DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment su(w[a]) and sfswap

DIOPT Version :9

Sequence 1:	NP_476756.2	Gene:	su(w[a]) / 31054	FlyBaseID:	FBgn0003638	Length:	963	Species:	Drosophila melanogaster
Sequence 2:	NP_957462.2	Gene:	sfswap / 394143	ZFINID:	ZDB-GENE-040426-931	Length:	958	Species:	Danio rerio

Alignment Length:	990	Identity:	299/990 - (30%)
Similarity:	423/990 - (42%)	Gaps:	228/990 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 ELLVFGYACKIFRDDEKAREMDHGKQLIPWMGDVNLKIDRYDVRGALCELAPHEAPPGGYGNRLE 123
            ||||||||||:|||||:|...|.||.|||||||.|:.|||||.||.|.:|:.::|   |..|...
Zfish    26 ELLVFGYACKLFRDDERAFYHDQGKHLIPWMGDKNIMIDRYDGRGHLHDLSEYDA---GSWNHDY 87

  Fly   124 YLSAEEQRAEQLCEEERYLFLYNNEEELRLRQEEDLKRLQQETSG-GCFSQVGFQ-----YDGQS 182
            .||.||.|.|.||:|||||.::.:..|...||||:.|||.:..:. |.::.|.|:     ||...
Zfish    88 QLSEEEARIEALCDEERYLAMHTDLLEEEARQEEEYKRLSEALADEGTYNAVAFRYSADYYDPSQ 152

  Fly   183 AASTSIGGSSTATSQLSPNSEESELPFVLPYTLMMAPPLDMQLPETMKQHAIIEKTARFIATQGA 247
            ..............||   .||||.|||.|..|::.|  |::||.|.|.|||||:||.|:..|||
Zfish   153 PTEEDEASKEADQEQL---EEESEEPFVAPPGLLIPP--DVELPATTKTHAIIERTANFVCKQGA 212

  Fly   248 QMEILIKAKQANNTQFDFLTQGGHLQPYYRHLLAAIKAAKFPPAPQTPLDQQNTDKEAPSADDHS 312
            |.||::|||||.|:|||||....:|.|||:|:|.|:|..::.||.:...|||...|...|.||
Zfish   213 QFEIVLKAKQAGNSQFDFLRFDHYLNPYYKHILRAMKEGRYTPASEGKQDQQQESKSDESDDD-- 275

  Fly   313 EEVAGGRRNPNQVVITVPTIKYKPSANCAYTQLISKIKGV----PLQAVLQEDESSNPGNSQHSG 373
            ::..|...:|:         .:.|.......::|..::.:    ||.|::::.:       |.:.
Zfish   276 DDGDGNYLHPS---------LFAPKKCSRLEEIIKPLQVIDPDHPLAALVRKAQ-------QQNN 324

  Fly   374 GTASPALSCRSEGHNS---QGGEFTP---VLLQYNG------STF-----------THEEESSNR 415
            |||:...:...|...|   ...|:|.   |...|.|      .|:           :|...|...
Zfish   325 GTAALVTNAEEEHQPSAVATQAEYTSDPNVAAMYYGYCMLPDGTYCLAPPPPGIDASHYYASLPT 389

  Fly   416 EQQDDNDVNGGEP--------PQVELLK-------NTSALALAQNYSSESEEEEDQVQPEKEEEK 465
            ........:|..|        |.|.:..       ..||.|.|....|.........:|.:....
Zfish   390 GMMPAPPASGPPPPPGTTPLDPAVAIPSAPAVGPVTVSAPASAPLPHSAPAPPTSSSRPPQTTVV 454

  Fly   466 KPEPVLT-------FPVPKDSLRHIIDKTATYVIKNGRQFEETLRTKSVDRFSFLLPANEYYPYY 523
            .|..|.|       .|.|.| ::.:|||.|.||.:||.:||.::|.|:..||.||...::|..||
Zfish   455 PPPVVATAAPVAAIIPPPPD-IQPVIDKLAEYVARNGVKFETSVRAKNDPRFDFLQSWHQYNSYY 518

