Protein Alignment CG3690 and SV2A

DIOPT Version :9

• Sequence 1: NP_001284764.1
• Gene: CG3690 / 31047
• FlyBaseID: FBgn0040350
• Length: 558
• Species: Drosophila melanogaster
• Sequence 2: NP_001315603.1
• Gene: SV2A / 9900
• HGNCID: 20566
• Length: 742
• Species: Homo sapiens
• Alignment Length: 633
• Identity: 146/633 - (23%)
• Similarity: 250/633 - (39%)
• Gaps: 117/633 - (18%)

  Fly     4 PSESGDPKPHKTAEHQIGDPPQKEAAADFEAAIDAAGFGMFNILLLVAAVPAAMGTVYETSTMSY 68
            |...|:.:..|..|         |.|..:||.:...|.|.|...|......|.|....|...:.:
Human   133 PGGRGEAQRRKERE---------ELAQQYEAILRECGHGRFQWTLYFVLGLALMADGVEVFVVGF 188

  Fly    69 ILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQ 133
            :|||||.|:.||..:||:|..|.|.||:..|.|||.|||..|||..|::..:.:::.....:..|
Human   189 VLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQ 253

  Fly   134 SRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIMMMVGIMFSIATLTLPGLAMLILPE- 197
            .....:..:.|.|..:.|...::.:|.:|...::.|...:..:.:.:.|..:....:|..|:|.
Human   254 GYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHY 318

  Fly   198 TWNIQIWT-LSLTSWQFFVAVTALPSLLSFVLFFFFPESPKFLMSKGRNREALDAFKFMYHLNSR 261
            .|:.|:.: ....||:.||.|.|.||:.:.......||||:|.:..|::.||....|.::..|.|
Human   319 GWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMR 383

  Fly   262 ---KPKDSFPIKLLANEVIVPVKKHAKDETIPTELKLPTECVEVQDPENQDSKKSSLRS------ 317
               .|:..|.:            .|.|  ||..|    .|.:|:|.......::..:|:
Human   384 AKGHPERVFSV------------THIK--TIHQE----DELIEIQSDTGTWYQRWGVRALSLGGQ 430

  Fly   318 GFTQLRPLFTKPYLGLSLWVYLLNFCVLLGQNTMRLWLPQLFASINEYE-----NLMSGESQSTS 377
            .:......|...|..::|.:..:.|.:......:.:|.|.:...:...:     .:..||.....
Human   431 VWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYASRTKVFPGERVEHV 495

  Fly   378 ICNI-LEYSVNRTQS---------QLEAVTRNDPTVE----------------CHVIIT------ 410
            ..|. ||..::|...         :|::|:..|...|                |..|.|
Human   496 TFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTD 560

  Fly   411 ------------PSTYTNN-----LIVAGAGFVAYMLAGFLVNLVGVKLIMTSGLLIA------- 451
                        .||:.:|     |.|.|.|..|||:  :.|:.:|...::...::.|
Human   561 LFEYKFVNSRLINSTFLHNKEGCPLDVTGTGEGAYMV--YFVSFLGTLAVLPGNIVSALLMDKIG 623

  Fly   452 -----AGCSI-------GMYWSSSAASTVALASLF--VTMGSISATSVISASVSLFPTSLRTMIV 502
                 ||.|:       .:.:.:|.::.:||..||  |::.|.:|..|:  :|.|:|:..||...
Human   624 RLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVL--TVELYPSDKRTTAF 686

  Fly   503 SLEMMFGRLGSLLGNIFFPALMGLGCVPPFLMISAFMLAGCFMAAFLP 550
            .......:|.::||...|.:.:|:....|.|..||.:..|..:|..||
Human   687 GFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLALKLP 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3690	NP_001284764.1	SP	42..549	CDD:273317	135/592 (23%)
		MFS	49..>195	CDD:119392	38/145 (26%)
		MFS	419..>550	CDD:119392	37/151 (25%)
SV2A	NP_001315603.1	synapt_SV2	1..742	CDD:130366	146/633 (23%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	33..144		2/10 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724235at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8480
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920