Protein Alignment mus81 and Mus81

DIOPT Version :10

• Sequence 1: NP_569873.1
• Gene: mus81 / 31044
• FlyBaseID: FBgn0040347
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_082153.3
• Gene: Mus81 / 71711
• MGIID: 1918961
• Length: 551
• Species: Mus musculus
• Alignment Length: 534
• Identity: 178/534 - (33%)
• Similarity: 258/534 - (48%)
• Gaps: 124/534 - (23%)

  Fly    12 PNPLFTRWLERWLREAERREQKSQFSLRQALESLKSYPLPLASGRDCSILRGFGGTLCQLIDEEL 76
            |||||.|||..|..||..|.:.::|..::||.||:.|||||.||::..||:.||..||:::||:|
Mouse    17 PNPLFVRWLTEWRDEAASRGRHTRFVFQKALRSLQRYPLPLRSGKEAKILQHFGDRLCRMLDEKL 81

  Fly    77 RHH---------------RGLQLLPQEAV-------------------------------VQERY 95
            :.|               :|....|.|.|                               :.:.|
Mouse    82 KQHLASGGDHAPSSPSGKKGASKGPPEQVQDSSMPVPTQPQAGSTSVGYWPAQNSGAREILLQLY 146

  Fly    96 EQQV----------QAVVRKVQEK----------------QLEHQKRQNKCDRPRK--LTKKDLA 132
            .:.:          :.:::|..:|                .|.|:.......||.:  ||.:.|
Mouse   147 REHLNSDGHSFLTKEELLQKCAQKTPRVVPGSSKPWPALRSLLHRNLILGTHRPARYALTPEGL- 210

  Fly   133 ELA------------------------------ALEE--------RERVVRMKPGQFQLLLLVDT 159
            |||                              ||.|        ::|.:.::|.::::||.||.
Mouse   211 ELAQKLAEAEGLSTRHAGFRPEEHHGEDSAVPEALSEPGTTEGAVQQRPLELRPSEYRVLLCVDI 275

  Fly   160 QETSGKNKRVLDQTRSYLESLGARHEVRRLTIGDFLWVAQD------QEGNELVLPYIVERKRMD 218
            .||.|...|  .:....|:.|...|.||:|.:|||:||||:      :...||||.:||||||:|
Mouse   276 GETRGAGHR--PEMLRELQRLRVPHTVRKLHVGDFVWVAQETRPRDPERPGELVLDHIVERKRLD 338

  Fly   219 DLASSIRDGRFHEQKHRLQHCGLQHIIYLVEDYGDNEQLGLPLDSLQQALTNAKVQTGVRVVRTA 283
            ||.|||.||||.|||.||:.|||.|.:||||::|....|.||..:|.||:||.:|..|..|.||.
Mouse   339 DLCSSIIDGRFREQKFRLKRCGLGHRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTM 403

  Fly   284 NHYRSMSYLAGMSRTLGQIFAGKKLHSVD---RGAIDQSTCLLTHSDLGLLKFRALYEDSAKNAQ 345
            :...|..|||.:::.|.:::.|..|.|..   .||.:......|:....||.|.....::.||..
Mouse   404 DIKESAGYLALLTKGLERLYQGHTLRSRPWGAPGAAESEAKPSTNPLCSLLTFSDFNAEAVKNKA 468

  Fly   346 LTVREVFVQQLLQLHSLSLERAMAIVERYPTPRWLLDAYAECADQKQARLLLASIPCGPLERPLG 410
            .:|||||.:||:|:..||.|:|.|:|:||.||..||.||..||..|:..:||::|.||.|:|.||
Mouse   469 QSVREVFARQLMQVRGLSGEKAAAVVDRYSTPASLLAAYDACATAKEQEMLLSTIKCGRLQRNLG 533

  Fly   411 DKISQCLHEFYSTH 424
            ..:|:.|::.|.:|
Mouse   534 PALSRTLYQLYCSH 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mus81	NP_569873.1	NT_Pol-beta-like	16..>96	CDD:472251	34/125 (27%)
		XPF_nuclease_Mus81	150..299	CDD:410850	72/154 (47%)
Mus81	NP_082153.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	84..131		5/46 (11%)
		Interaction with BLM. /evidence=ECO:0000250|UniProtKB:Q96NY9	124..244		13/120 (11%)
		WH_MUS81	130..219	CDD:411029	13/89 (15%)
		Winged helix domain (WHD), critical for endonuclease activity. /evidence=ECO:0000250|UniProtKB:Q96NY9	131..230		13/99 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	229..259		3/29 (10%)
		XPF_nuclease_Mus81	266..419	CDD:410850	72/154 (47%)
		Helix-hairpin-helix (2HhH), involved in DNA recognition and bending. /evidence=ECO:0000250|UniProtKB:Q96NY9	471..545		36/73 (49%)