DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc45 and cdc45

DIOPT Version :9

Sequence 1:	NP_569880.1	Gene:	Cdc45 / 31052	FlyBaseID:	FBgn0026143	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_998551.1	Gene:	cdc45 / 406695	ZFINID:	ZDB-GENE-040426-2710	Length:	572	Species:	Danio rerio

Alignment Length:	582	Identity:	243/582 - (41%)
Similarity:	375/582 - (64%)	Gaps:	17/582 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFVQDLRNDFYRQLVGKRILIVVNYDIDAICASRILQALFKYDHMLYTVVPIMGVTGLKRAYGEH 65
            |||.|:|.:||..:|.:|:.::|:.||||:||.::|||||..||:.||:||:.|...|..|:.||
Zfish     1 MFVTDIRKEFYDVVVNQRVALLVSSDIDALCACKVLQALFHCDHVQYTLVPVTGWQDLGTAFLEH 65

  Fly    66 QGDVKYVVLVNCGGCVDIVELLQPSDDVTFFICDSHRPLDVCNIYSDRQVCILGDASLEENIPAF 130
            :...||.||:|||..||::|.|||.:|..|||||:|||:||.|:|:|.|:.:|.....:..:|::
Zfish    66 KEQYKYFVLINCGANVDLLETLQPEEDSVFFICDTHRPVDVVNVYNDSQIKLLIKQDDDLGVPSY 130

  Fly   131 ETIFYDSEGEDEDEDESSDTEQQHDDSGAGESDQEDQAPRSRKLSRLERHEQRILKQRARRQWES 195
            :.||     .|::|||.:|    .|||| .|||...:....|:....:..|:||.:|||||:||:
Zfish   131 DDIF-----RDDEEDEEAD----GDDSG-NESDGSAEPSGKRRRFDEDALERRIERQRARREWEA 185

  Fly   196 ERDRIMFEYTQFSYYGRSAALMVFELAWKLSKDNMDLLWWAIVGITEQLLLGKIESGAYTLELEQ 260
            .|..|:|:|.|:.::|.||||::|||||.:|||..|:|||:|:|:|:|.:..||....|..::..
Zfish   186 RRREILFDYEQYEFHGTSAALVMFELAWVMSKDTKDMLWWSIIGLTDQWVHDKIPHMKYVTDIAT 250

  Fly   261 IQSHVSRLTNKTND-QNTMS--ASKITFENDLHLVLYRHWPVTESMRYSRYSSCQLKLWTLRGEK 322
            :|.||||..:|..| :|::|  ..:|.||.||.||||:||.:.||:..|.|:||..|||::.|:|
Zfish   251 LQRHVSRHNHKNEDEENSLSIDCMRINFEYDLRLVLYQHWSLYESICNSCYTSCSFKLWSINGQK 315

  Fly   323 RLHELLLEMGLPLVHARQTYGAMDLVLRKEFFSMVERLAEKYDIADIVYGTFTLSYGYRSRYAAA 387
            :|.|.|.:|||||...||.:.:||:.:::....::|..|.|:.:.||...||.:.:|:::|:.|:
Zfish   316 KLQEFLADMGLPLKQVRQKFNSMDMTIKENLREVIEESATKFGMKDIRVQTFGVHFGFKNRFLAS 380

  Fly   388 DYVYALLAIMESVKKHKTPEDCFLEASDALSRQHKQLLSAGIDQAKLLHAAVFRQVQSSLEARQV 452
            |.|:|..|::|:|:|.:||.|.|::|.|.|||.:.:.|..|||.||....|:.:.|.|.:....:
Zfish   381 DVVHAAAALLENVEKDETPTDNFIKALDCLSRSNLERLHLGIDLAKKKLKAIQQTVASCICTNLI 445

  Fly   453 HSAGSFFYYVLQE---EHAFFSYPYALGLLARFLLRGHVATSRARQASDLPLIASCPLNASEGMC 514
            .|.|.|.|..|.|   :...||.|.:|.||:::||:..|.::|.::...||||.:.||:..:|..
Zfish   446 LSQGPFLYCHLLEGTPDVKLFSKPLSLTLLSKYLLKAFVCSTRNKRCKILPLIMAAPLDIEKGTV 510

  Fly   515 LLVGIVPVREDS-PRNFFGKAFEQAAQKSGVALLQDFFEPAVVQLRQSDLTRFLDSLTVLLA 575
            :::||.|..|.| .:||||:|||:||:.:....|.|.|:.:|::|:..|..:|||:|..||:
Zfish   511 IVMGIPPESETSDKKNFFGRAFEKAAESTSSRTLHDHFDTSVIELKMEDRGKFLDALITLLS 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc45	NP_569880.1	CDC45	19..571	CDD:367156	231/558 (41%)
cdc45	NP_998551.1	CDC45	19..567	CDD:280821	231/557 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585907
Domainoid	1	1.000	443	1.000	Domainoid score	I511
eggNOG	1	0.900	-	-		E1_KOG2475
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2616
Inparanoid	1	1.050	465	1.000	Inparanoid score	I1511
OMA	1	1.010	-	-		QHG53772
OrthoDB	1	1.010	-	-		D1309031at2759
OrthoFinder	1	1.000	-	-		FOG0004931
OrthoInspector	1	1.000	-	-		oto39839
orthoMCL	1	0.900	-	-		OOG6_102930
Panther	1	1.100	-	-	LDO	PTHR10507
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4027
SonicParanoid	1	1.000	-	-		X4597
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800