DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3690 and Slc22a6

DIOPT Version :9

Sequence 1:	NP_001284764.1	Gene:	CG3690 / 31047	FlyBaseID:	FBgn0040350	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_058920.1	Gene:	Slc22a6 / 29509	RGDID:	69338	Length:	551	Species:	Rattus norvegicus

Alignment Length:	518	Identity:	110/518 - (21%)
Similarity:	197/518 - (38%)	Gaps:	137/518 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 PAAMGTVYETSTMSYILPS---AECDLKLS-LLDKGILNAITYAGMISSAVLWGYLADIKGRRNL 114
            |...|.||:.||    .||   .|.:|..| ...:.:..::...|::..|:::|||||..|||.:
  Rat   104 PCIDGWVYDNST----FPSTIVTEWNLVCSHRAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRKV 164

  Fly   115 LIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTE---LHGRKHRQRIMMMV 176
            ||:.|....:.....|.:.:.....||:.|.|..::......||...|   :|.|.:   :..::
  Rat   165 LILNYLQTAVSGTCAAYAPNYTVYCVFRLLSGMSLASIAINCMTLNVEWMPIHTRAY---VGTLI 226

  Fly   177 GIMFSIATLTLPGLAMLILPETWNIQIWTLSLTSWQFFVAVTALPSLLSFVLFFFFPESPKFLMS 241
            |.::|:....|.|:|              .::..|:....|.::|..::|:..:||.||.::..|
  Rat   227 GYVYSLGQFLLAGIA--------------YAVPHWRHLQLVVSVPFFIAFIYSWFFIESARWYSS 277

  Fly   242 KGRNREALDAFKFMYHLNSRKPKDSFPIKLLANEVIVPVKKHAKDETIPTELKLPTECVEVQDPE 306
            .||....|.|.:.:..:|.::.:.:    .|:.||:        ..::..||.|         .:
  Rat   278 SGRLDLTLRALQRVARINGKQEEGA----KLSIEVL--------RTSLQKELTL---------SK 321

  Fly   307 NQDSKKSSLRSGFTQLRPLFTKPYLGLSLWVYLLNFCVLLGQNTMRLWLPQLFASINEYENL--- 368
            .|.|....||.  ..||.||    |.||:                 ||....||    |..|
  Rat   322 GQASAMELLRC--PTLRHLF----LCLSM-----------------LWFATSFA----YYGLVMD 359

  Fly   369 MSGESQSTSICNILEYSVNRTQSQLEAVTRNDPTVECHVIITPSTYTNNLIVAGAGFVAYMLAGF 433
            :.|...|..:..::..:|:.....:           |.::|      |::....|...:.:|||.
  Rat   360 LQGFGVSMYLIQVIFGAVDLPAKFV-----------CFLVI------NSMGRRPAQMASLLLAGI 407

  Fly   434 LVNLVGV-----KLIMTSGLLIAAGCSIGMYWSSSAASTVALASLFVTMGSISATSVISASVSLF 493
            .:.:.|:     .:|.||..::..||               |||.|        ..:...:..|:
  Rat   408 CILVNGIIPKSHTIIRTSLAVLGKGC---------------LASSF--------NCIFLYTGELY 449

  Fly   494 PTSLRTMIVSLEMMFGRLGSLLGNI------FFPALMGLGCVPPFLMISAFMLAGCFMAAFLP 550
            ||.:|...:.:.....|:||::..:      |:|::       |..:..|..:....:.|.||
  Rat   450 PTVIRQTGLGMGSTMARVGSIVSPLVSMTAEFYPSM-------PLFIFGAVPVVASAVTALLP 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3690	NP_001284764.1	SP	42..549	CDD:273317	108/515 (21%)
		MFS	49..>195	CDD:119392	39/147 (27%)
		MFS	419..>550	CDD:119392	26/141 (18%)
Slc22a6	NP_058920.1	2A0119	11..515	CDD:273328	110/518 (21%)
		MFS	135..505	CDD:119392	97/481 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..551
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347181
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840