DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3690 and sv2ca

DIOPT Version :9

Sequence 1:	NP_001284764.1	Gene:	CG3690 / 31047	FlyBaseID:	FBgn0040350	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_001121811.1	Gene:	sv2ca / 562345	ZFINID:	ZDB-GENE-060526-233	Length:	745	Species:	Danio rerio

Alignment Length:	685	Identity:	153/685 - (22%)
Similarity:	256/685 - (37%)	Gaps:	176/685 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EPSESGDPKPHKTAEHQI--GDP-----------------PQKEAAADFEAAIDAAGFGMFNILL 48
            |....|.|...|..:.|:  |.|                 .::|.|..:|..|...|.|.|...|
Zfish    92 EGEYQGIPSDAKARDGQVALGQPLSDGLKDRRELENERQADEEELAQQYELIIQECGHGRFQWQL 156

  Fly    49 LVAAVPAAMGTVYETSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRN 113
            ......|.|....|...:.::|||||.|:.:.....|.|.:|.|.||:..|..||.:||..|||.
Zfish   157 FFTLGLALMSDGVEVFVVGFVLPSAETDMCVPDSSSGWLGSIVYLGMMVGAFFWGGMADKVGRRQ 221

  Fly   114 LLIVGYAADTICV-LGG--ALSQSRIQ----LMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQR 171
            .|:       ||: |.|  |...|.:|    .::.:.:.||.:.|...::.:|..|:..|:.|..
Zfish   222 CLL-------ICMSLNGFFAFLSSFVQGYGLFLLCRMIAGFGIGGAVPIVFSYFAEVLAREKRGE 279

  Fly   172 IMMMVGIMFSIATLTLPGLAMLILPETWNIQI-------------WTLSL------TSWQFFVAV 217
            .:..:.:.:.|..:....:|..|:|....|..             |:.|:      .||:.||.|
Zfish   280 HLSWLCMFWMIGEIYASAMAWAIIPHYGQITTASSQFINYHHYTSWSFSMGSAYQFHSWRVFVVV 344

  Fly   218 TALPSLLSFVLFFFFPESPKFLMSKGRNREALDAFKFMYHLNSR---KPKDSFPIKLLANEVIVP 279
            .|||.:.:.|...|.||||:|.:..|::.||....|.::..|.|   :|:..|.:    |.:.:|
Zfish   345 CALPCVCAVVALTFMPESPRFYLEVGKHDEAWMILKQIHDTNMRARGQPEKVFTV----NRIKIP 405

  Fly   280 VKKHAKDETIPTELKLPTECVEVQDPENQDSK-----KSSLRSGFTQLRPLFTKP---------- 329
                          |...|.||:.:..|..||     |:.|...:......|..|
Zfish   406 --------------KQIDEFVEMHESGNFFSKAIFRIKTELHGIWLNFLKCFNYPVKESTVKLAI 456

  Fly   330 --------YLGLSLWV--------------------------YLLNFCVLLGQNTMRLWLPQLFA 360
                    |.|||:|.                          :..||.:....:|..|::...|.
Zfish   457 VWLTLSFGYYGLSVWFPDVIKHLQNDEYASKGQRHNNERIEDFTFNFTLENQIHTNSLFINDRFI 521

  Fly   361 SIN-EYENLMSGESQS------TSI------CNILE---YSVNRTQSQLEAVTRNDPTVECHVII 409
            ::. :....::...||      ||:      |..:|   |:.:...|:|    :|...:.
Zfish   522 NMKFKSVTFINSTFQSCFFEDVTSVGSFFRNCTFIEAVFYNTDIDDSKL----KNTDVIN----- 577

  Fly   410 TPSTYTNN----LIVAGAGFVAYMLAGFLVNLVGV------------------KLIMTSGLLIAA 452
              ||:.:|    .:.....:.||.:  :.||.:|.                  :|.|....:|.:
Zfish   578 --STFYHNKTGCQMTFEDDYSAYWV--YFVNFLGTLAVLPGNIVSALLMDKIGRLSMLGFSMILS 638

  Fly   453 GCSIGMYW-SSSAASTVALASLFVTMGSISA-TSVISASVSLFPTSLRTMIVSLEMMFGRLGSLL 515
            |.|....| .:|.:..:.:..|:..: |||| .|:...:..|:||..|...........:|.:::
Zfish   639 GISCFFLWFGTSESMMIGMLCLYNGL-SISAWNSLDVVTTELYPTDRRGTGFGFCNALCKLAAVM 702

  Fly   516 GNIFFPALMGLGCVPPFLMISAFMLAGCFMAAFLP 550
            ||:.|.:|:|:....|.|:.|:.::.|..:...||
Zfish   703 GNLIFGSLVGITKAIPILLASSVLVGGGLVGLRLP 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3690	NP_001284764.1	SP	42..549	CDD:273317	139/624 (22%)
		MFS	49..>195	CDD:119392	40/152 (26%)
		MFS	419..>550	CDD:119392	32/150 (21%)
sv2ca	NP_001121811.1	synapt_SV2	3..745	CDD:130366	153/685 (22%)
		Spt5_N	73..>141	CDD:288770	9/48 (19%)
		MFS	157..>360	CDD:119392	55/209 (26%)
		MFS	588..>711	CDD:119392	26/125 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724235at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920