Protein Alignment su(w[a]) and SFSWAP

DIOPT Version :10

• Sequence 1: NP_476756.2
• Gene: su(w[a]) / 31054
• FlyBaseID: FBgn0003638
• Length: 963
• Species: Drosophila melanogaster
• Sequence 2: NP_001248340.1
• Gene: SFSWAP / 6433
• HGNCID: 10790
• Length: 1003
• Species: Homo sapiens
• Alignment Length: 1076
• Identity: 312/1076 - (28%)
• Similarity: 453/1076 - (42%)
• Gaps: 267/1076 - (24%)

  Fly    12 GSVGGIL---RRTGQGSGTGSTILGNGNSPGALGAGKVSSSLENHRQPPLELLVFGYACKIFRDD 73
            |:.||..   |::|.....|         ||..|.|          ...:||||||||||:||||
Human     3 GASGGRAKPERKSGAKEEAG---------PGGAGGG----------GSRVELLVFGYACKLFRDD 48

  Fly    74 EKAREMDHGKQLIPWMGDVNLKIDRYDVRGALCELAPHEAPPGGYGNRLEYLSAEEQRAEQLCEE 138
            |:|...:.|:.|||||||..:.|||||.||.|.:|:.::|....: ||...||.||.|.|.||:|
Human    49 ERALAQEQGQHLIPWMGDHKILIDRYDGRGHLHDLSEYDAEYSTW-NRDYQLSEEEARIEALCDE 112

  Fly   139 ERYLFLYNNEEELRLRQEEDLKRLQQE-TSGGCFSQVGFQYDGQSAASTSIGGS-----STATSQ 197
            ||||.|:.:..|...||||:.|||.:. ...|.::.|||.|           ||     |..|.:
Human   113 ERYLALHTDLLEEEARQEEEYKRLSEALAEDGSYNAVGFTY-----------GSDYYDPSEPTEE 166

  Fly   198 LSP----------NSEESELPFVLPYTLMMAPPLDMQLPETMKQHAIIEKTARFIATQGAQMEIL 252
            ..|          |.||:|.|||.|  |.::.|.|::||.|.|.|||||:||.|:..||||.||:
Human   167 EEPSKQREKNEAENLEENEEPFVAP--LGLSVPSDVELPPTAKMHAIIERTASFVCRQGAQFEIM 229

  Fly   253 IKAKQANNTQFDFLTQGGHLQPYYRHLLAAIKAAKFPPAPQTPLDQQNTDKEAPSADDHSEEVAG 317
            :|||||.|:|||||....:|.|||:.:..|:|..::....:...|::.....:...:|..:|..|
Human   230 LKAKQARNSQFDFLRFDHYLNPYYKFIQKAMKEGRYTVLAENKSDEKKKSGVSSDNEDDDDEEDG 294

  Fly   318 GRRNPNQVVITVPTIKYKPSANC-AYTQLISKIKGV----PLQAVLQEDESSNPGNSQHSGGTAS 377
            ...:|:...          |..| ...:|:..:|.|    ||.|::::        :|....|.:
Human   295 NYLHPSLFA----------SKKCNRLEELMKPLKVVDPDHPLAALVRK--------AQADSSTPT 341

  Fly   378 PALSCRSEGHNSQGGEFTPVLLQYNGSTFTHEEESSNREQQDDNDVNGGEPPQVELLKNTSALAL 442
            |        ||:.|....|..::|...:.......|.....|........||.:::....|.|..
Human   342 P--------HNADGAPVQPSQVEYTADSTVAAMYYSYYMLPDGTYCLAPPPPGIDVTTYYSTLPA 398

  Fly   443 AQNYSSESEEEEDQVQPEKEEEKKP--------------------EPVLTFPVPKDSLRHIIDKT 487
            ....|:..........|.......|                    .||.....|...::.:|||.
Human   399 GVTVSNSPGVTTTAPPPPGTTPLPPPTTAETSSGATSTTTTTSALAPVAAIIPPPPDVQPVIDKL 463

