DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3690 and slc22a21

DIOPT Version :9

Sequence 1:	NP_001284764.1	Gene:	CG3690 / 31047	FlyBaseID:	FBgn0040350	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_001295487.1	Gene:	slc22a21 / 799908	ZFINID:	ZDB-GENE-091118-62	Length:	546	Species:	Danio rerio

Alignment Length:	584	Identity:	113/584 - (19%)
Similarity:	209/584 - (35%)	Gaps:	173/584 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PKPHKTAEHQIGDPPQKEAAADFEAAID-----AAGFGMFNILLLVAAVP---AAMGTVYETSTM 66
            |:||       |||   .|:..:...:|     :.|..:..:.:.|:.:|   .|.|.:|:....
Zfish    72 PQPH-------GDP---RASRCYRLRLDLVKNYSDGGLLPGLDVNVSEIPREECADGWIYDKEIY 126

  Fly    67 SYILPSAECDLKLSLLDKG-ILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGA 130
            |..:.| |.||..|...|. :.::|.:.|:::.:|:.|.::|..||:.:|.|..|..|:..:...
Zfish   127 SSTIVS-EWDLVCSDDWKSPLTSSIFFCGVLTGSVISGPVSDRFGRKIVLFVTMAIQTLFTVVQV 190

  Fly   131 LSQS-RIQLMVF---------KYLGGFCMSGPFAVLMTYLTELHGRKHRQRIMMMVGIMFSIATL 185
            .|.| :|...:|         .|:..|.:.  ..:|.:.:.:::.       .:.|.:.|||..:
Zfish   191 FSPSWQIFCFLFFIVGMGQISNYVAAFVLG--MEILSSSVRDVYS-------TLGVCLFFSIGYM 246

  Fly   186 TLPGLAMLILPETWNIQIWTLSLTSWQFFVAVTALPSLLSFVLFFFFPESPKFLMSKGRNREALD 250
            .||..|..              |..|:..:....:|......|::|.||||::|:|:||.:||..
Zfish   247 ILPLAAFF--------------LRDWRSLMLALTIPGFFYIPLWWFIPESPRWLLSQGRVQEAEA 297

  Fly   251 AFKFMYHLNSRKPKDSFPIKLLANEVIVPVKKHAKDETIPTELKLPTECVEVQDPENQDSKKSSL 315
            ..:....:|          ::.|.:||.|:.:..:|
Zfish   298 IIRKAAKIN----------RVTAPDVIFPLMQSTED----------------------------- 323

  Fly   316 RSGFTQLRPLFTKPYLGLSLWVYLLNFCVLLGQNTMRLWLPQLFASINEYENLMSGESQSTSICN 380
                                                                  :|..||.|:|.
Zfish   324 ------------------------------------------------------AGGVQSFSVCE 334

  Fly   381 ILEYSVNRTQSQLE------------AVTRNDPTVECHVIITPSTYTNNLIVAGAGFVAYMLAGF 433
            :|:.|..|..:.|.            |::.|..::..::      |.|.|:.|.....|.::|..
Zfish   335 LLKSSNIRYMTGLLCLIWMAVSIGYCALSLNTSSLHGNI------YLNCLLSAVVEVPALLMAWL 393

  Fly   434 LVNLVGVKLIMTSGLLIAAGCSIGMYWSSSAASTVALASLFV-TMGSISATSVI-SASVSLFPTS 496
            ::.|...:..:.|.|.:.....:.:.......|:|.||.:.: ..|..:|.|:| ..:..|:||.
Zfish   394 MLRLAPRRHCLASTLALGGLVLLLILLIPEDQSSVTLALVMLGKFGLSAAFSIIYPVTAELYPTV 458

  Fly   497 LRTMIVSLEMMFGRLGSLLGNIFFPALMGLGCVP---PFLMISAFMLAGCFMAAFLPLKNKAAL 557
            ||...:....|..|    :|.|..|....||...   |:::|....:....::..||....:||
Zfish   459 LRNTALGACSMSSR----VGGISAPYFNYLGSYHRSLPYILIGGINVLSGLLSFLLPESRGSAL 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3690	NP_001284764.1	SP	42..549	CDD:273317	100/537 (19%)
		MFS	49..>195	CDD:119392	37/159 (23%)
		MFS	419..>550	CDD:119392	28/135 (21%)
slc22a21	NP_001295487.1	2A0119	14..521	CDD:273328	113/584 (19%)
slc22a21	NP_001295487.1	MFS	146..511	CDD:119392	88/490 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588419
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930