCRRKSSGGKGGSYSQ 389
            |.|.|||||:|||||||| ..||...:.|||.|.|| |:.:||||||.||.||:::|||||.|:.
Mouse   283 CRVYHEGLPEPLTLRWEP-PPSTDSYMVIVAVLGVLGAMAIIGAVVAFVMKRRRNTGGKGGDYAL 346

Human   390 AASSDSAQGSDVSL 403
            |..|   |.|::||
Mouse   347 APGS---QSSEMSL 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HLA-B	XP_054186779.1	MHC_I	72..246	CDD:395078	121/173 (70%)
		IgC1_MHC_Ia_HLA-B	247..343	CDD:409617	73/95 (77%)
		Ig strand A	251..259	CDD:409617	5/7 (71%)
		Ig strand B	267..276	CDD:409617	8/8 (100%)
		Ig strand C	280..286	CDD:409617	5/5 (100%)
		Ig strand C'	288..291	CDD:409617	2/2 (100%)
		Ig strand D	295..303	CDD:409617	6/7 (86%)
		Ig strand E	306..316	CDD:409617	7/9 (78%)
		Ig strand F	323..330	CDD:409617	4/6 (67%)
		Ig strand G	336..341	CDD:409617	4/4 (100%)
		MHC_I_C	<389..405	CDD:461964	6/15 (40%)
H2-D1	NP_034510.3	MHC_I	25..203	CDD:395078	124/177 (70%)
		Alpha-1	25..114		63/88 (72%)
		Alpha-2	115..206		63/90 (70%)
		IgC1_MHC_Ia_H2Db_H2Ld	204..298	CDD:409609	71/93 (76%)
		Alpha-3	207..298		70/90 (78%)
		Ig strand A	208..216	CDD:409609	5/7 (71%)
		Ig strand B	224..232	CDD:409609	7/7 (100%)
		Ig strand C	237..243	CDD:409609	5/5 (100%)
		Ig strand C'	245..248	CDD:409609	2/2 (100%)
		Ig strand D	252..260	CDD:409609	6/7 (86%)
		Ig strand E	263..273	CDD:409609	7/9 (78%)
		Ig strand F	280..287	CDD:409609	4/6 (67%)
		Ig strand G	293..297	CDD:409609	3/3 (100%)
		Connecting peptide	299..309		4/10 (40%)
		TM_EGFR-like	300..336	CDD:213052	20/36 (56%)
		MHC_I_C	337..361	CDD:461964	12/24 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	340..362		10/21 (48%)