  Fly   488 ATYVIKNGRQFEETLRTKSVDRFSFLLPANEYYPYY-------LYKVTGD------------VDA 533
            |.||.:||.:||.::|.|:..||.||.|.::|..||       |.|..||            .|:
Human   464 AEYVARNGLKFETSVRAKNDQRFEFLQPWHQYNAYYEFKKQFFLQKEGGDSMQAVSAPEEAPTDS 528

  Fly   534 ASK------EEKTRKAAAVAAALMSKKGLSFGGAAAAVSGSNLDK---APVSFSIRARD-DQCPL 588
            |.:      |:...:.||...|.....|.....::..|....|.|   ||:||:|:|:: |..||
Human   529 APEKPSDAGEDGAPEDAAEVGARAGSGGKKEASSSKTVPDGKLVKASFAPISFAIKAKENDLLPL 593

  Fly   589 QHT---LPQEASDEETSSNAAGVEHVRPGMPDSVQRAIKQVETQLLARTAGQKGNITASPSC--- 647
            :..   |..::.|:|.|...                   |..:...|.|     |...:|.|
Human   594 EKNRVKLDDDSDDDEESKEG-------------------QESSSSAANT-----NPAVAPPCVVV 634

  Fly   648 --SSPQ-----KEQRQAEERVKDKLAQIAREKL--NGMISREKQLQLERKRKALAFLNQIKGEGA 703
              ..||     .|.:||:::::|:||..|||||  ....|:|||||.||||||..||..:|
Human   635 EEKKPQLTQEELEAKQAKQKLEDRLAAAAREKLAQASKESKEKQLQAERKRKAALFLQTLK---- 695

  Fly   704 IVGSAVPVVGPNP-PESAAGAATADSGDESGDSV--------------RSIPITYFGPDDDDEVG 753
                       || ||:.||..     :||..||              |.:|.....|.|
Human   696 -----------NPLPEAEAGKI-----EESPFSVEESSTTPCPLLTGGRPLPTLEVKPPD----- 739

  Fly   754 EQRPEMRLIGSTQKDEEDDDEEDGGDLE------------KYNLLNDDSTNTFT-SKPVLPP--- 802
              ||     .|..||...::|::....:            ||:..:...:.:.: :|..||.
Human   740 --RP-----SSKSKDPPREEEKEKKKKKHKKRSRTRSRSPKYHSSSKSRSRSHSKAKHSLPSAYR 797

  Fly   803 -------TAAP---------PPAAVLLSDDDDVQLVATTSTR--SSSSRHLKTHRRSRSRSKNVR 849
                   ||:|         ..|:|..:.:......|:|:||  |:||...|..:.|||||::.|
Human   798 TVRRSRVTASPGTLRAEPCQSSASVTAAAEPGSYQAASTTTRFDSASSFEGKPGKTSRSRSRSPR 862

  Fly   850 SSDSSPSSRESSRRRRQKS----SRLSREPSSNPPRKSQHSSTQRKKTPKKRRRSKSRSRSKSIR 910
            ....||     .|||.::|    .|:||.|.::..|....|..::||..:.|.|:||::||:|:.
Human   863 RRAHSP-----ERRREERSVPTAYRVSRSPGASRKRTRSRSPHEKKKKRRSRSRTKSKARSQSVS 922

  Fly   911 RS-----RSISILRNNRRSRSRSP-SCRNAEQRRQQ 940
            .|     |..:...::..|.|.|| ..|.:.|.|.:
Human   923 PSKQAAPRPAAPAAHSAHSASVSPVESRGSSQERSR 958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
su(w[a])	NP_476756.2	DRY_EERY	60..180	CDD:462881	62/120 (52%)
		SWAP	232..284	CDD:197818	30/51 (59%)
		SWAP	481..527	CDD:197818	21/52 (40%)
SFSWAP	NP_001248340.1	DRY_EERY	35..155	CDD:462881	62/131 (47%)
		SWAP	209..262	CDD:197818	30/52 (58%)
		SWAP	457..508	CDD:197818	20/50 (40%)
		rpsP	<637..718	CDD:237744	38/100 (38%)