Protein Alignment mus81 and MUS81

DIOPT Version :9

• Sequence 1: NP_569873.1
• Gene: mus81 / 31044
• FlyBaseID: FBgn0040347
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_001337212.1
• Gene: MUS81 / 80198
• HGNCID: 29814
• Length: 552
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 178/542 - (32%)
• Similarity: 258/542 - (47%)
• Gaps: 139/542 - (25%)

  Fly    12 PNPLFTRWLERWLREAERREQKSQFSLRQALESLKSYPLPLASGRDCSILRGFGGTLCQLIDEEL 76
            |||||.|||..|..||.|..::::|..::||.||:.|||||.||::..||:.||..||:::||.|
Human    17 PNPLFVRWLTEWRDEATRSRRRTRFVFQKALRSLRRYPLPLRSGKEAKILQHFGDGLCRMLDERL 81

  Fly    77 RHHR------------------------------------------------------------- 80
            :.||
Human    82 QRHRTSGGDHAPDSPSGENSPAPQGRLAEVQDSSMPVPAQPKAGGSGSYWPARHSGARVILLVLY 146

  Fly    81 -------GLQLLPQEAVVQERYEQQVQAVVRKVQE----KQLEHQKRQNKCDRPRK--LTKKDL- 131
                   |...|.:|.::|...::..:......:.    :.|.|:....:..:|.:  ||.:.|
Human   147 REHLNPNGHHFLTKEELLQRCAQKSPRVAPGSARPWPALRSLLHRNLVLRTHQPARYSLTPEGLE 211

  Fly   132 -----------------------------------AELAA-LEERERVVRMKPGQFQLLLLVDTQ 160
                                               ||||: ...:::.:.::||::::||.||..
Human   212 LAQKLAESEGLSLLNVGIGPKEPPGEETAVPGAASAELASEAGVQQQPLELRPGEYRVLLCVDIG 276

  Fly   161 ETSGKNKRVLDQTRSYLESLGARHEVRRLTIGDFLWVAQ-----DQEGN--ELVLPYIVERKRMD 218
            ||.|...|  .:....|:.|...|.||:|.:|||:||||     |...|  ||||.:||||||:|
Human   277 ETRGGGHR--PELLRELQRLHVTHTVRKLHVGDFVWVAQETNPRDPAANPGELVLDHIVERKRLD 339

  Fly   219 DLASSIRDGRFHEQKHRLQHCGLQHIIYLVEDYGDNEQLGLPLDSLQQALTNAKVQTGVRVVRTA 283
            ||.|||.||||.|||.||:.|||:..:||||::|....|.||..:|.||:||.:|..|..|.|||
Human   340 DLCSSIIDGRFREQKFRLKRCGLERRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTA 404

  Fly   284 NHYRSMSYLAGMSRTLGQIFAGKKLHS--------VDRGAIDQST--C-LLTHSDLGLLKFRALY 337
            :...|.:|||.::|.|.:::.|..|.|        .:.||:....  | |||.||     |.|
Human   405 DIKESAAYLALLTRGLQRLYQGHTLRSRPWGTPGNPESGAMTSPNPLCSLLTFSD-----FNA-- 462

  Fly   338 EDSAKNAQLTVREVFVQQLLQLHSLSLERAMAIVERYPTPRWLLDAYAECADQKQARLLLASIPC 402
             .:.||...:|||||.:||:|:..:|.|:|.|:|:||.||..||.||..||..|:...||::|.|
Human   463 -GAIKNKAQSVREVFARQLMQVRGVSGEKAAALVDRYSTPASLLAAYDACATPKEQETLLSTIKC 526

  Fly   403 GPLERPLGDKISQCLHEFYSTH 424
            |.|:|.||..:|:.|.:.|.::
Human   527 GRLQRNLGPALSRTLSQLYCSY 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mus81	NP_569873.1	NT_Pol-beta-like	16..>96	CDD:299849	35/147 (24%)
		ERCC4	157..295	CDD:280828	72/144 (50%)
MUS81	NP_001337212.1	HHH_8	<43..79	CDD:317159	17/35 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	84..130		2/45 (4%)
		Interaction with BLM. /evidence=ECO:0000269|PubMed:15805243	125..244		10/118 (8%)
		ERCC4	273..416	CDD:308387	72/144 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149718
Domainoid	1	1.000	117	1.000	Domainoid score	I5927
eggNOG	1	0.900	-	-		E1_COG1948
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5725
Inparanoid	1	1.050	288	1.000	Inparanoid score	I2832
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52011
OrthoDB	1	1.010	-	-		D470169at33208
OrthoFinder	1	1.000	-	-		FOG0003734
OrthoInspector	1	1.000	-	-		oto90234
orthoMCL	1	0.900	-	-		OOG6_103117
Panther	1	1.100	-	-	LDO	PTHR13451
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R782
SonicParanoid	1	1.000	-	-		X2590
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800