DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3699 and HSDL2

DIOPT Version :9

Sequence 1:	NP_569875.2	Gene:	CG3699 / 31046	FlyBaseID:	FBgn0040349	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_115679.2	Gene:	HSDL2 / 84263	HGNCID:	18572	Length:	418	Species:	Homo sapiens

Alignment Length:	311	Identity:	80/311 - (25%)
Similarity:	128/311 - (41%)	Gaps:	76/311 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LSNKVVIVTGASSGIGAAIAQVLAREGATLALVGRN--------------VANLEATKKSLKGTQ 53
            |:...|.:||||.|||.|||...|::||.:.:..:.              ...:||.     |.:
Human     8 LAGCTVFITGASRGIGKAIALKAAKDGANIVIAAKTAQPHPKLLGTIYTAAEEIEAV-----GGK 67

  Fly    54 AEIVVADV--TKDADAIVQQTLAKFGRIDVLVNNAGILGKGGLIDLDIEEFDAVLNTNLRGVILL 116
            |...:.||  .:...|.|::.:.|||.||:|||||..:.....:|...:..|.::|.|.||..|.
Human    68 ALPCIVDVRDEQQISAAVEKAIKKFGGIDILVNNASAISLTNTLDTPTKRLDLMMNVNTRGTYLA 132

  Fly   117 TKAVLPHLLKTKGA-VVNVSSCAGIRP--FAGALSYGVSKAALDQFTKIVALEMAPQGVRVNSVN 178
            :||.:|:|.|:|.| ::|:|....:.|  |....:|.::|..:..:...:|.|...: :.||::.
Human   133 SKACIPYLKKSKVAHILNISPPLNLNPVWFKQHCAYTIAKYGMSMYVLGMAEEFKGE-IAVNALW 196

  Fly   179 PGFVVTNIH----------------RNIGIVDEEYNGMLQR------------------------ 203
            |   .|.||                |.:.|:.:....:.|:
Human   197 P---KTAIHTAAMDMLGGPGIESQCRKVDIIADAAYSIFQKPKSFTGNFVIDENILKEEGIENFD 258

  Fly   204 --AIN-SHPMGRVGDVTEVAEAVAFLASSKASFTTGALFPIDGGKHNLTPR 251
              ||. .||:.....:.|..|||     ||...:|||:......|..|.|:
Human   259 VYAIKPGHPLQPDFFLDEYPEAV-----SKKVESTGAVPEFKEEKLQLQPK 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3699	NP_569875.2	fabG	1..244	CDD:235546	77/302 (25%)
CG3699	NP_569875.2	NADB_Rossmann	3..248	CDD:304358	78/306 (25%)
HSDL2	NP_115679.2	HSDL2_SDR_c	8..248	CDD:187663	64/248 (26%)
HSDL2	NP_115679.2	SCP2	319..412	CDD:376720
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0725
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810