DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mus81 and FANCM

DIOPT Version :9

Sequence 1:	NP_569873.1	Gene:	mus81 / 31044	FlyBaseID:	FBgn0040347	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	XP_011535336.1	Gene:	FANCM / 57697	HGNCID:	23168	Length:	2053	Species:	Homo sapiens

Alignment Length:	474	Identity:	94/474 - (19%)
Similarity:	173/474 - (36%)	Gaps:	139/474 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 REPNPLFTRWLERWLREAERREQKSQFSLRQALESLKSYPLPLASGRDCSILRGF-GGTLCQLID 73
            |..:.|:.|:||  ::|.    ..:.:...|||       :|    ||.|  :.| .||:....:
Human  1254 RPLDDLYGRYLE--IKEI----SDANYVSNQAL-------IP----RDHS--KNFTSGTVIIPSN 1299

  Fly    74 EELRH----HRGLQLLPQEAVVQERYEQQVQAVVRKVQEKQLEHQKRQNKCDRPRKLTKKDLAEL 134
            |::::    |..|.....|.::...|.|....|.:||....|   .:.|..:...|:.|:.|...
Human  1300 EDMQNPNYVHLPLSAAKNEELLSPGYSQFSLPVQKKVMSTPL---SKSNTLNSFSKIRKEILKTP 1361

  Fly   135 AALEERERVVRMKP--------GQFQLLLLVDTQETSG-----------KNKRVLDQTRSYLESL 180
            .:.:|:..:.|.|.        .:|.|    :..::||           ::.::|....|..:.:
Human  1362 DSSKEKVNLQRFKEALNSTFDYSEFSL----EKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEI 1422

  Fly   181 GARHEVRRLTIGDFLWVAQDQEGNELVLPYIVERKR----------MDDLASSIRDGRFHEQKHR 235
             .|.:|:|.. |:.|...:||:.:|:..|....:||          ..:|:||.....|.:...:
Human  1423 -FRRKVKRAK-GNVLNSPEDQKNSEVDSPLHAVKKRRFPINRVSKYQSELSSSDESENFPKPCSQ 1485

  Fly   236 LQH---CG---------------LQHII----------------YLVEDYGD---NEQLGLPLD- 262
            |:.   |.               |:|:.                |:..|..|   |||....||
Human  1486 LEDFKVCNGNARRGIKVPKRQSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDF 1550

  Fly   263 -----SLQQALTNAKVQT----GVRVVRTANHYRSMSYLAGMSRTLGQIFAGKKLHSVDRGAIDQ 318
                 .|.||:.:::::.    .:|.....|.|:.      :.:|...|....::...|...::.
Human  1551 LNDETQLSQAINDSEMRAIYMKSLRSPMMNNKYKM------IHKTHKNINIFSQIPEQDETYLED 1609

  Fly   319 STCLLTHSDLGLLKFRALYEDSAKNAQLTVREVFVQQLLQLHSLSLERAMAIVERYPTPR-WLLD 382
            |.|              :.|:.:...|.:..||.|.     .:|..:...|..::|.|.| .:|.
Human  1610 SFC--------------VDEEESCKGQSSEEEVCVD-----FNLITDDCFANSKKYKTRRAVMLK 1655

  Fly   383 AYAE--CADQKQ--ARLLL 397
            ...|  ||..|:  :|::|
Human  1656 EMMEQNCAHSKKKLSRIIL 1674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mus81	NP_569873.1	NT_Pol-beta-like	16..>96	CDD:299849	18/84 (21%)
mus81	NP_569873.1	ERCC4	157..295	CDD:280828	37/205 (18%)
FANCM	XP_011535336.1	MPH1	83..617	CDD:224036
		DEXDc	106..248	CDD:238005
		FANCM_ID	298..413	CDD:277190
		HELICc	439..589	CDD:238034
		FANCM-MHF_bd	675..789	CDD:293388
		MRC1	1513..>1593	CDD:286523	15/85 (18%)
		ERCC4	1846..1953	CDD:280828
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1948
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900