DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HLA-B and H2-Q6

DIOPT Version :10

Sequence 1:XP_054186779.1 Gene:HLA-B / 3106 HGNCID:4932 Length:405 Species:Homo sapiens
Sequence 2:NP_997531.1 Gene:H2-Q6 / 110557 MGIID:95935 Length:326 Species:Mus musculus


Alignment Length:358 Identity:215/358 - (60%)
Similarity:250/358 - (69%) Gaps:47/358 - (13%)


- Green bases have known domain annotations that are detailed below.


Human     8 TVLLLLSGALALTETWAGECGVGREMASVGRSEGTAGGGAGPGEPRREEGRAGLSPSSPPGSHSM 72
            |:|||::.||.|.||.|                                           |.||:
Mouse     5 TLLLLVAAALTLIETRA-------------------------------------------GPHSL 26

Human    73 RYFYTAMSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRMAPRAPWIEQEGPEYWDRETQISKTN 137
            |||:||:|.||..|||||.|||||:.|||||||||.:|||.|||.|:||||||||:||||.:|.:
Mouse    27 RYFHTAVSWPGLVEPRFIIVGYVDNKQFVRFDSDAENPRMEPRARWMEQEGPEYWERETQKAKGH 91

Human   138 TQTYRESLRNLRGYYNQSEAGSHTLQRMYGCDVGPDGRLLRGHDQSAYDGKDYIALNEDLSSWTA 202
            .:::|.|||..:.|||||:.||||||.|||||||.|.|||||:.|.||:|:|||||||||.:|||
Mouse    92 EESFRVSLRTAQRYYNQSKGGSHTLQWMYGCDVGSDERLLRGYLQFAYEGRDYIALNEDLKTWTA 156

Human   203 ADTAAQITQRKWEAAREAEQWRAYLEGLCVEWLRRYLENGKETLQRADPPKTHVTHHPISDHEAT 267
            ||.|||||..|||.|..||:.||||||.||:.|||||:..||||...||||.||||||.|....|
Mouse   157 ADMAAQITLHKWEQAGIAERDRAYLEGACVQSLRRYLQLRKETLLCTDPPKAHVTHHPRSYGAVT 221

Human   268 LRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEG 332
            |||||||||||:||||||.:||:.|||.||||||||||.||||||:||||.|:||.|||||.|||
Mouse   222 LRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQNYTCHVNHEG 286

Human   333 LPKPLTLRWEPSSQSTIPIVGIVAGLAVLAVVV 365
            ||:||||||||...:    |..:|.:|:|.|:|
Mouse   287 LPEPLTLRWEPPPST----VSNMANVAILVVLV 315

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HLA-BXP_054186779.1 MHC_I 72..246 CDD:395078 119/173 (69%)
IgC1_MHC_Ia_HLA-B 247..343 CDD:409617 73/95 (77%)
Ig strand A 251..259 CDD:409617 6/7 (86%)
Ig strand B 267..276 CDD:409617 8/8 (100%)
Ig strand C 280..286 CDD:409617 5/5 (100%)
Ig strand C' 288..291 CDD:409617 2/2 (100%)
Ig strand D 295..303 CDD:409617 6/7 (86%)
Ig strand E 306..316 CDD:409617 7/9 (78%)
Ig strand F 323..330 CDD:409617 5/6 (83%)
Ig strand G 336..341 CDD:409617 4/4 (100%)
MHC_I_C <389..405 CDD:461964
H2-Q6NP_997531.1 MHC_I 22..200 CDD:395078 122/177 (69%)
IgC1_MHC_Ib_Qa-2 202..295 CDD:409605 71/92 (77%)
Ig strand A 205..213 CDD:409605 6/7 (86%)
Ig strand B 221..230 CDD:409605 8/8 (100%)
Ig strand C 234..240 CDD:409605 5/5 (100%)
Ig strand C' 242..245 CDD:409605 2/2 (100%)
Ig strand D 249..257 CDD:409605 6/7 (86%)
Ig strand E 260..270 CDD:409605 7/9 (78%)
Ig strand F 277..284 CDD:409605 5/6 (83%)
Ig strand G 291..294 CDD:409605 2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.