DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3690 and Slc22a6

DIOPT Version :9

Sequence 1:	NP_001284764.1	Gene:	CG3690 / 31047	FlyBaseID:	FBgn0040350	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_032792.2	Gene:	Slc22a6 / 18399	MGIID:	892001	Length:	545	Species:	Mus musculus

Alignment Length:	516	Identity:	103/516 - (19%)
Similarity:	197/516 - (38%)	Gaps:	133/516 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 PAAMGTVYETSTMSYILPS---AECDLKLS-LLDKGILNAITYAGMISSAVLWGYLADIKGRRNL 114
            |...|.||:.||    .||   .|.:|..| ...:.:..::...|::..|:::|||||..|||.:
Mouse    98 PCLDGWVYDNST----FPSTIVTEWNLVCSHRAFRQLAQSLFMVGVLLGAMMFGYLADRLGRRKV 158

  Fly   115 LIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTE---LHGRKHRQRIMMMV 176
            ||:.|....:.....|.:.:.....:|:.|.|..::......||...|   :|.|.:   :..::
Mouse   159 LILNYLQTAVSGTCAAYAPNYTVYCIFRLLSGMSLASIAINCMTLNMEWMPIHTRAY---VGTLI 220

  Fly   177 GIMFSIATLTLPGLAMLILPETWNIQIWTLSLTSWQFFVAVTALPSLLSFVLFFFFPESPKFLMS 241
            |.::|:....|.|:|              .::..|:......::|..::|:..:||.||.::..|
Mouse   221 GYVYSLGQFLLAGIA--------------YAVPHWRHLQLAVSVPFFVAFIYSWFFIESARWYSS 271

  Fly   242 KGRNREALDAFKFMYHLNSRKPKDSFPIKLLANEVIVPVKKHAKDETIPTELKLPTECVEVQDPE 306
            .||....|.|.:.:..:|.::.:.:    .|:.||:        ..::..||.|         .:
Mouse   272 SGRLDLTLRALQRVARINGKQEEGA----KLSIEVL--------QTSLQKELTL---------NK 315

  Fly   307 NQDSKKSSLRSGFTQLRPLFTKPYLGLSLWVYLLNFCV------LLGQNTMRLWLPQLFASINEY 365
            .|.|....||.      |...:.:|.||:..:..:|..      |.|.......:..:|.::
Mouse   316 GQASAMELLRC------PTLRRLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAV--- 371

  Fly   366 ENLMSGESQSTSICNILEYSVNRTQSQLEAVTRNDPTVECHVIITPSTYTNNLIVAGAGFVAYML 430
                  :..:..:|.::..|:.|..:||.                      :|::||   :..::
Mouse   372 ------DLPAKFVCFLVINSMGRRPAQLA----------------------SLLLAG---ICILV 405

  Fly   431 AGFLVNLVGVKLIMTSGLLIAAGCSIGMYWSSSAASTVALASLFVTMGSISATSVISASVSLFPT 495
            .|.:..  |..:|.||..::..||               |||.|        ..:...:..|:||
Mouse   406 NGIIPR--GHTIIRTSLAVLGKGC---------------LASSF--------NCIFLYTGELYPT 445

  Fly   496 SLRTMIVSLEMMFGRLGSLLGNI------FFPALMGLGCVPPFLMISAFMLAGCFMAAFLP 550
            .:|...:.:.....|:||::..:      |:|::       |..:..|..:|...:.|.||
Mouse   446 MIRQTGLGMGSTMARVGSIVSPLISMTAEFYPSI-------PLFIFGAVPVAASAVTALLP 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3690	NP_001284764.1	SP	42..549	CDD:273317	101/513 (20%)
		MFS	49..>195	CDD:119392	38/147 (26%)
		MFS	419..>550	CDD:119392	26/136 (19%)
Slc22a6	NP_032792.2	2A0119	11..509	CDD:273328	103/516 (20%)
		MFS	129..499	CDD:119392	90/479 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..545
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843756
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930