DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4E7 and eif4eb

DIOPT Version :9

Sequence 1:	NP_726718.1	Gene:	eIF4E7 / 31059	FlyBaseID:	FBgn0040368	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_001007778.1	Gene:	eif4eb / 493617	ZFINID:	ZDB-GENE-041121-14	Length:	216	Species:	Danio rerio

Alignment Length:	236	Identity:	105/236 - (44%)
Similarity:	139/236 - (58%)	Gaps:	27/236 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 EPRIKQNTCPPAKKEDAVVAFDNSLEFLSLNNKCDDDLTIAAENAELLEVED-PQHPLNNCWTLW 260
            ||.||.|:|   |.|:.:                .|:     .|.|::..|. .:|||.|.|.||
Zfish     5 EPEIKSNSC---KSEEEI----------------SDE-----SNQEIVSPESYIKHPLQNRWCLW 45

  Fly   261 YLENDRNKSWEEMLHKVTSFDTVEKFWSLITHIKPPSELMLGSDYSLFKKGIRPMWEDEANVNGG 325
            :.:||::|:|:..|..::.|||||.||:|..||:..|.||.|.||||||.||.||||||.|..||
Zfish    46 FFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMSGCDYSLFKDGIEPMWEDERNKRGG 110

  Fly   326 RWVINLTK-SAKMALDSFWMDAMLCLIGEAC-KHSDDLCGVVVNIRGKSNKISIWNADGGNQTTV 388
            ||:|.|.| ..|..||.||::.:|||||||. .:|||:||.|||:|.|.:||:||.||.||:..|
Zfish   111 RWLITLNKQQRKYDLDRFWLETLLCLIGEAFDDYSDDVCGAVVNVRTKGDKIAIWTADYGNREAV 175

  Fly   389 LEIGRILRKVLRMDNIYVLEYQLHKDSKDKLGSTVKRIYTV 429
            ..|||:.::.|.:.....:.||.|.|:..|.|||.|..:.|
Zfish   176 THIGRVYKERLGVPMNMTIGYQSHADTATKSGSTTKNKFVV 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4E7	NP_726718.1	IF4E	255..409	CDD:279921	80/155 (52%)
eif4eb	NP_001007778.1	IF4E	40..196	CDD:279921	80/155 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573562
Domainoid	1	1.000	193	1.000	Domainoid score	I3137
eggNOG	1	0.900	-	-		E1_COG5053
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123817
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3585
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1394271at2759
OrthoFinder	1	1.000	-	-		FOG0000666
OrthoInspector	1	1.000	-	-		mtm6577
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11960
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R595
SonicParanoid	1	1.000	-	-		X406
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.890