DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3703 and CG12241

DIOPT Version :9

Sequence 1:	NP_569874.1	Gene:	CG3703 / 31045	FlyBaseID:	FBgn0040348	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster

Alignment Length:	873	Identity:	166/873 - (19%)
Similarity:	295/873 - (33%)	Gaps:	303/873 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EMKMAEAQETKDSCSTIEG--QLPAGPVRAEDEEEEVEVEQEQQELLSERWSPLGANYDDANSAS 64
            |..:.|.....:..|..:|  ..|.||..|      :......||:|::    ||...:.|:..:
  Fly    31 EDDLGELPPMMEELSVADGLRPNPGGPFSA------LTASMWPQEILAK----LGGGAELASGPN 85

  Fly    65 S---------GVDCELEPGLEKSEARRGSTGSELARLRSIEEEQELLTSSLLALTSHFAHVQL-R 119
            .         |...|.|.|.|:|       .::|..:..:|:.|:.|        ...||::. .
  Fly    86 DQPEYRFDEFGFRVEEEDGPEQS-------SNKLLSIPFVEDAQQRL--------QWIAHLEFSH 135

  Fly   120 VRQIVEAPAEERDQLL---RDLEDFAFQGIPDAV----------------QSKESHPD--KPASD 163
            .::..|...|..|.:|   ..|.:...||||..:                :|:.|:.|  |.:|:
  Fly   136 NKEAAELSWEHVDVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKSETSYHDIVKASSN 200

  Fly   164 G--------EKD-----------HGPDSQLIQQLKSQLTEL----EQIAYEAGEPGILPQHVLL- 204
            .        |||           ..|:...|.:|:..|..:    ..|.|..| .|::...:||
  Fly   201 DQLMTSKQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQG-TGVIVACLLLF 264

  Fly   205 --EKQKF-----ILDEL-------RAKLNLQVEQ---HELPA--LST--EQLR-HQVDNAI---- 243
              |:..|     |:::|       ...|.:|.:|   |.|.|  ||:  |.|| |.::.::
  Fly   265 MEEENAFWMMATIVEDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVDESLRKHDIELSLITLH 329

  Fly   244 -------------------------GEFV------GPLKMKEQLVAQLKT-------------QI 264
                                     |..|      |.||:|||.:..|:.             ::
  Fly   330 WFLTLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKEQDLKHLENSAQIFNSLSDIPGEV 394

  Fly   265 TDLERFIAFLQCDAIEGSVGDRLKLLSGAYNSYAAKQTARSSQASYVATNAPATTATTPPSSGLG 329
            ||:|  :.|.|...:.||:            |.....|.|....:|:..:         ....:|
  Fly   395 TDVE--VLFRQALEVGGSL------------SQTVIDTHRRRHLAYLMAD---------QGHQIG 436

  Fly   330 AHSSGESLHSK--AHGLLDKASVLMQMFASTHLVK--PRTHDEFQQNSLKKTH-----------K 379
            ...:..:|..:  |...:.|:..:::.|    |.:  ....|:.:..::::|.           .
  Fly   437 NPEAAPNLPKQQLARRQVRKSKSILEAF----LFRGDGNEGDQLKNKNIRQTEILVDLREAILKV 497

  Fly   380 GNHWGDLRAQLEVDIQEVAALAATLSC-----DREKLANIKRALRKQQQQA-------ESTEFSD 432
            |.|:..:..:|...||    |.|..|.     |.|...|:.|. ||::.:|       :..|...
  Fly   498 GRHFITIEPKLAGHIQ----LTANYSTESHAKDHENFINVART-RKRRAKALHDFERHDDDELGF 557

  Fly   433 TGNPVINSQNGALTLPPRCRRAVPTGHELAPYASGGAISSDSDEDISYSNFEWEKE--------- 488
            ..|.:|                              .|.|..||..      |..|
  Fly   558 RRNDII------------------------------TIISQKDEHC------WVGELNGLRGWFP 586

  Fly   489 --------SKSRRTTHARGDSIATIGRELTTVVRKNFARTLQQLIQHGLRIPAESAASSLMVPFM 545
                    .:|:..|.|..|:|:   ..:|.:||...|..::..::||::.|.
  Fly   587 AKFVELLDERSKLYTSAGDDAIS---ETVTDLVRGTLAPAIKAFLEHGMKRPT------------ 636

  Fly   546 RCLHPGPPVVPPAVGGDSQFLGLGRAMHAWELVLAYYRLKHGEEYNNTPAR-KLSQSFQLDIVDA 609
                                 .||..:|.|..:......:..:::.:..:| .|.::::|| .|.
  Fly   637 ---------------------FLGGPIHPWLYIEEAATREVEKDFESVYSRLVLCKTYRLD-EDG 679

  Fly   610 QAVTAKQSLLSAVGMILAMHRPYKRSNNAHFKAFVCAGLNSHLLVEWLNLILSCHELVDTYYSAD 674
            :.:|.::.|...|..|...|.......:...::.:|.|||..:|..||.::.:|.|:|..:|.:.
  Fly   680 KVLTPEELLYRCVQAINQTHDDAHAQMDVKLRSLICLGLNEQVLHLWLEVLCACQEVVQKWYHSW 744

  Fly   675 SYVARTGFRDSLRSIDALSRFDFDLPVD 702
            |::...|:......:..||:|.|:|..|
  Fly   745 SFIDSPGWVQIKCELRILSQFAFNLNPD 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3703	NP_569874.1	RUN	516..703	CDD:280855	37/188 (20%)
CG12241	NP_650432.1	TBC	161..375	CDD:214540	46/214 (21%)
		SH3_SGSM3	540..592	CDD:212747	10/87 (11%)
		RUN	619..773	CDD:280855	37/188 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010