DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mus81 and Ercc4

DIOPT Version :9

Sequence 1:	NP_569873.1	Gene:	mus81 / 31044	FlyBaseID:	FBgn0040347	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_056584.2	Gene:	Ercc4 / 50505	MGIID:	1354163	Length:	917	Species:	Mus musculus

Alignment Length:	438	Identity:	95/438 - (21%)
Similarity:	157/438 - (35%)	Gaps:	119/438 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLREP----NPLF----TRWLERWLREAERREQKSQFSLRQALESLKSYPLPLASGRDCSILRG- 63
            :|:||    :||.    ...|.|.|.|.|.|             .:..|...|...|...|.|.
Mouse   547 ILKEPLTIIHPLLGCSDPYALTRVLHEVEPR-------------YVVLYDAELTFVRQLEIYRAS 598

  Fly    64 ------------FGGTLCQLIDEELRHHRGLQLLPQEAVVQERYEQQVQAVVRKVQEKQLEHQKR 116
                        :||:     .||.|:   |..|.:|   :|.:|:.::.....|..::.|
Mouse   599 RPGKPLRVYFLIYGGS-----TEEQRY---LTALRKE---KEAFEKLIREKASMVVPEERE---- 648

  Fly   117 QNKCDRPRKLTKKDLAELAALEERERVVRMKPGQ----FQLLLLVDTQETSGKNKRVLDQTRSYL 177
                  .|..|..|||..:|..:.....|...||    .|..::||.:|           .||.|
Mouse   649 ------GRDETNLDLARGSAALDAPTDTRKAGGQEQNGTQSSIVVDMRE-----------FRSEL 696

  Fly   178 ESL----GARHEVRRLTIGDFLWVAQDQEGNELVLPYIVERKRMDDLASSIRDGRFHEQKHRLQH 238
            .||    |...|...|.:||::          |.....||||.:.||..|:..||.:.|
Mouse   697 PSLIHRRGIDIEPVTLEVGDYI----------LTPELCVERKSVSDLIGSLHSGRLYSQ------ 745

  Fly   239 CGLQHIIY----LVEDYGDNEQLGL-PLDSLQQALTNAKVQTGVRVVRTANHYRSMSYL-AGMSR 297
            |......|    |:.::..::...| |..:..|.::::.|.:.:.::..  |:..:..| .....
Mouse   746 CLAMSRYYRRPVLLIEFDPSKPFSLAPRGAFFQEMSSSDVSSKLTLLTL--HFPRLRLLWCPSPH 808

  Fly   298 TLGQIFAGKKLHSVDRGAIDQSTCLLTHSDLGLLKFRALYED------------SAKNAQLTVRE 350
            ...::|...|   .::...|.:|.:...:|...|.....|..            :|||.:..:.:
Mouse   809 ATAELFEELK---QNKPQPDAATAMAITADSETLPESDRYNPGPQDFVLKMPGVNAKNCRSLMNQ 870

  Fly   351 VFVQQLLQLHSLSLERAMAIVERYPTPRWLLD----AYAECADQKQAR 394
              |:.:.:|.:|||||...|:......:.|.|    |||:...:.:.|
Mouse   871 --VKNIAELATLSLERLTTILGHSGNAKQLHDFLHTAYADLVSKGRVR 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mus81	NP_569873.1	NT_Pol-beta-like	16..>96	CDD:299849	20/96 (21%)
mus81	NP_569873.1	ERCC4	157..295	CDD:280828	33/147 (22%)
Ercc4	NP_056584.2	Helicase-like. /evidence=ECO:0000250	1..457
		rad1	97..908	CDD:273163	93/428 (22%)
		Leucine-zipper 1	233..254
		Leucine-zipper 2	270..298
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	454..524
		Nuclear localization signal. /evidence=ECO:0000255	487..492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	643..681		10/47 (21%)
		Nuclease. /evidence=ECO:0000250	659..814		38/183 (21%)
		ERCC4	687..817	CDD:280828	34/158 (22%)
		HhH2, dimerization with ERCC1. /evidence=ECO:0000250	838..906		15/69 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1948
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900