DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3690 and Slc22a15

DIOPT Version :9

Sequence 1:	NP_001284764.1	Gene:	CG3690 / 31047	FlyBaseID:	FBgn0040350	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_001034460.2	Gene:	Slc22a15 / 242126	MGIID:	3607704	Length:	544	Species:	Mus musculus

Alignment Length:	479	Identity:	100/479 - (20%)
Similarity:	172/479 - (35%)	Gaps:	135/479 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 YAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVL 156
            ::|:....:.:|.|:|..|||.:.:.|:|.|.:..:....|.|.....|.::|.|....|...|.
Mouse   119 FSGVFVGVISFGQLSDRFGRRKVYLTGFALDILFAVANGFSPSYEFFAVTRFLVGMMNGGMSLVA 183

  Fly   157 MTYLTELHGRKHRQRIMMMVGIMFSIATLTLPGLAMLILPETWNIQIWTLSLTSWQFFVAVTALP 221
            ...|.|..|..:......:.|:.|::      |:|...|...:        :.||:....:..|.
Mouse   184 FVLLNECVGTAYWALAGSIGGLFFAV------GIAQYALLGYF--------IRSWRTLAVLVNLQ 234

  Fly   222 SLLSFVLFFFFPESPKFLMSKGRNREALDAFKFMYHLNSRKPKDSFPIKLLANEVIVPVKKHAKD 286
            ..|.|:|..|.||||::|.|:||..||.:|..|:...| ||.|.:|.:...||
Mouse   235 GTLVFLLSLFIPESPRWLYSQGRLSEAEEALYFIAKRN-RKLKCTFSLTHPAN------------ 286

  Fly   287 ETIPTELKLPTECVEVQDPENQDSKKSSLRSGFTQLRPLFTKPYLGLSLWVYLLNFCVLLGQN-- 349
                                                     :.|.....::.|..:.:|||..
Mouse   287 -----------------------------------------RSYRATGSFLDLFRYRILLGHTLI 310

  Fly   350 TMRLWLPQLFASINEYENLMSGESQSTSICNILEYSVNRTQSQLEAVTRNDPTVECHVIITPSTY 414
            .|.:|.                      :|:::.|.:..:...|..                |.|
Mouse   311 LMFIWF----------------------VCSLVYYGLTLSAGDLGG----------------SIY 337

  Fly   415 TNNLIVAGAGFV---AYMLAGFLVN--LVGVKLIMTSGLLIAA-GCSIGMYWSSSAASTVALASL 473
            .|   :|.:|.:   :|.|..:|:|  ..|.|..:.:.|.:.. .|.|.|:......:.|
Mouse   338 AN---LALSGLIEIPSYPLCIYLINQRWFGRKRTLAAFLCLGGLACLIVMFLPEKKDTGV----- 394

  Fly   474 FVTMGSISATSV----ISASVS--------LFPTSLRTMIVSLEMMFGRLGSLLGNIFFPALMGL 526
            |..:.|.|.:.:    |||:.:        |:||.:|.:.:....||.|:|.::.. |.|:|..:
Mouse   395 FAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGACSMFSRVGGIIAP-FVPSLKEV 458

  Fly   527 GCVPPFLMISAFMLAGCFMAAFLP 550
            ....||::..|..|....::..||
Mouse   459 QWSLPFIVFGATGLTSGLLSLLLP 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3690	NP_001284764.1	SP	42..549	CDD:273317	98/476 (21%)
		MFS	49..>195	CDD:119392	24/102 (24%)
		MFS	419..>550	CDD:119392	34/148 (23%)
Slc22a15	NP_001034460.2	MFS	121..469	CDD:119392	96/462 (21%)
Slc22a15	NP_001034460.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..544
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843711
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840