Protein Alignment Cdc45 and CDC45

DIOPT Version :10

• Sequence 1: NP_569880.1
• Gene: Cdc45 / 31052
• FlyBaseID: FBgn0026143
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001171481.1
• Gene: CDC45 / 8318
• HGNCID: 1739
• Length: 598
• Species: Homo sapiens
• Alignment Length: 617
• Identity: 234/617 - (37%)
• Similarity: 371/617 - (60%)
• Gaps: 61/617 - (9%)

  Fly     1 MFVQDLRNDFYRQLVGKRILIVVNYDIDAICASRILQALFKYDHMLYTVVPIMGVTGLKRAYGEH 65
            |||.|.|.:||..:..:|:|:.|..|:||:||.:||||||:.||:.||:||:.|...|:.|:.||
Human     1 MFVSDFRKEFYEVVQSQRVLLFVASDVDALCACKILQALFQCDHVQYTLVPVSGWQELETAFLEH 65

  Fly    66 QGDVKYVVLVNCGGCVDIVELLQPSDDVTFFICDSHRPLDVCNIYSDRQVCIL--GDASLEENIP 128
            :....|.:|:|||..||::::|||.:|..||:||:|||::|.|:|:|.|:.:|  .|..||  :|
Human    66 KEQFHYFILINCGANVDLLDILQPDEDTIFFVCDTHRPVNVVNVYNDTQIKLLIKQDDDLE--VP 128

  Fly   129 AFETIFYDSEGEDEDEDESSDTEQQHDDSGAGESDQEDQAPRSRKLSRLERH-EQRILKQRARRQ 192
            |:|.||.|   |:|||:.|.             :|.:...| |.|.:|||.. .::.:::|.||:
Human   129 AYEDIFRD---EEEDEEHSG-------------NDSDGSEP-SEKRTRLEEEIVEQTMRRRQRRE 176

  Fly   193 WE--------------------------------SERDRIMFEYTQFSYYGRSAALMVFELAWKL 225
            ||                                |.|..|:|:|.|:.|:|.|:|:::|||||.|
Human   177 WEARSGSGSEPVAAALEKSSRLFAGPMSDRTAPRSPRRDILFDYEQYEYHGTSSAMVMFELAWML 241

  Fly   226 SKDNMDLLWWAIVGITEQLLLGKIESGAYTLELEQIQSHVSRLTNKTND-QNTMS--ASKITFEN 287
            |||..|:|||||||:|:|.:..||....|..::..:|.||||..::..| :||:|  .::|:||.
Human   242 SKDLNDMLWWAIVGLTDQWVQDKITQMKYVTDVGVLQRHVSRHNHRNEDEENTLSVDCTRISFEY 306

  Fly   288 DLHLVLYRHWPVTESMRYSRYSSCQLKLWTLRGEKRLHELLLEMGLPLVHARQTYGAMDLVLRKE 352
            ||.||||:||.:.:|:..:.|::.:.|||::.|:|||.|.|.:|||||...:|.:.|||:.|::.
Human   307 DLRLVLYQHWSLHDSLCNTSYTAARFKLWSVHGQKRLQEFLADMGLPLKQVKQKFQAMDISLKEN 371

  Fly   353 FFSMVERLAEKYDIADIVYGTFTLSYGYRSRYAAADYVYALLAIMESVKKHKTPEDCFLEASDAL 417
            ...|:|..|.|:.:.|:...||::.:|::.::.|:|.|:|.:::|||.:|..:..|.|::|.|:|
Human   372 LREMIEESANKFGMKDMRVQTFSIHFGFKHKFLASDVVFATMSLMESPEKDGSGTDHFIQALDSL 436

  Fly   418 SRQHKQLLSAGIDQAKLLHAAVFRQVQSSLEARQVHSAGSFFYYVLQE---EHAFFSYPYALGLL 479
            ||.:...|..|::.||....|..:.:.|.|....|.|.|.|.|..|.|   :...||.|.:|.||
Human   437 SRSNLDKLYHGLELAKKQLRATQQTIASCLCTNLVISQGPFLYCSLMEGTPDVMLFSRPASLSLL 501

  Fly   480 ARFLLRGHVATSRARQASDLPLIASCPLNASEGMCLLVGIVPVREDSPR-NFFGKAFEQAAQKSG 543
            ::.||:..|.:::.|:...|||:.:.||:...|...:|||.|..:.|.| ||||:|||:||:.:.
Human   502 SKHLLKSFVCSTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTS 566

  Fly   544 VALLQDFFEPAVVQLRQSDLTRFLDSLTVLLA 575
            ..:|.:.|:.:|::|:..|.::|||:|..||:
Human   567 SRMLHNHFDLSVIELKAEDRSKFLDALISLLS 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdc45	NP_569880.1	CDC45	19..570	CDD:460663	223/592 (38%)
CDC45	NP_001171481.1	CDC45	19..593	CDD:460663	223/592 (38%)