DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4E7 and EIF4E

DIOPT Version :9

Sequence 1:	NP_726718.1	Gene:	eIF4E7 / 31059	FlyBaseID:	FBgn0040368	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_001124151.1	Gene:	EIF4E / 1977	HGNCID:	3287	Length:	248	Species:	Homo sapiens

Alignment Length:	222	Identity:	92/222 - (41%)
Similarity:	125/222 - (56%)	Gaps:	37/222 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 EVEDPQ----HPLNNCWTLWYLENDRNKSWEEMLHKVTSFDTVEKFWSLITHIKPPSELMLGSDY 305
            ||.:|:    |||.|.|.||:.:||::|:|:..|..::.|||||.||:|..||:..|.||.|.||
Human    27 EVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDY 91

  Fly   306 SLFKKGIRPMWEDEANVNGGRWVINLTKSAKMA-LDSFWMDA----------------------- 346
            ||||.||.||||||.|..||||:|.|.|..:.: ||.||::.
Human    92 SLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETRWDLAMLPRLVSNFWPQVILPLQ 156

  Fly   347 --------MLCLIGEAC-KHSDDLCGVVVNIRGKSNKISIWNADGGNQTTVLEIGRILRKVLRMD 402
                    :||||||:. .:|||:||.|||:|.|.:||:||..:..|:..|..|||:.::.|.:.
Human   157 PPKVLELQLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLP 221

  Fly   403 NIYVLEYQLHKDSKDKLGSTVKRIYTV 429
            ...|:.||.|.|:..|.|||.|..:.|
Human   222 PKIVIGYQSHADTATKSGSTTKNRFVV 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4E7	NP_726718.1	IF4E	255..409	CDD:279921	76/186 (41%)
EIF4E	NP_001124151.1	IF4E	38..228	CDD:366742	78/189 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140837
Domainoid	1	1.000	187	1.000	Domainoid score	I3336
eggNOG	1	0.900	-	-		E1_COG5053
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123817
Inparanoid	1	1.050	214	1.000	Inparanoid score	I3630
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1394271at2759
OrthoFinder	1	1.000	-	-		FOG0000666
OrthoInspector	1	1.000	-	-		mtm8454
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11960
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R595
SonicParanoid	1	1.000	-	-		X406
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.890