DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3690 and slc22a15

DIOPT Version :9

Sequence 1:	NP_001284764.1	Gene:	CG3690 / 31047	FlyBaseID:	FBgn0040350	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_001103169.1	Gene:	slc22a15 / 555262	ZFINID:	ZDB-GENE-070928-5	Length:	497	Species:	Danio rerio

Alignment Length:	572	Identity:	119/572 - (20%)
Similarity:	197/572 - (34%)	Gaps:	159/572 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DFEAAIDAAG-FG-----MFNIL--------------LLVAAVP---------AAMGTVYETSTM 66
            |.|.|....| ||     |..:|              :||.|||         ...|.|.::...
Zfish     2 DLEEAFQVVGEFGSHQKRMITVLVFLQIYMACQSMLIILVGAVPEYHIEPVTEGVDGDVTQSVKF 66

  Fly    67 SYILPSAECD---LKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLG 128
            :..:.|...:   :|.......:..::.:||::...|::|.|:|..||:.:.:.|...:.:...|
Zfish    67 TEDVNSIVTEWYLVKHQAYKVNLAGSLFFAGVLIGNVVFGPLSDKIGRKPVFLTGLFFEVLFGYG 131

  Fly   129 GALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLT-ELHGRKHRQRIMMMVGIMFSIATLTLPGLAM 192
            .||:.|.....|.:.|.| .|:|..|::...|| |..|:.:......:..:.|::.......|..
Zfish   132 TALAPSYEAFAVSRLLVG-VMNGGMALVCFVLTQEYVGKSYWAMTGTLTNMTFAVGISLFAALGY 195

  Fly   193 LILPETWNIQIWTLSLTSWQFFVAVTALPSLLSFVLFFFFPESPKFLMSKGRNREALDAFKFMYH 257
            .:.|              |:........|.||.|:|....||||::|.|:|...:|.|..:
Zfish   196 YVRP--------------WRNLATAANCPGLLLFLLCVTLPESPRWLYSRGYTEKAEDILQ---- 242

  Fly   258 LNSRKPKDSFPIKLLANEVIVPVKKHAKDETIPTELKLPTECVEVQDPENQDSKKSSLRSGFTQL 322
                    .|.::.....::|.:::                         ..|..:|...|..|
Zfish   243 --------DFALRNGKGRIVVKLRR-------------------------ASSSPNSSSPGVFQ- 273

  Fly   323 RPLFTKPYLGLSLWVYLLNFCVLLGQNTMRLWLPQLFASINEYENLMSGESQSTSICNILEYSVN 387
              |.|.|.|   .|..::         .|.:|.                      .|:::.|.:.
Zfish   274 --LVTHPVL---RWRTVV---------LMYVWY----------------------ACSLVYYGLT 302

  Fly   388 RTQSQLEAVTRNDPTVECHVIITPSTYTNNLIVAGAGFV---AYMLAGFLVN--LVGVKLIMTSG 447
            ....:.:.                   ...|.||..|.|   ||.|..:.:|  ..|.:..|.:.
Zfish   303 LNAGEDKG-------------------NRYLSVAMYGLVELPAYPLCMYFINKPWAGRRKSMANF 348

  Fly   448 LLIAA-GCSIGMY--WSSSAASTVALASLFVTMGSISATSVISASVSLFPTSLRTMIVSLEMMFG 509
            |..|. .|.:.|.  .|.|..|..:||.:...|.|.:...|...:..|:||.:|...:.:..|..
Zfish   349 LAFAGISCLLTMVVPVSGSLLSATSLALVGKLMVSAAFNIVYVYTSELYPTVIRNAGLGVCSMSC 413

  Fly   510 RLGSLLGNIFFPALMGLGCVPPFLMISAFML----AGCFMAAFLP-LKNKAA 556
            |:|.:|.. |.|::..|....||::   |.|    ||| :...|| ..||.|
Zfish   414 RVGGILAP-FVPSMKSLHTSMPFMV---FCLSGISAGC-LGLLLPETLNKPA 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3690	NP_001284764.1	SP	42..549	CDD:273317	109/550 (20%)
		MFS	49..>195	CDD:119392	34/158 (22%)
		MFS	419..>550	CDD:119392	40/142 (28%)
slc22a15	NP_001103169.1	2A0119	11..463	CDD:273328	116/563 (21%)
slc22a15	NP_001103169.1	MFS	87..453	CDD:119392	97/478 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588858
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930