DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11638 and RCN3

DIOPT Version :9

Sequence 1:	NP_569879.1	Gene:	CG11638 / 31050	FlyBaseID:	FBgn0040351	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	XP_024307388.1	Gene:	RCN3 / 57333	HGNCID:	21145	Length:	365	Species:	Homo sapiens

Alignment Length:	421	Identity:	84/421 - (19%)
Similarity:	137/421 - (32%)	Gaps:	151/421 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AAVSGDEPDEEQASAVVAEGEDQETQNQAMQDDGQPGGEGHHLSSEKQQSTEQCRQRPRKKLTDK 69
            ||...|.|.::      |.|..|......:         |..::.|..|.|.:..|....::.|:
Human    37 AAPLSDAPHDD------AHGNFQYDHEAFL---------GREVAKEFDQLTPEESQARLGRIVDR 86

  Fly    70 QPQRSAANSHPEQADADTDSSSCEGIKVGQRRGTRVSYAQRNLH---GAELEDYDYDGEGE-GER 130
            ..:         ..|.|      ..:.:.:.|.......||::.   .|..:.||.|.:|. |
Human    87 MDR---------AGDGD------GWVSLAELRAWIAHTQQRHIRDSVSAAWDTYDTDRDGRVG-- 134

  Fly   131 EEDGEEEEEEEESYDDYEQSSKPEGRRPSARTALSVRSRRKTKTRQICYASSDLELGIGDGPNLI 195
                 .||....:|..|....:                            ..|:|
Human   135 -----WEELRNATYGHYAPGEE----------------------------FHDVE---------- 156

  Fly   196 DGETLHKRRCISKGQMREFREAFRLFDKDGDGCITKEELGTV--------MRSL------GQFAR 246
            |.||.  ::.:::.:.|     ||:.|:|||...|:|||...        ||.:      .:|.|
Human   157 DAETY--KKMLARDERR-----FRVADQDGDSMATREELTAFLHPEEFPHMRDIVIALPGAKFPR 214

  Fly   247 --------VEE----------------LQEMLQEIDVDGDGNVSFEEFVDILSNMTYEDKSGLSS 287
                    |:.                |||.|:::|.:.||.|..||::           :.|.|
Human   215 EPLTLTPGVQPPPGARVIGPQPQCPFLLQETLEDLDRNKDGYVQVEEYI-----------ADLYS 268

  Fly   288 ADQEERE------LRDAFRVF-DKHNRGYITASDLRAVLQCLGEDLDEEDIEDMIKEVDVDGDGR 345
            |:..|.|      .|..||.| |.:..|::..|::...:....:|....:...::.|.|.|.|||
Human   269 AEPGEEEPAWVQTERQQFRDFRDLNKDGHLDGSEVGHWVLPPAQDQPLVEANHLLHESDTDKDGR 333

  Fly   346 IDFYEFV---------HALGEPEDSQENDDE 367
            :...|.:         .|....||...:.||
Human   334 LSKAEILGNWNMFVGSQATNYGEDLTRHHDE 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11638	NP_569879.1	EFh	213..275	CDD:238008	25/99 (25%)
		EF-hand_7	215..274	CDD:290234	25/96 (26%)
		EFh	294..355	CDD:238008	16/76 (21%)
		EF-hand_7	295..355	CDD:290234	15/69 (22%)
RCN3	XP_024307388.1	EFh_CREC_RCN3	44..348	CDD:320028	76/396 (19%)
		EF-hand motif	44..73	CDD:320028	7/43 (16%)
		EF-hand motif	79..110	CDD:320028	4/45 (9%)
		EF-hand motif	117..146	CDD:320028	9/35 (26%)
		EF-hand motif	167..196	CDD:320028	11/33 (33%)
		EF-hand motif	204..270	CDD:320028	15/76 (20%)
		EF-hand motif	282..311	CDD:320028	7/28 (25%)
		EF-hand motif	318..348	CDD:320028	7/29 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3636
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860