DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11638 and Rcn3

DIOPT Version :9

Sequence 1:	NP_569879.1	Gene:	CG11638 / 31050	FlyBaseID:	FBgn0040351	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	NP_001341974.1	Gene:	Rcn3 / 52377	MGIID:	1277122	Length:	328	Species:	Mus musculus

Alignment Length:	362	Identity:	76/362 - (20%)
Similarity:	129/362 - (35%)	Gaps:	90/362 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 DGQPGGEG--HH---LSSEKQQSTEQCRQRPRKKLTDKQPQRSAANSHPEQADA---------DT 87
            |..|.|:.  ||   ||...........|...:....:...:......||::.|         |.
Mouse    25 DAGPHGQDRVHHGTPLSEAPHDDAHGNFQYDHEAFLGRDVAKEFDKLSPEESQARLGRIVDRMDL 89

  Fly    88 DSSSCEGIKVGQRRGTRVSYAQRNLH---GAELEDYDYDGEGE-GEREEDGEEEEEEEESYDDYE 148
            ...|...:.:.:.|.......||::.   .|....||.|.:|. |       .||....:|..||
Mouse    90 AGDSDGWVSLAELRAWIAHTQQRHIRDSVSAAWHTYDTDRDGRVG-------WEELRNATYGHYE 147

  Fly   149 QSSKPEGRRPSARTALSVRSRRKTKTRQICYASSDLELGIGDGPNLIDGETLHKRRCISKGQMRE 213
            ...:                            ..|:|          |.||.  ::.:::.:.|
Mouse   148 PGEE----------------------------FHDVE----------DAETY--KKMLARDERR- 171

  Fly   214 FREAFRLFDKDGDGCITKEELGTVMRSLGQFARVEEL--QEMLQEIDVDGDGNVSFEEFV-DILS 275
                ||:.|:|||...|:||| |......:|..:.::  .|.|:::|.:.||.|..||:: |:.|
Mouse   172 ----FRVADQDGDSMATREEL-TAFLHPEEFPHMRDIVVAETLEDLDKNKDGYVQVEEYIADLYS 231

  Fly   276 NMTYEDK-SGLSSADQEERELRDAFRVFDKHNRGYITASDLRAVLQCLGEDLDEEDIEDMIKEVD 339
            ....|:: :.:.:..|:.||.||.      :..|.:..|::...:....:|....:...::.|.|
Mouse   232 EEPGEEEPAWVQTERQQFREFRDL------NKDGRLDGSEVGYWVLPPSQDQPLVEANHLLHESD 290

  Fly   340 VDGDGRIDFYEFV---------HALGEPEDSQENDDE 367
            .|.|||:...|.:         .|....||...:.||
Mouse   291 TDKDGRLSKAEILSNWNMFVGSQATNYGEDLTRHHDE 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11638	NP_569879.1	EFh	213..275	CDD:238008	21/64 (33%)
		EF-hand_7	215..274	CDD:290234	21/61 (34%)
		EFh	294..355	CDD:238008	13/69 (19%)
		EF-hand_7	295..355	CDD:290234	12/68 (18%)
Rcn3	NP_001341974.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..48		7/22 (32%)
		EFh_CREC_RCN3	44..311	CDD:320028	64/325 (20%)
		EF-hand motif	44..73	CDD:320028	1/28 (4%)
		EF-hand motif	79..110	CDD:320028	3/30 (10%)
		EF-hand motif	117..146	CDD:320028	9/35 (26%)
		EF-hand motif	167..196	CDD:320028	12/34 (35%)
		EF-hand motif	204..233	CDD:320028	10/28 (36%)
		EF-hand motif	245..274	CDD:320028	7/34 (21%)
		EF-hand motif	281..311	CDD:320028	7/29 (24%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	325..328		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3636
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860