DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11638 and CABP4

DIOPT Version :9

Sequence 1:	NP_569879.1	Gene:	CG11638 / 31050	FlyBaseID:	FBgn0040351	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	XP_011543483.1	Gene:	CABP4 / 57010	HGNCID:	1386	Length:	295	Species:	Homo sapiens

Alignment Length:	333	Identity:	97/333 - (29%)
Similarity:	145/333 - (43%)	Gaps:	54/333 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GEDQETQNQAMQDDGQPGGEGHHLSSEKQQSTEQCRQRPRKKLTDKQPQRSAANSHPEQADADTD 88
            |||::.|.  :.::...|.:|.:|:..        ||:|                   .|...|.
Human    13 GEDRKVQR--ISEEQARGQQGPNLAIG--------RQKP-------------------PAGVVTP 48

  Fly    89 SSSCEGIKVGQRRGTRVSYAQRNLHGAELEDYDYDGEGEGEREEDGEEEEEEEESYDDYEQSSKP 153
            .|..|...:.::|    |..:|.|.|:. :.....||..|        .|....|.:.......|
Human    49 KSDAEEPPLTRKR----SKKERGLRGSR-KRTGSSGEQTG--------PEAPGSSNNPPSTGEGP 100

  Fly   154 EGRRPSARTALSVRSRRKTKTRQICYASSDLELGIGDGPNLIDGETLHKRRCISKGQMREFREAF 218
            .|..|::....|.|...:.:...:..|:....     ||.|  .....|.|.:...::.|.:.||
Human   101 AGAPPASPGPASSRQSHRHRPDSLHDAAQRTY-----GPLL--NRVFGKDRELGPEELDELQAAF 158

  Fly   219 RLFDKDGDGCITKEELGTVMRSLGQFARVEELQEMLQEIDVDGDGNVSFEEFVDILSNMTYEDKS 283
            ..||.|.||.|:..|||..||:||......||.|:.|.|.:...|.|.|||||:::.....|:.:
Human   159 EEFDTDRDGYISHRELGDCMRTLGYMPTEMELLEVSQHIKMRMGGRVDFEEFVELIGPKLREETA 223

  Fly   284 GLSSADQEERELRDAFRVFDKHNRGYITASDLR-AVLQCLGEDLDEEDIEDMIKEVDVDGDGRID 347
            .:...    ||||.|||.||:...|.||.::|| ||...|||.|...::::|::|||::|||.:|
Human   224 HMLGV----RELRIAFREFDRDRDGRITVAELREAVPALLGEPLAGPELDEMLREVDLNGDGTVD 284

  Fly   348 FYEFVHAL 355
            |.|||..|
Human   285 FDEFVMML 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11638	NP_569879.1	EFh	213..275	CDD:238008	28/61 (46%)
		EF-hand_7	215..274	CDD:290234	27/58 (47%)
		EFh	294..355	CDD:238008	31/61 (51%)
		EF-hand_7	295..355	CDD:290234	30/60 (50%)
CABP4	XP_011543483.1	PHA03415	81..>190	CDD:177643	30/123 (24%)
		PTZ00184	145..294	CDD:185504	62/152 (41%)
		EFh	153..214	CDD:238008	28/60 (47%)
		EFh	230..293	CDD:238008	32/63 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1340191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920