DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3690 and SLC22A15

DIOPT Version :9

Sequence 1:	NP_001284764.1	Gene:	CG3690 / 31047	FlyBaseID:	FBgn0040350	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_060890.2	Gene:	SLC22A15 / 55356	HGNCID:	20301	Length:	547	Species:	Homo sapiens

Alignment Length:	477	Identity:	99/477 - (20%)
Similarity:	175/477 - (36%)	Gaps:	131/477 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 YAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVL 156
            ::|:....:.:|.|:|..||:.:.:.|:|.|.:..:....|.|.....|.::|.|....|...|.
Human   119 FSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVA 183

  Fly   157 MTYLTELHGRKHRQRIMMMVGIMFSIATLTLPGLAMLILPETWNIQIWTLSLTSWQFFVAVTALP 221
            ...|.|..|..:......:.|:.|::      |:|...|...:        :.||:....:..|.
Human   184 FVLLNECVGTAYWALAGSIGGLFFAV------GIAQYALLGYF--------IRSWRTLAILVNLQ 234

  Fly   222 SLLSFVLFFFFPESPKFLMSKGRNREALDAFKFMYHLNSRKPKDSFPIKLLANEVIVPVKKHAKD 286
            ..:.|:|..|.||||::|.|:||..||.:|. ::....:||.|.:|.:...||.
Human   235 GTVVFLLSLFIPESPRWLYSQGRLSEAEEAL-YLIAKRNRKLKCTFSLTHPANR----------- 287

  Fly   287 ETIPTELKLPTECVEVQDPENQDSKKSSLRSGFTQLRPLFTKPYLGLSLWVYLLNFCVLLGQNTM 351
                       .|.|                         |..:|.|..:..||...::|    |
Human   288 -----------SCRE-------------------------TGSFLDLFRYRVLLGHTLIL----M 312

  Fly   352 RLWLPQLFASINEYENLMSGESQSTSICNILEYSVNRTQSQLEAVTRNDPTVECHVIITPSTYTN 416
            .:|.                      :|:::.|.:..:...|..                |.|.|
Human   313 FIWF----------------------VCSLVYYGLTLSAGDLGG----------------SIYAN 339

  Fly   417 NLIVAGAGFV---AYMLAGFLVN--LVGVKLIMTSGLLIAA-GCSIGMYWSSSAASTVALASLFV 475
               :|.:|.:   :|.|..:|:|  ..|.|..:::.|.:.. .|.|.|:......:.|     |.
Human   340 ---LALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGV-----FA 396

  Fly   476 TMGSISATSV----ISASVS--------LFPTSLRTMIVSLEMMFGRLGSLLGNIFFPALMGLGC 528
            .:.|.|.:.:    |||:.:        |:||.:|.:.:....||.|:|.::.. |.|:|..:..
Human   397 VVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAP-FIPSLKYVQW 460

  Fly   529 VPPFLMISAFMLAGCFMAAFLP 550
            ..||::..|..|....::..||
Human   461 SLPFIVFGATGLTSGLLSLLLP 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3690	NP_001284764.1	SP	42..549	CDD:273317	97/474 (20%)
		MFS	49..>195	CDD:119392	23/102 (23%)
		MFS	419..>550	CDD:119392	34/148 (23%)
SLC22A15	NP_060890.2	MFS	111..469	CDD:119392	95/462 (21%)
		MFS_1	111..450	CDD:284993	90/442 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	522..547
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153557
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840