  Fly   524 LYKVTGDVDAASKEEKTRKAAAVAAALMSKKGLS-------FGGAAAAVSGSNLDK--------- 572
            .:|                    ....|.|:|||       :|....:...|: ||
Zfish   519 EFK--------------------KHYFMQKEGLSGQEGSLLYGSGGDSAENSS-DKQQDEGKLIK 562

  Fly   573 ---APVSFSIRARD-DQCPLQHTLPQ--EASDEETSSNAAGVEHVRPGMPDSV--QRAIKQVETQ 629
               ||:.|:|:::: |..||:....:  :.|||:....     .|..||..::  ..|.::|...
Zfish   563 ASFAPICFAIKSKENDLLPLEKNRVRLDDDSDEDAIKG-----DVLEGMELAIGLLEAPREVPQP 622

  Fly   630 LLARTAGQKGNITASPSCSSPQKEQRQAEERVKDKLAQIAREKL--NGMISREKQLQLERKRKAL 692
            .||.        ...|..|..:.|.:||:::::|:||..|||||  ....|:|:|||.||||||.
Zfish   623 PLAE--------EKKPVLSQEELEAKQAKQKLEDRLAAAAREKLAQASKESKERQLQAERKRKAA 679

  Fly   693 AFLNQIKG-EGAIVGSAVPVVGPNPPESAAGAATADSGDESGDSVRSIPITYFGPDDDDEVGEQR 756
            .||..::| |..:..:......|.|..|.                  :||:          |..:
Zfish   680 LFLQTLRGPEAEVKRTEETTAAPEPLGSI------------------LPIS----------GLLQ 716

  Fly   757 PEMRLIGSTQKDEEDDDEEDGGDLEKYNLLNDDSTNTFTSKPVLPPTAAPPPAAVLLSDDDDVQL 821
            ...|:              .|.|.|........|.|...|.
Zfish   717 HTCRI--------------PGFDYEPLENALTRSLNNAASH------------------------ 743

  Fly   822 VATTSTRSSSSRHLKTHRRSRSRSKNVRSSDSSPSSRESSRRRRQKSSRLSREPSSNPPRKSQHS 886
             .||||.|||||   ...|.|.|.:: |..|.....::..||.|.:|...||..|     |::|:
Zfish   744 -VTTSTSSSSSR---GPERDRDRDRD-RDRDRDKRKKKHKRRSRSRSRSRSRSKS-----KTKHA 798

  Fly   887 STQRKKTPKKRRRSKSRSRSKSIRRSRSISILRNNRRSRSRSPS----CRNAEQRRQQDRRRTPT 947
            .....:| .:|.||:|||.|:..||:||....|:.|...|..||    ..|....||:.|.|:|
Zfish   799 LPSAYRT-FRRSRSQSRSPSRRDRRARSPDRKRDEREKESYGPSNYRLGSNPALGRQRSRSRSP- 861

  Fly   948 KKSHKRHKRRRRSSS 962
               |::.||:...||
Zfish   862 ---HEKKKRKSSKSS 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(w[a])	NP_476756.2	DRY_EERY	60..180	CDD:286793	63/125 (50%)
		SWAP	232..284	CDD:197818	32/51 (63%)
		SWAP	481..527	CDD:197818	19/45 (42%)
sfswap	NP_957462.2	DRY_EERY	27..143	CDD:286793	62/118 (53%)
		SWAP	197..250	CDD:197818	32/52 (62%)
		SWAP	480..521	CDD:197818	18/40 (45%)
		PhaG_MnhG_YufB	<605..698	CDD:294390	34/100 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596298
Domainoid	1	1.000	117	1.000	Domainoid score	I5881
eggNOG	1	0.900	-	-		E1_KOG1847
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	312	1.000	Inparanoid score	I2567
OMA	1	1.010	-	-		QHG60281
OrthoDB	1	1.010	-	-		D1414730at2759
OrthoFinder	1	1.000	-	-		FOG0006145
OrthoInspector	1	1.000	-	-		oto38969
orthoMCL	1	0.900	-	-		OOG6_105736
Panther	1	1.100	-	-	LDO	PTHR13161
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2829
SonicParanoid	1	1.000	-	-		X5079
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.890