DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3690 and Slc22a8

DIOPT Version :9

Sequence 1:	NP_001284764.1	Gene:	CG3690 / 31047	FlyBaseID:	FBgn0040350	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_001158106.1	Gene:	Slc22a8 / 19879	MGIID:	1336187	Length:	537	Species:	Mus musculus

Alignment Length:	524	Identity:	117/524 - (22%)
Similarity:	190/524 - (36%)	Gaps:	147/524 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 AAVPAAMGTVYETSTMSYILPSAECDL-----KLSLLDKGILNAITYAGMISSAVLWGYLADIKG 110
            |..|...|.:| .||...|:  .|.||     ||    |.:..::..||::....::|.|:|..|
Mouse    91 ATEPCLDGWIY-NSTRDTIV--TEWDLVCGSNKL----KEMAQSVFMAGILVGGPVFGELSDRFG 148

  Fly   111 RRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIMMM 175
            |:.:|...|..........|.|.|....|:|::|.|..:||.....:....|......|......
Mouse   149 RKPILTWSYLLLAASGSSAAFSPSLTVYMIFRFLCGCSISGISLSTIILNVEWVPTSTRAISSTT 213

  Fly   176 VGIMFSIATLTLPGLAMLILPETWNIQIWTLSLTSWQFFVAVTALPSLLSFVLFFFFPESPKFLM 240
            :|..::|....|||||..: |: |.   |.....|..||:.     ||||    ::.|||.::|:
Mouse   214 IGYCYTIGQFILPGLAYAV-PQ-WR---WLQLSVSAAFFIF-----SLLS----WWVPESIRWLV 264

  Fly   241 SKGRNREALDAFKFMYHLNSRKPKDSFPIKLLANEVIVPVKKHAKDETIPTELKLPTECVEVQDP 305
            ..|:..:||...:.:...|.:|.:..   ||...|:...::|
Mouse   265 LSGKFSKALKTLQRVATFNGKKEEGE---KLTVEELKFNLQK----------------------- 303

  Fly   306 ENQDSKKSSLRSGFTQLRPLFTKPYLGLSLWVYLLNFCVLLGQNTMRLWLPQLFASINEYENLMS 370
               |...:.::.|.:.|        ..:|: :..:.||:.|.      |....||    |.:|..
Mouse   304 ---DITSAKVKYGLSDL--------FRVSI-LRRVTFCLSLA------WFATGFA----YYSLAM 346

  Fly   371 GESQSTSICNILEYSVNRTQSQLEAVTRNDPTVECHVIITPSTYTNNLIVAGAGFVAYMLAGFLV 435
            |         :.|:.||                         .|...:|..|....|..:....:
Mouse   347 G---------VEEFGVN-------------------------IYILQIIFGGVDIPAKFITILSI 377

  Fly   436 NLVGVKLIMTSG-LLIAAGCSIGMYWSSSAASTVALASLFV--------TMGSISATSVISASVS 491
            :.:|.::  |.| |||.||.:|             ||.:||        |..::.....:|.|.|
Mouse   378 SYLGRRI--TQGFLLILAGVAI-------------LALIFVSSEMQLLRTALAVFGKGCLSGSFS 427

  Fly   492 --------LFPTSLRTMIVSLEMMFGRLGSLLGNIFFPALMGLGCVPPFL---MISAFMLAGCFM 545
                    |:||.||...:.:..::.|:||::.    |.:...|.:.||:   :.....|.|...
Mouse   428 CLFLYTSELYPTVLRQTGMGISNIWARVGSMIA----PLVKITGELQPFIPNVIFGTMTLLGGSA 488

  Fly   546 AAFL 549
            |.||
Mouse   489 AFFL 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3690	NP_001284764.1	SP	42..549	CDD:273317	115/522 (22%)
		MFS	49..>195	CDD:119392	40/148 (27%)
		MFS	419..>550	CDD:119392	37/151 (25%)
Slc22a8	NP_001158106.1	2A0119	11..503	CDD:273328	117/524 (22%)
Slc22a8	NP_001158106.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..537
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843753
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840